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Slowing evolution to stop drug resistance
Date:11/16/2009

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"We stimulate the evolution of the yeast cell and observe it in real time. As our yeasts develop resistance to a particular drug, we measure how the survivability of the different strains changes during the process. Evolution progresses more slowly in some strains when a specific component is destroyed. These strains are like gold dust to us, because they tell us that these particular components are critical to the speed of evolution," says Jonas Warringer.

"This is how we eventually found the genes that regulate evolution. If, in the next phase, we can find a substance that can attack one of these components, we will be able to delay the development of drug resistance and ensure that today's drugs remain effective into the future."

The research project is funded by the Magnus Bergwall Foundation and other benefactors. Jonas Warringer hopes that evolution-slowing drugs will become available within the next 10-15 years.


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Contact: Jonas Warringer
jonas.warringer@cmb.gu.se
46-031-786-3961
University of Gothenburg
Source:Eurekalert  

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