Navigation Links
Slight changes in 2 key genes appear to launch breast cancer development
Date:5/12/2010

Washington, DC Researchers at Georgetown Lombard Comprehensive Cancer Center have been able to show, in mice, how just a little adjustment in the expression of two common genes can promote the kind of cellular changes that led to breast cancer. They say these tweaks likely mimic natural variation women have in expression of the two genes.

In the May 15 issue of Cancer Research published online today, the scientists say that a readout of these two genes estrogen receptor alpha and p53 in healthy women could provide an "interacting biomarker" that might predict future breast cancer risk.

"It was believed that both of these genes only act once breast cancer had developed p53 mutations are found in many cancers, including breast cancer, and the majority of women with breast cancer have over-expression of this common estrogen receptor," says the study's lead investigator, Priscilla A. Furth, MD, a professor of oncology and medicine with Lombardi at Georgetown University Medical Center. "What wasn't known is that different levels of expression of these genes can help launch the cellular changes that lead to breast cancer.

"That suggests that testing women for their own variations in these genes might potentially give us a clue as to which women are at higher risk for development of breast cancer," Furth says.

The first author of the study is Edgar S. Daz-Cruz, Ph.D., a fellow at Lombardi supported by a Susan G. Komen for the Cure Postdoctoral Fellowship.

One focus of Furth's lab is to eventually develop a panel of tests that will accurately determine an individual woman's future risk of developing breast cancer so that counseling and monitoring can be tailored to each patient. To find the genes and proteins that carry such risk, she has developed unique mouse models in which she can manipulate various genetic factors to see how breast cancer risk changes over time.

In this study, Daz-Cruz and F
'/>"/>

Contact: Karen Mallet
km463@georgetown.edu
215-514-9751
Georgetown University Medical Center
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Study finds women slightly more likely to die than men in the 30 days following a heart attack
2. Home tooth bleaching slightly reduces enamel strength
3. Slight changes in climate may trigger abrupt ecosystem responses
4. Chesapeake Bay ecosystem health remains poor, but slightly improved in 2007
5. Subtle changes in PTEN tumor suppressor gene can determine cancer susceptibility
6. Lifestyle changes for teens critical in light of research about teens heart disease risk
7. Multiple sclerosis risk changes with the season
8. Small changes in protein chemistry play large role in Huntingtons disease
9. Nanoscale changes in collagen are a tipoff to bone health
10. Genomes of identical twins reveal epigenetic changes that may play role in lupus
11. Lifestyle changes may stave off diabetes for a decade
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/29/2014)... household and industrial products are in the environment – ... of them, scientists have yet to determine whether they ... toward doing that by estimating which substances people are ... in the ACS journal Environmental Science & Technology ... the risks to human health of any given substance ...
(Date:10/29/2014)... Mich. – As bodies decompose, their types and ... clues they provide could mean the difference between ... Michigan State University is using a more than ... Detroit death-scene investigators examine these changing populations. The ... geographical location of death, gender, race, socioeconomic relations ...
(Date:10/29/2014)... new research potential of the Barcode of Life ... the Biodiversity Data Journal (BDJ) ... and imported these into a human-readable text developed in ... Data were used to study the species distributions of ... subfamily. , BOLD is originally designed to support the ...
Breaking Biology News(10 mins):MSU partners with Detroit to investigate death scenes 2Go straight and publish: From Barcode of Life Data Systems to scholarly publishing systems 2
... a type of contaminant in the atmosphere, considered very ... and visibility. Chemist Ms Ainhoa Inza studied the presence ... the Basque Country (CAV-EAE); concretely, the type known as ... micras in diameter. Amongst other things, the researcher compared ...
... Rochester Institute of Technology has been awarded a ... Standards and Technology to assist in construction of ... university,s Golisano Institute for Sustainability. The building will ... transfer, education and outreach and provide a state-of-the-art ...
... University of Wellington, New Zealand, crouched low to the ground and ... plant cushion, then sat back waiting to see if something would ... have thought so, but Pufal was trying to find potential plant ... Although the ability to move is typically thought to ...
Cached Biology News:Thesis studies atmospheric PM contaminant in the Basque Autonomous Community 2RIT receives federal grant to construct new sustainability research facility 2RIT receives federal grant to construct new sustainability research facility 3RIT receives federal grant to construct new sustainability research facility 4Plants that move: How a New Zealand species disperses seeds in a high alpine, wet environment 2Plants that move: How a New Zealand species disperses seeds in a high alpine, wet environment 3
(Date:10/30/2014)... (PRWEB) October 30, 2014 Spartan Bioscience ... Spartan RX CYP2C19 System . It detects CYP2C19 genetic ... cheek swab. , The Spartan RX CYP2C19 System is ... has been approved in Canada. Due to the system’s ... may be used by healthcare professionals such as doctors, ...
(Date:10/30/2014)... Avure Technologies celebrates a year of success and the one-year ... of high volume High Pressure Processing (HPP) systems. , “We’re ... PackExpo this year, which is where we first announced the ... CEO at Avure. “Sales of the new Avure machine are ... challenges of market demand for higher throughput. We sold our ...
(Date:10/30/2014)... Calif. , Oct. 30, 2014 Isis Pharmaceuticals, ... therapeutics, today announced that management will present a company overview ... at 8:30 a.m. ET in Boston, MA. ... be available on the "Investors & Media" section of the ... on the Isis website within 48 hours and will be ...
(Date:10/30/2014)... , Oct. 30, 2014  Regado Biosciences, Inc. ... will hold a conference call and live audio webcast ... to discuss its third quarter 2014 financial results. ... call by dialing (888) 347-1165 for domestic callers or ... be webcast live under the investor relations section of ...
Breaking Biology Technology:Health Canada approves first near-patient DNA test for personalized medicine 2Health Canada approves first near-patient DNA test for personalized medicine 3In High Demand: New High Pressure Processing (HPP) System with Maximum Throughput Drives Strong Sales 2In High Demand: New High Pressure Processing (HPP) System with Maximum Throughput Drives Strong Sales 3Isis Pharmaceuticals to Present at the Nomura Biotechnology Conference 2Regado Biosciences to Provide Third Quarter 2014 Financial Results 2
... HOBOKEN, N.J. , Aug. 2 Octapharma USA ... Grants Program is the Rush Hemophilia & Thrombophilia Center at ... pre-clinical research focused on human protein therapies in hematology, immune therapy, intensive care ... ...
... CLEVELAND , Aug. 2 DATATRAK ... focused on global eClinical solutions for the clinical trials ... selected DATATRAK,s eClinical™ platform for a cardiovascular clinical study ... . Reaping the benefits of a unified platform, DAIICHI ...
... enough. Now imagine 15,000 of them. A Northwestern ... 15,000 identical skylines with tiny beams of light using ... Details of the new method, which could do for ... and information transfer, will be published Aug. 1 by ...
Cached Biology Technology:Octapharma Grants Program Awards First Research Grant to Rush University Medical Center 2Octapharma Grants Program Awards First Research Grant to Rush University Medical Center 3Octapharma Grants Program Awards First Research Grant to Rush University Medical Center 4Octapharma Grants Program Awards First Research Grant to Rush University Medical Center 5Octapharma Grants Program Awards First Research Grant to Rush University Medical Center 6DAIICHI SANKYO EUROPE GmbH Selects DATATRAK eClinical™ for Pan-European Systolic Hypertension Study 2DAIICHI SANKYO EUROPE GmbH Selects DATATRAK eClinical™ for Pan-European Systolic Hypertension Study 3DAIICHI SANKYO EUROPE GmbH Selects DATATRAK eClinical™ for Pan-European Systolic Hypertension Study 415,000 beams of light 215,000 beams of light 3
RABBIT ANTI AMPHOTERIN...
Amino Acid Analysis is performed using ion-exchange separation of the amino acids from acid hydrolysates, followed by ninhydrin detection. Typical quantities required are 0.1 to 0.5 mg, depending on...
... by R. Edwards (1996) • ... types of immunoassays, including RIA, ... and on the photoluminescent and ... information is also given on ...
... contains the basic components required for the ... and recombinant Feline IL-10 in cell culture ... materials to run ELISAs on approximately fifteen ... are met: The assay is run ...
Biology Products: