Navigation Links
Slowing evolution to stop drug resistance
Date:11/16/2009

Infectious organisms that become resistant to antibiotics are a serious threat to human society. They are also a natural part of evolution. In a new project, researchers at the University of Gothenburg are attempting to find substances that can slow the pace of evolution, in order to ensure that the drugs of today remain effective into the future.

The resistance of infectious organisms to antibiotics is particularly serious in drugs against fungi. Fungal cells are similar to human cells, which means that it is difficult to develop effective drugs that can destroy them without also damaging human cells, i.e. without causing side effects. We must therefore safeguard the effectiveness of the few antifungal drugs that are available today. Resistance to these would leave many diseases without effective treatment.

A natural phenomenon

However, drug resistance is a natural part of evolution. Evolution creates random variations in the characteristics of organisms, which results in some of them developing greater tolerance to drugs to which they are exposed. This leads eventually to completely resistant fungal strains, and the drug will become totally ineffective. The quicker these random variations appear, the greater the risk of resistance developing. One way of combating drug resistance is to slow down the pace of evolution.

Slowing down evolution

Researcher Jonas Warringer at the Department of Cell and Molecular Biology is using advanced genetic experiments to try to find such "evolution-slowing" substances. In the first instance, this involves identifying the cell components that regulate the speed of evolution. Jonas Warringer and his colleagues are using ordinary brewer's yeast as a model for their studies. A yeast has 6 000 genes, and destroying single genes in otherwise identical organisms enables Jonas Warringer and his colleagues to use the method of exclusion.

Looking for gold dust

<
'/>"/>

Contact: Jonas Warringer
jonas.warringer@cmb.gu.se
46-031-786-3961
University of Gothenburg
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Landscape-scale treatment promising for slowing beetle spread
2. Researchers combat slowing yields with targeted fertilizer applications
3. Biologists, educators recognize excellence in evolution education
4. Study sheds light on evolution of human complexity
5. Evolution of hyperactivity is focus of free public lecture at UC Riverside
6. K-State receives more than $780,000 to fund graduate students studying ecology, evolution, genomics
7. Time in a bottle: Scientists watch evolution unfold
8. Science wins fight over evolution in schools, says Case Western Reserve University author
9. The amazing maze of maize evolution
10. Genetic conflict in fish led to evolution of new sex chromosomes
11. Frozen assets: NIAID researchers turn to unique resource for clues to norovirus evolution
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Slowing evolution to stop drug resistance
(Date:4/24/2014)... shows that cells are more resilient in taking care ... missing critical components, cells can adapt and make copies ... a study published in this week,s Cell Reports ... showed that cells can grow normally without a crucial ... information is stored in DNA, which has to be ...
(Date:4/24/2014)... America (ESA) is very pleased to announce that it ... Science from the University of Wisconsin. , The ... an international, open-access, peer-reviewed journal that publishes papers on ... arthropods -- from the molecular to the ecological -- ... is freely available to individuals and institutions, and it ...
(Date:4/24/2014)... could be improved with new insights into the make-up ... studying the Amazon Basin have revealed unprecedented detail of ... region by comparing satellite maps with hundreds of field ... assess more accurately the amount of carbon each tree ... offset schemes, in which trees are given a cash ...
Breaking Biology News(10 mins):Cell resiliency surprises scientists 2ESA to publish the Journal of Insect Science 2Amazon rainforest survey could improve carbon offset schemes 2
... September 19, 2011 Dr. Martin Fregene, Director of ... Center has been tasked with leading the implementation of ... the Honourable Minister for Agriculture and Natural Resources. ... remain a co-Principal Investigator of BC Plus sharing that ...
... to producing the developmental differences displayed by social insects ... organismal function, a new study has found. ... different ways by varying the genes they express, ultimately ... permits organisms to operate successfully in their environments. A ...
... Cystic fibrosis (CF), a chronic disease that clogs the ... by a genetic defect in a chloride channel called ... not fully understand how or why this defect occurs, ... Children (SickKids) in Toronto, Ontario, Canada has found a ...
Cached Biology News:Danforth Center scientist recruited to spearhead cassava green revolution for Nigeria 2Danforth Center scientist recruited to spearhead cassava green revolution for Nigeria 3Fast-evolving genes control developmental differences in social insects 2Fast-evolving genes control developmental differences in social insects 3Unraveling a new regulator of cystic fibrosis 2
(Date:1/14/2014)... and BETHESDA, Md. , ... joining together with two institutes from the National Institutes ... tools for bringing safer, more effective treatments to patients ... National Center for Advancing Translational Sciences (NCATS) and the ...
(Date:1/14/2014)...  RXi Pharmaceuticals Corporation (OTCQX: RXII), a biotechnology company ... addressing major unmet medical needs using RNA-targeted technologies, ... Allowance from the United States Patent and Trademark ... for the treatment of fibrosis. The patent covers ...
(Date:1/14/2014)... Bellingham, Washington, USA, and Cardiff, UK (PRWEB) January 13, ... and photonics technology development leader with more than 20 ... international society for optics and photonics . Hainsey will ... “We are delighted to have Dr. Hainsey join SPIE ...
(Date:1/14/2014)... 2014 Independent publisher Bitingduck Press, with ... Canada, has big ideas for 2014 in production and ... are to produce high-quality, low-cost, DRM-free ebooks and to ... , The first major development will be bookstore ...
Breaking Biology Technology:Organovo Announces Collaboration with National Institutes of Health 2Organovo Announces Collaboration with National Institutes of Health 3RXi Pharmaceuticals Receives US Notice of Allowance for a Key Patent Relating to its Self-Delivering Technology with sd-rxRNAs targeting CTGF, including RXI-109, for the Treatment of Fibrotic Disorders 2RXi Pharmaceuticals Receives US Notice of Allowance for a Key Patent Relating to its Self-Delivering Technology with sd-rxRNAs targeting CTGF, including RXI-109, for the Treatment of Fibrotic Disorders 3Photonics R&D Leader Bob Hainsey Joins SPIE Technical Staff 2Bitingduck Press Looks Forward to 2014 With Multimedia E-books 2
... July 9 ATS Medical, Inc.,(Nasdaq: ATSI ... and services, today announced it has obtained new ... of the ATS Open,Pivot(R) Mechanical Heart Valve., ... Open Pivot valve was implanted in Lausanne, Switzerland,on ...
... Wash., July 9 CellCyte Genetics,Corporation (CellCyte) (OTC ... to provide strategic investment and financial advice and,services. ... its two,core platform technologies and will work with ... development and commercialization of,CellCyte,s cell expander and stem ...
... -- WuXi PharmaTech (NYSE:,WX), a leading pharmaceutical, biotechnology ... operations in China and the United,States, today proudly ... General Manager of WuXi AppTec,s Atlanta Operations, one ... Inc., has been invited,to join the Association for ...
Cached Biology Technology:ATS Medical Confirms Excellent Durability of the ATS Open Pivot Mechanical Heart Valve 2CellCyte Genetics Retains InCap Group to Advise on Business Strategy and Financing 2CellCyte Genetics Retains InCap Group to Advise on Business Strategy and Financing 3CellCyte Genetics Retains InCap Group to Advise on Business Strategy and Financing 4WuXi AppTec VP and GM Invited to Join the AAMI Standards Board 2WuXi AppTec VP and GM Invited to Join the AAMI Standards Board 3
... kit is for fine-tuning the bombardment conditions ... is recommended when you are first using ... includes 0.25 g each of 0.6 micrometer, ... microcarriers, 100 each of 9 rupture disks, ...
... Arrays can be used to test the ... and sera that are commonly used as ... contains spots for 21 different protein preparations ... antibody crossreactivity and species specificity, QC of ...
... Sciences can provide custom microplate coating using advanced automated high ... of plate formats. We can also accommodate virtually any lot ... 0.5-320 L):, , 8 ... well microplate, 384 well microplate, ...
...
Biology Products: