Navigation Links
Slight changes in 2 key genes appear to launch breast cancer development
Date:5/12/2010

Washington, DC Researchers at Georgetown Lombard Comprehensive Cancer Center have been able to show, in mice, how just a little adjustment in the expression of two common genes can promote the kind of cellular changes that led to breast cancer. They say these tweaks likely mimic natural variation women have in expression of the two genes.

In the May 15 issue of Cancer Research published online today, the scientists say that a readout of these two genes estrogen receptor alpha and p53 in healthy women could provide an "interacting biomarker" that might predict future breast cancer risk.

"It was believed that both of these genes only act once breast cancer had developed p53 mutations are found in many cancers, including breast cancer, and the majority of women with breast cancer have over-expression of this common estrogen receptor," says the study's lead investigator, Priscilla A. Furth, MD, a professor of oncology and medicine with Lombardi at Georgetown University Medical Center. "What wasn't known is that different levels of expression of these genes can help launch the cellular changes that lead to breast cancer.

"That suggests that testing women for their own variations in these genes might potentially give us a clue as to which women are at higher risk for development of breast cancer," Furth says.

The first author of the study is Edgar S. Daz-Cruz, Ph.D., a fellow at Lombardi supported by a Susan G. Komen for the Cure Postdoctoral Fellowship.

One focus of Furth's lab is to eventually develop a panel of tests that will accurately determine an individual woman's future risk of developing breast cancer so that counseling and monitoring can be tailored to each patient. To find the genes and proteins that carry such risk, she has developed unique mouse models in which she can manipulate various genetic factors to see how breast cancer risk changes over time.

In this study, Daz-Cruz and F
'/>"/>

Contact: Karen Mallet
km463@georgetown.edu
215-514-9751
Georgetown University Medical Center
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Study finds women slightly more likely to die than men in the 30 days following a heart attack
2. Home tooth bleaching slightly reduces enamel strength
3. Slight changes in climate may trigger abrupt ecosystem responses
4. Chesapeake Bay ecosystem health remains poor, but slightly improved in 2007
5. Subtle changes in PTEN tumor suppressor gene can determine cancer susceptibility
6. Lifestyle changes for teens critical in light of research about teens heart disease risk
7. Multiple sclerosis risk changes with the season
8. Small changes in protein chemistry play large role in Huntingtons disease
9. Nanoscale changes in collagen are a tipoff to bone health
10. Genomes of identical twins reveal epigenetic changes that may play role in lupus
11. Lifestyle changes may stave off diabetes for a decade
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/30/2014)... and strawberries all have in common? Unlike most ... and are diploid, these organisms are all polyploid, meaning ... and salmon have 3 and 4 sets of chromosomes, ... seem surprising, in fact most plant species are polyploid. ... century ago, but only recently, with the development of ...
(Date:9/30/2014)... Salk professor and Howard Hughes Medical Institute investigator, ... named recipients in the 2014 round of grants ... the BRAIN (Brain Research through Advancing Innovative Neurotechnologies) ... announced September 30, provides more than $3 million ... years. , The BRAIN Initiative, launched last year, ...
(Date:9/30/2014)... of Medicine reports positive results of a phase ... subset of lung cancer marked by rearrangement of the ... with advanced non-small cell lung cancer testing positive for ... with 3 complete responses and 33 partial responses. Median ... disease to resume its growth after being slowed by ...
Breaking Biology News(10 mins):Gene doubling shapes the world: Instant speciation, biodiversity, and the root of our existence 2Gene doubling shapes the world: Instant speciation, biodiversity, and the root of our existence 3Gene doubling shapes the world: Instant speciation, biodiversity, and the root of our existence 4Salk scientists receive $3 million for BRAIN Initiative grant 2NEJM: Crizotinib effective in Phase 1 trial against ROS1 lung cancer 2
... On a popular children's game participants stand as close ... coaxing cells to be very, very close without actually ... challenges for cell biologists. , Now MIT researchers led ... computer science at the Harvard-MIT Division of Health Sciences ...
... Researchers at Mount Sinai School of Medicine have just ... of the microdomains of leukocytes or white blood cells. ... cells in which receptors and signaling molecules accumulate during ... to view white blood cell subsets and their forming ...
... sugars, a technique developed by University of Michigan analytical ... diagnosis and treatment options. , A growing body of ... to proteins on cancer cell surfaces as accomplices in ... keen to characterize these glycans, but traditional analytical methods ...
Cached Biology News:MIT device draws cells close -- but not too close -- together 2MIT device draws cells close -- but not too close -- together 3New imaging technique tracks traffic patterns of white blood cells 2A sweet step toward new cancer therapies 2
(Date:10/1/2014)... The participants committed to not only creating unique business ... adjusting, tweaking and testing virtual models and 3D test ... , “I enjoyed being involved as a judge,” stated ... showed a commendable range exploring the technical capabilities of ... and the creativity of the contestants.” , Array Architects ...
(Date:10/1/2014)... VA (PRWEB) October 01, 2014 ... Diagnostic, Clinical Therapeutics, Healthcare IT, and Laboratory Testing industries, ... regulatory positions at the director level and above from ... struggling to stay on top of rapid breakthroughs in ... result, many diagnostic companies have been forced to fold, ...
(Date:9/30/2014)... release is available in German . ... around several quantum dots in a semiconductor layer. Quantum dots ... of atomic processes. If a short laser pulse is fired ... the quantum dot experiences a change in the electromagnetic field ... the emission of light by the dot. As soon as ...
(Date:9/30/2014)... Report Details Biosimilar drugs – ... Do you want to find sales potentials of ... for those biological drugs from 2014, helping you ... data, R&D trends, opportunities and selling prospects. In ... 2024 at overall world market, therapeutic class, molecule ...
Breaking Biology Technology:Array Architects Challenges Staff to Create with 3D Printer 2Slone Partners Meets Growing Demand as Industry Focuses on Reimbursement & Regulation 2Ultrafast remote switching of light emission 2Biosimilars and Follow-On Biologics: World Industry and Market Prospects 2014-2024 2Biosimilars and Follow-On Biologics: World Industry and Market Prospects 2014-2024 3Biosimilars and Follow-On Biologics: World Industry and Market Prospects 2014-2024 4Biosimilars and Follow-On Biologics: World Industry and Market Prospects 2014-2024 5
... TetraLogic Pharmaceuticals , a biopharmaceutical company developing ... today announced the initiation of a Phase 1/2 clinical ... in elderly patients with acute myelogenous leukemia (AML). The ... the University of Pennsylvania and is an open-label, non-randomized ...
... Technologies, Inc. (NYSE AMEX: SNT ) announced ... for on-demand viewing. LINK:    www.retailinvestorconferences.com ... button. Senesco Technologies, presentation will be available ... from the "virtual trade booth" for the next three ...
... (OTC.BB: NWBO) (Northwest Bio) announced today that it has ... $31.5 million of liabilities through settlement, retirement and conversion. ... This restructuring reduces the Company,s liabilities from ... to $16.5 million. Only about $2.3 million of this ...
Cached Biology Technology:TetraLogic Pharmaceuticals Announces Initiation of a Phase 1/2 Clinical Trial of TL32711 in Patients with Acute Myelogenous Leukemia (AML) 2TetraLogic Pharmaceuticals Announces Initiation of a Phase 1/2 Clinical Trial of TL32711 in Patients with Acute Myelogenous Leukemia (AML) 3Senesco Technologies, Inc. Investor Presentation Now Available for On-demand Viewing at RetailInvestorConferences.com 2Northwest Bio Implements Major Balance Sheet Clean-Up 2Northwest Bio Implements Major Balance Sheet Clean-Up 3Northwest Bio Implements Major Balance Sheet Clean-Up 4Northwest Bio Implements Major Balance Sheet Clean-Up 5
GeneRacer is an advanced RACE (rapid amplification of cDNA ends) technique that improves the efficiency of amplifying full-length 5' and 3' cDNA ends. With the GeneRacer Kit you can:...
Mouse Wnt-9b Affinity Purified Polyclonal Ab Keywords: Wnt 9b Protein Family: Cancer Stem Cell Markers, Wnt Ligands...
One-step, microplate or cuvet, colorimetric, linear detection range 0.6 mM to 100 mM. Procedure: 2 min....
One-step, microplate or cuvet, colorimetric, linear detection range 6 mg/dL to 100mg/dL. Procedure: 15 min....
Biology Products: