Navigation Links
Sloppy shipping of human retina leads IU researchers to discover new treatment path for eye disease
Date:5/4/2012

maintaining the retina's structure.

Using an open-source modeling software program called CompuCell3D developed by the Biocomplexity Institute in collaboration with the University of Washington and the University of Wisconsin under National Institutes of Health funding, the team quickly began extending existing simulations to study the effects of adhesion defects.

"The simulations showed that reduced adhesion in the retina could indeed lead to its invasion by blood vessels," Shirinifard said. "But the complex structure of the retina meant that many types of adhesion could be important -- the three most prominent being between the pigmented retinal cells (the black lining of the eye) and Bruch's membrane (the substrate that supports the retina), between adjacent pigmented retinal cells, and between pigmented retinal cells and the overlying photoreceptors."

Those variables, the team realized, could be independent of one another or interact in complex ways, and knowing that the rate and type of progression of the disease varies greatly from patient to patient, they needed to examine many examples of each adhesion combination.

That's when Quarry, the IU computer cluster operated by the Office of the Vice President for Information Technology, was called in to push out 32,000 hours of calculations.

"We were able to model the interactions of different degrees of impairment of each type of adhesion and the variation from case to case," Shirinifard said. "Amazingly, these simulations were able to replicate the complex spectrum of CNV seen in the clinic."

Simulations of adhesion defects caused by reduced adhesion between pigmented retinal cells and Bruch's membrane -- the type of CNV typical of aging -- produced a pattern and frequency of invasion agreeing with that in the clinic. Similarly, reduced adhesion between neighboring pigmented retinal cells, typical of inflammation due to severe infection, produced a pattern of
'/>"/>

Contact: Steve Chaplin
stjchap@iu.edu
812-856-1896
Indiana University
Source:Eurekalert  

Page: 1 2 3 4

Related biology news :

1. ESA map reveals European shipping routes like never before
2. Shipping industry sends help as project in Panama tackles amphibian crisis
3. UKs shipping emissions 6 times higher than expected, says new report
4. Reducing emissions from shipping: Commissions Joint Research Centre sets out some options
5. MBARI and Monterey Bay National Marine Sanctuary to study effects of shipping containers lost at sea
6. Increase in Arctic shipping poses risk to marine mammals
7. Swiss Institute of Bioinformatics celebrates 10th birthday by presenting major gifts to human health
8. Scientists identify novel inhibitor of human microRNA
9. During exercise, the human brain shifts into high gear on alternative energy
10. Complete Genomics launches, becomes worlds first large-scale human genome sequencing company
11. Research shows Brazilian acai berry antioxidants absorbed by human body
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Sloppy shipping of human retina leads IU researchers to discover new treatment path for eye disease
(Date:7/31/2014)... University researcher found that bacteria in the Gulf of ... oil released during the Deepwater Horizon spill in the ... contaminants. , In two new studies conducted in a ... species of bacteria called Colwellia likely consumed ... compounds that were released as part of the oil ...
(Date:7/31/2014)... that marine noise can affect animal movement and communication, ... Bristol and Exeter and the cole Pratique des Hautes ... noise stops embryonic development and increases larval mortality in ... Stylocheilus striatus used in this study) usually ... feed on toxic alga but this study, conducted in ...
(Date:7/30/2014)... in Lewis Carroll,s Through the Looking Glass, collaborators ... of Singapore improved a 35-year-old ecology model to ... millions of years. , The new model, called ... "Red Queen Effect," an evolutionary hypothesis introduced by ... that organisms must constantly increase their fitness (or ...
Breaking Biology News(10 mins):Boat noise impacts development and survival of sea hares 2Classic Lewis Carroll character inspires new ecological model 2Classic Lewis Carroll character inspires new ecological model 3
... produced by the body. It cannot regenerate itself, because it ... by the time the tooth appears in the mouth. The ... damage, and decay. For this reason, it is exciting to ... teeth, using culturing and transplantation techniques. In the emergent field ...
... cancers, researchers from Whitehead Institute and Massachusetts Institute of Technology ... MicroRNAs are tiny snippets of RNA that can repress activity ... copies DNA information and starts the process of protein production). ... in worms. It took seven years for the second one ...
... promising alternative for the reconstitution of lost ... complications associated with traditional transplants. Tissue engineers ... by using engineered tissue substitutes that can ... into the host tissue. The traditional tissue-engineering ...
Cached Biology News:Scientists re-grow dental enamel from cultured cells 2MicroRNA helps prevent tumors 2MicroRNA helps prevent tumors 3
(Date:7/30/2014)... 30, 2014 Selexis SA , ... drug discovery and mammalian cell line development, announced today ... ™ will be presented at the 10th Annual ... September 8 – 10, 2014 at the Double Tree ... The following abstract will be presented during an oral ...
(Date:7/30/2014)... July 30, 2014   Wyle has ... Integrated Lifecycle Mission Support Services (FILMSS) contract awarded ... Under the terms of the contract, Wyle will ... Moffett Field, Calif. In particular, Wyle will provide ... development projects on the International Space Station and ...
(Date:7/30/2014)... July 30, 2014. Applied DNA Sciences, ... provides DNA-based authentication and security solutions and services, has ... Life Sciences, a newly created position, with a starting ... lead APDN’s drive to build its business in pharmaceuticals ... customers, provide guidance to APDN’s R&D efforts, and apply ...
(Date:7/30/2014)... Vycom announces the addition of Thermax ... meet Factory Mutual (FM) 4910 fire propagation and smoke ... benches, process tools, fume hoods, furniture and cabinetry. These ... semiconductor wafers used in electronic chip manufacturing. , ... with excellent workability and superior aesthetics. It is available ...
Breaking Biology Technology:Selexis SA to Present New Data and a Case Study at IBC’s Cell Line Development and Engineering Conference 2Selexis SA to Present New Data and a Case Study at IBC’s Cell Line Development and Engineering Conference 3Wyle Wins NASA's Fully Integrated Lifecycle Mission Support Services Contract 2Dr. Michael E. Hogan, Ph.D., Joins Applied DNA Sciences as Vice President, Life Sciences 2Dr. Michael E. Hogan, Ph.D., Joins Applied DNA Sciences as Vice President, Life Sciences 3Vycom Announces Flametec® Thermax PVC (FM4910 Listed) For a Variety of Clean Room Applications with Excellent Workability and Aesthetics 2
... /PRNewswire-FirstCall/ - OncoGenex,Pharmaceuticals (NASDAQ: OGXI ) announced ... Fast Track designation from the U.S. Food & ... prostate cancer. OGX-011 is currently completing five Phase ... and is designed to,inhibit the production of a ...
... 21 /PRNewswire-FirstCall/ - Resverlogix Corp.,("Resverlogix") (TSX:RVX) is pleased ... on August 25, 2008 at 11:00 am MDT ... the presentation there will be a live,question and ... at the following link:, http://services.choruscall.com/links/resverlogix080825.html , ...
... BPUR ) today announced its financial results for the ... the company reported a net,loss of $4.6 million, or ... $6.4 million, or $0.41 per common share, for the ... July 31, 2008 and 2007 were,37,340,051 and 15,592,025, respectively., ...
Cached Biology Technology:FDA Grants Fast Track Designation for OncoGenex Pharmaceuticals' Lead Product Candidate OGX-011 2FDA Grants Fast Track Designation for OncoGenex Pharmaceuticals' Lead Product Candidate OGX-011 3FDA Grants Fast Track Designation for OncoGenex Pharmaceuticals' Lead Product Candidate OGX-011 4Resverlogix Notice of Conference Call & Webcast 2Biopure Announces 2008 Third Quarter Financial Results 2Biopure Announces 2008 Third Quarter Financial Results 3Biopure Announces 2008 Third Quarter Financial Results 4Biopure Announces 2008 Third Quarter Financial Results 5Biopure Announces 2008 Third Quarter Financial Results 6Biopure Announces 2008 Third Quarter Financial Results 7
...
... PlusOne Silver Staining Kit, Protein, 1. ... and Dernick (1), the kit gives ... electrophoresis systems.Silver Staining Kit, Protein provides ... proteins in polyacrylamide gels in less ...
Mouse monoclonal [IFR0104] to Salmonella enteriditis ( Abpromise for all tested applications)....
Cyno macaque plasma and serum - various quantities available...
Biology Products: