Navigation Links
Sloppy shipping of human retina leads IU researchers to discover new treatment path for eye disease
Date:5/4/2012

invasion agreeing with that seen in young adults.

By combining thousands of simulations, Shirinifard was able to produce maps that related defects in each type of adhesion to the risk of each type of invasion. In turn, he could show that cell adhesion is key to keeping blood vessels out of the retina and that combination defects in the different types of adhesion are sufficient to determine the probability, pattern and rate of progression of CNV.

The full results of one of the most complex tissue evolution models ever deployed were published today in PLoS Computational Biology, and while the team has yet to move toward developing new CNV therapies, the work should have great significance in the search for better therapies, according to Biocomplexity Institute Director James Alexander Glazier, a co-author on the paper and professor in the IU Bloomington College of Arts and Sciences' Department of Physics.

"Hundreds of millions of dollars are spent annually to develop drugs and treatment approaches based on the two commonly hypothesized CNV initiation and progression mechanisms," he said. "Because the current work shows that neither hypothesized mechanism is an important cause of CNV, that money and effort are extremely unlikely to improve outcomes for patients. Scientists have been barking up the wrong tree. Instead, a search for therapies which restore normal adhesion in the eye is much more likely to produce effective treatments. In addition, the detailed agreement between simulation and clinical observations suggests that new approaches to measuring adhesion in patients would allow much more accurate predictions of the prognosis for individual patients."

The researchers believe these results will also have a much broader impact, as they apply to any tissue -- like the gut and the lung -- in which a basement membrane separates a capillary network from a nearby epithelium.

"The relationships between specific class
'/>"/>

Contact: Steve Chaplin
stjchap@iu.edu
812-856-1896
Indiana University
Source:Eurekalert  

Page: 1 2 3 4

Related biology news :

1. ESA map reveals European shipping routes like never before
2. Shipping industry sends help as project in Panama tackles amphibian crisis
3. UKs shipping emissions 6 times higher than expected, says new report
4. Reducing emissions from shipping: Commissions Joint Research Centre sets out some options
5. MBARI and Monterey Bay National Marine Sanctuary to study effects of shipping containers lost at sea
6. Increase in Arctic shipping poses risk to marine mammals
7. Swiss Institute of Bioinformatics celebrates 10th birthday by presenting major gifts to human health
8. Scientists identify novel inhibitor of human microRNA
9. During exercise, the human brain shifts into high gear on alternative energy
10. Complete Genomics launches, becomes worlds first large-scale human genome sequencing company
11. Research shows Brazilian acai berry antioxidants absorbed by human body
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Sloppy shipping of human retina leads IU researchers to discover new treatment path for eye disease
(Date:7/30/2014)... journal Scientific Reports , published by Nature ... that while global temperature is indeed increasing, so too ... each year,s average hottest and coldest temperatures will likely ... a wider range of potential high and low temperate ... even as overall temperatures rise, we may still continue ...
(Date:7/29/2014)... methods and applications for imaging and manipulation of the ... were the inspiration behind Neurophotonics , a new ... optics and photonics. , The first issue coincides with ... States, and a special section features articles that lay ... impact that optics and photonics will have on advancing ...
(Date:7/29/2014)... In the high-tech world of science, researchers sometimes ... Barbara,s Douglas McCauley did just that to study ... muricatum ) on coral reef ecosystems at two ... Using direct observation, animal tracking and computer simulation, ... Ecology, Evolution and Marine Biology, and his colleagues ...
Breaking Biology News(10 mins):Big data confirms climate extremes are here to stay 2SPIE launches Neurophotonics journal with special section on BRAIN Initiative 2SPIE launches Neurophotonics journal with special section on BRAIN Initiative 3Underwater elephants 2Underwater elephants 3
... 2013)In a series of papers to be presented next ... mechanism operating in the roots of a tropical grass ... greenhouse gas emissions. Referred to as "biological nitrification ... of nitrogen applied to soil as fertilizer into nitrous ...
... This news release is available in German ... daughter; like father, like son. Evolutionary biologists at the universities in ... also applies to inheriting a long life at least for ... descendants of these insects mostly inherit their lifespan from their own ...
... disease indicate future joint problems? Although researchers and clinicians ... chronic inflammatory diseases - periodontal disease and rheumatoid arthritis ... In an article published today in PLOS Pathogens ... and Systemic Diseases group researcher Jan Potempa, PhD, DSc, ...
Cached Biology News:'Grassroots action' in livestock feeding to help curb global climate change 2'Grassroots action' in livestock feeding to help curb global climate change 3'Grassroots action' in livestock feeding to help curb global climate change 4Inheritance of lifespan is sex-dependent in fruit flies 2Bacteria responsible for gum disease facilitates rheumatoid arthritis 2
(Date:7/30/2014)... Fla. , July 30, 2014  Dyadic ... biotechnology company whose patented and proprietary technologies are ... and other proteins for the bioenergy, bio-based chemical, ... appointment of Thomas "Tom" Dubinski as Vice President ... for leading the financial and information technology operations ...
(Date:7/30/2014)... 30, 2014 NCERC at Southern ... present his findings on corn stover pretreatment methods ... week in Washington, D.C. , “Arun’s selection ... is a testament to the success of our ... “Thanks to the foresight and vision of SIUE ...
(Date:7/30/2014)... LayerBio, Inc., an MIT spinoff developing novel drug ... seed financing from friends and family investors. Proceeds from ... novel sustained-release product for ophthalmology. , "We are grateful ... to this important work," said Dr. Ken Mandell, Founder ... areas in which innovations in drug delivery have already ...
(Date:7/29/2014)... --  Sequenom, Inc. (NASDAQ: SQNM ), ... solutions, and Mayo Medical Laboratories (MML), the ... the United States , have announced a license ... "We have great appreciation for Mayo Clinic,s commitment ... the opportunity to partner with the organization,s leading clinical ...
Breaking Biology Technology:Thomas Dubinski joins Dyadic as Chief Financial Officer 2Thomas Dubinski joins Dyadic as Chief Financial Officer 3Thomas Dubinski joins Dyadic as Chief Financial Officer 4NCERC at SIUE Researcher Takes Stage at Department of Energy Conference 2NCERC at SIUE Researcher Takes Stage at Department of Energy Conference 3Sequenom Enters Into License Agreement With Mayo Medical Laboratories 2Sequenom Enters Into License Agreement With Mayo Medical Laboratories 3Sequenom Enters Into License Agreement With Mayo Medical Laboratories 4
... Neurobiological,Technologies, Inc. (NTI(R)) (Nasdaq: NTII ... million from Merz Pharmaceuticals GmbH (Merz) for ... Memantine for the treatment of,moderate-to-severe Alzheimer,s disease ... an exclusive marketing agreement, NTI currently receives,quarterly ...
... CITY, April 30 /PRNewswire-FirstCall/ - AEterna Zentaris Inc.,(NASDAQ: ... company focused on,endocrine therapy and oncology, today announced ... CEO of Andros Men,s Health Institutes,in The Netherlands, ... a Poster,Session at the 23rd Annual European Association ...
... ... First Non-GAAP Profit; Sales Guidance Revised Upward, ... Neurology and Cancer, First Quarter 2008 Financial Highlights:, - Soliris(R) (eculizumab) net product sales were ... Q4 2007., - Q1 GAAP net loss was $4.2 million, or $0.11 net loss per share, ...
Cached Biology Technology:AEterna Zentaris: Lead Investigator for Cetrorelix Trials in BPH Wins Best Poster Presentation Award at European Association of Urology Meeting in Milan 2AEterna Zentaris: Lead Investigator for Cetrorelix Trials in BPH Wins Best Poster Presentation Award at European Association of Urology Meeting in Milan 3AEterna Zentaris: Lead Investigator for Cetrorelix Trials in BPH Wins Best Poster Presentation Award at European Association of Urology Meeting in Milan 4AEterna Zentaris: Lead Investigator for Cetrorelix Trials in BPH Wins Best Poster Presentation Award at European Association of Urology Meeting in Milan 5AEterna Zentaris: Lead Investigator for Cetrorelix Trials in BPH Wins Best Poster Presentation Award at European Association of Urology Meeting in Milan 6Alexion Reports First Quarter 2008 Results 2Alexion Reports First Quarter 2008 Results 3Alexion Reports First Quarter 2008 Results 4Alexion Reports First Quarter 2008 Results 5Alexion Reports First Quarter 2008 Results 6Alexion Reports First Quarter 2008 Results 7Alexion Reports First Quarter 2008 Results 8Alexion Reports First Quarter 2008 Results 9Alexion Reports First Quarter 2008 Results 10Alexion Reports First Quarter 2008 Results 11Alexion Reports First Quarter 2008 Results 12
Anti-Chicken IgY, (IgG) F(ab')2 Fragment Specific....
Presenilin 2 Immunogen: Synthetic peptide corresponding to residues 31-47 of human Presenilin 2. Storage: -20 C, Avoid Freeze/Thaw Cycles...
SHP-2 Antibody...
200 μg per ml DNA in 10 SSPE, 2 Denhardt's...
Biology Products: