Navigation Links
Sluggish cell division may help explain genital defects
Date:6/1/2010

owth and the structural defects we were finding in genitalia."

The knowledge may help scientists understand why an increasing number of boys are being born with birth defects called hypospadias, which involve incomplete formation of the urethral tube, resulting in an abnormally placed urethral opening on the underside of the penis. About one in 250 children has a urethral tube defect, more than double the frequency of 30 years ago.

The cell cycle controls whether a cell continues to give rise to more cells or stop dividing and become specialized with a specific function to carry out. Humans begin life as a single fertilized egg cell that eventually gives rise to countless cells in an adult. As each cell divides it must proceed through a growth phase, replicate its DNA and divide again, or it can be instructed to stop dividing and perform a specific function.

When scientists deleted the Sonic hedgehog gene in specific tissues at different stages of external genital development, they discovered the cell cycle takes longer than it normally does -- about 14.4 hours instead of the usual 8.5 hours for these cells. As a result, fewer cells are produced and genital growth is reduced by about 75 percent. The shape of the genitals is also altered.

"In this case, embryos wind up with underdeveloped, malformed genitalia, and the reason is that it takes nearly twice as long to complete the cell cycle, limiting the number of cells available to build the structure. What is surprising is that the number of cells seems to underlie the shape," said Ashley Seifert, a postdoctoral associate in the department of biology in the College of Liberal Arts and Sciences and first author of the paper. "We did not just see a miniaturized version of the genitals, we observed patterning defects, from subtle changes to severe malformations."

Researchers had thought malformations might be explained because important shaping genes that sculpt the genita
'/>"/>

Contact: John Pastor
jdpastor@ufl.edu
352-273-5815
University of Florida
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. ARES Aerospace and Defense Division Receives AS9100 Certification
2. Artificial light at night disrupts cell division
3. Way to go: MBL scientists identify driving forces in human cell division
4. Sweet! -- sugar plays key role in cell division
5. BIO-key(R) Shareholders Overwhelmingly Approve Sale of Law Enforcement Division
6. BIO-key(R) Shareholders Overwhelmingly Approve Sale of Law Enforcement Division
7. AAAS Pacific division scientific conference to meet in San Francisco Aug. 14 - 19
8. Protein that triggers plant cell division revealed by researchers
9. Slicing chromosomes leads to new insights into cell division
10. Study may aid efforts to prevent uncontrolled cell division in cancer
11. Brain building: Study shows brain growth tied to cell division in mouse embryos
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/25/2014)... age girls reach puberty is influenced by ,imprinted genes,a subset ... the gene. This is the first evidence that imprinted ... details of this study were published today in the journal ... as menarche, is a marker for the timing of puberty ... menses varies between girls, is an inherited trait, and is ...
(Date:7/25/2014)... 25, 2014 Biometrics industry expands ... to digital technology for online & commerce payments while ... (NASDAQ: GOOG ), LifeLock Inc. (NYSE: ... ), Apple Inc. (NASDAQ: AAPL ) and ... NXTD) a biometric authentication company focused on the growing ...
(Date:7/24/2014)... , July 24, 2014 /PRNewswire-iReach/ -- The Geneva Healthcare ... cardiac devices, has cut emergency room wait times by ... Diego (UCSD) Medical Center, according to a recent study ... Emergency Departments are using the suite to access data ... or defibrillators. "Using Geneva,s technology platform we ...
Breaking Biology News(10 mins):Could age of first period influence development of diseases in older women? 2Consumer Needs for Identity Theft Security Grows with Popularity of Latest Smart Technology Products - Biometrically Secure Digital Wallet to Replace Credit Card Dependency 2Consumer Needs for Identity Theft Security Grows with Popularity of Latest Smart Technology Products - Biometrically Secure Digital Wallet to Replace Credit Card Dependency 3Consumer Needs for Identity Theft Security Grows with Popularity of Latest Smart Technology Products - Biometrically Secure Digital Wallet to Replace Credit Card Dependency 4Consumer Needs for Identity Theft Security Grows with Popularity of Latest Smart Technology Products - Biometrically Secure Digital Wallet to Replace Credit Card Dependency 5Consumer Needs for Identity Theft Security Grows with Popularity of Latest Smart Technology Products - Biometrically Secure Digital Wallet to Replace Credit Card Dependency 6UC San Diego Medical Center Cuts Average ER Wait Time by 92 Minutes using the Geneva Healthcare Suite 2UC San Diego Medical Center Cuts Average ER Wait Time by 92 Minutes using the Geneva Healthcare Suite 3
... statistics buried within patient records or detailed in newspaper ... patterns, allowing the discovery of trends that were previously ... use of interactive maps and graphs, combined with word ... events like the spread of Swine flu," said Frank ...
... This release is available in French . ... Faculty of Medicine and the CHUQ Research Center have proven ... for Duchenne muscular dystrophy. The team, led by Professor Jacques ... article published today in the online version of the scientific ...
... tested the utility of the short version of WHO-DAS II, ... with depression, "which in the case of primary care is ... In Spain, more than 10% of the population suffer ... first to screen an individual who feels depressed. For this ...
Cached Biology News:Visualization of geographic patterns may predict spread of disease 2Researchers prove the gene responsible for Duchenne muscular dystrophy can be repaired 2It takes only 5 minutes to assess disability in patients with depression 2
(Date:7/24/2014)... 2014 -- A novel combination of microscopy and data ... Oak Ridge National Laboratory an unprecedented look at the ... and electrochemical properties. , The research team led ... surface of a perovskite manganite, a complex material that ... to understand surface behavior could benefit researchers who are ...
(Date:7/24/2014)... Security forces worldwide rely on sophisticated equipment, trained ... other public areas against terrorist attacks. A revolutionary ... about to make their job much easier. , ... Patolsky of Tel Aviv University ,s School of ... developed by the Herzliya company Tracense, picks up ...
(Date:7/24/2014)... Research and Markets has announced the addition ... report to their offering.  http://photos.prnewswire.com/prnh/20130307/600769 ... vitro growth of plant or animal cells for several ... Cell culture is a crucial step in tissue engineering ... consumables are necessary for the in vitro production of ...
(Date:7/24/2014)... 2014 Three companies from the angelMD ... Big C Competition. Out of 700 competition entrants, Chiron ... the semi-final round. In this round twenty teams are ... complete with mentoring from thought-leaders and medical entrepreneurs from ... the angelMD commitment to the Livestrong vision around the ...
Breaking Biology Technology:ORNL study reveals new characteristics of complex oxide surfaces 2Nano-sized chip 'sniffs out' explosives far better than trained dogs 2Global Cell Culture Market 2014-2018: Key Vendors are Becton, Dickinson and Co, EMD, GE Healthcare, Lonza Group, Sigma Aldrich and Thermo Fisher Scientific 23 angelMD Startups Make Livestrong Big C Semi-finals 2
... Consecutive Quarter of Profitability, OMAHA, Neb., Aug. 5 ... for the quarter,ended June 30, 2008. The Company reported ... second quarter 2008, compared to net income of $226,000,or ... The second quarter of 2008 represented the Company,s third ...
... ... - Net Loss Continued to Narrow - ... Updates 2008 Guidance - ... (Nasdaq: GHDX ) today reported financial results and business progress,for the quarter ended June 30, 2008., ...
... CogState Ltd. to Support Partnership, Comprehensive service ... global implementation of cognitive testing in clinical trials, ... -- United BioSource Corporation (UBC) and CogState Ltd. enter ... testing in,clinical trials., -- UBC has made a ...
Cached Biology Technology:Transgenomic Reports Second Quarter 2008 Results 2Transgenomic Reports Second Quarter 2008 Results 3Transgenomic Reports Second Quarter 2008 Results 4Transgenomic Reports Second Quarter 2008 Results 5Transgenomic Reports Second Quarter 2008 Results 6Transgenomic Reports Second Quarter 2008 Results 7Transgenomic Reports Second Quarter 2008 Results 8Transgenomic Reports Second Quarter 2008 Results 9Genomic Health Announces Second Quarter 2008 Financial Results and Business Progress 2Genomic Health Announces Second Quarter 2008 Financial Results and Business Progress 3Genomic Health Announces Second Quarter 2008 Financial Results and Business Progress 4Genomic Health Announces Second Quarter 2008 Financial Results and Business Progress 5Genomic Health Announces Second Quarter 2008 Financial Results and Business Progress 6Genomic Health Announces Second Quarter 2008 Financial Results and Business Progress 7Genomic Health Announces Second Quarter 2008 Financial Results and Business Progress 8Genomic Health Announces Second Quarter 2008 Financial Results and Business Progress 9Genomic Health Announces Second Quarter 2008 Financial Results and Business Progress 10United BioSource Corporation and CogState Ltd. Form Strategic Partnership to Support Cognitive Assessment in Clinical Research 2United BioSource Corporation and CogState Ltd. Form Strategic Partnership to Support Cognitive Assessment in Clinical Research 3United BioSource Corporation and CogState Ltd. Form Strategic Partnership to Support Cognitive Assessment in Clinical Research 4
... This kit is designed for the fast ... vector plasmids at any position (for the ... loxP-PGK-gb2-neo-loxP cassette is designed to allow neomycin ... cells. It combines a prokaryotic promoter (gb2) ...
... instrument to offer true walk-away automation of magnetic ... cells by either positive or negative selection, RoboSep ... at one time. RoboSep is easily controlled via ... interface makes it simple and fast to set ...
Plasmid expressing the LacZ reporter gene....
Plasmid expressing Zeocin resistance gene....
Biology Products: