Navigation Links
Slicing proteins with Occam's Razor
Date:9/30/2010

ys.

Shaped a bit like a tennis racket over a basket, this tiny arm of the protein moves, through thermal fluctuations, to open or close the binding site near the myoglobin's iron-filled center. "As the atoms move in one direction it becomes easier to bind oxygen," says DeWitt, "and as they move in the reverse direction it becomes less easy."

And how this distal histidine moves should vary between the whale and the cheetah. "I would imagine," says Kelvin Chu, associate professor of physics and DeWitt's co-author, "that there has been evolutionary pressure on every species to adapt this motion in the myoglobin for their particular oxygen-binding needs."

"That's a testable hypothesis," Chu says. "What we would expect to see across species is that the tennis rackets are in different places or move different amounts."

DeWitt and Chu's work extends far beyond myoglobin. The two physicists see broad application of their new method in creating custom-crafted proteins.

"Once you know what these motions are and what the important atoms are," says Chu, "you can make mutants of proteins that have different binding attributes." And these different attributes have promise in developing new biotechnologies "ranging from blood substitutes to organic solar cells," he says.

Proteins are a cell's heavy laborers: hauling water, taking out the trash, carrying in the groceries -- and trillions of other tasks that make life. But how the shape of a protein determines its function remains one of the most vexing and important questions in the physics of biology.

Proteins are not the static, Lego-like objects you might see in an x-ray photograph in a biochemistry textbook. Instead, made from long chains of amino acids scrunched into various blobs and globs, a protein is always jumping between slightly different structural arrangements due to thermal motion of its atoms. Even a modest-sized protein like myoglobin has more possible
'/>"/>

Contact: Joshua Brown
joshua.e.brown@uvm.edu
802-656-3039
University of Vermont
Source:Eurekalert  

Page: 1 2 3 4

Related biology news :

1. Slicing chromosomes leads to new insights into cell division
2. Scripps Research scientists win $65 million in new grants to reveal form and function of proteins
3. RD114 envelope proteins provide an effective and versatile approach to pseudotype lentiviral vectors
4. UCLA receives $12.5M to lead international project to study proteins implicated in heart disease
5. NIH grants will advance studies of the form and function of proteins
6. Purifying proteins: Rensselaer researchers use NMR to improve drug development
7. Proteins to yield new clues in fight against osteoporosis
8. UT Health Science Center San Antonio lands $11.6 million to study cardiac proteins
9. Proteins linked with Alzheimers, other neurodegenerative diseases found to clump in normal aging
10. $22.5 million grant funds international study of membrane proteins
11. Nanoblasts from laser-activated nanoparticles move molecules, proteins and DNA into cells
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Slicing proteins with Occam's Razor
(Date:9/17/2014)... Spanish researchers have obtained the first partial genome sequence ... pig found at the site of the Montsoriu Castle ... pig is closely related to today,s Iberian pig. Researchers ... with modern Iberian pigs. , The study, published in ... of pig species, and particularly on that of the ...
(Date:9/17/2014)... 2014 Researchers at UTSouthwestern Medical Center have found ... apolipoprotein E, called apoE3, helps repair the lining of ... not get the benefit of this repair, putting them ... that we have identified one mechanism by which apoE3 ... variant, apoE4, is detrimental," said Dr. Philip Shaul ...
(Date:9/17/2014)... been growing significantly faster since the 1960s. The typical ... but they have accelerated -- by as much as ... carried out by scientists from Technische Universitt Mnchen based ... been continuously observed since 1870. Their findings were published ... ago, "forest dieback" was a hot topic, with the ...
Breaking Biology News(10 mins):Iberian pig genome remains unchanged after 5 centuries 2Protein variant may boost cardiovascular risk by hindering blood vessel repair 2Global change: Trees continue to grow at a faster rate 2Global change: Trees continue to grow at a faster rate 3
... one day help physicians detect the very earliest stages ... , It would do so by improving the quality ... diagnostic tools used in doctors' offices ?the ultrasound machine. ... nano-sized particles injected into the animals improved the resulting ...
... have been infected with the H5N1 avian influenza virus, mostly ... virus does not spread easily from its pioneering human hosts ... a study of cells in the human respiratory tract reveals ... that makes it difficult for the virus to jump from ...
... Allergy and Infectious Diseases (NIAID), part of the National ... of anthrax toxin that worked well in small-scale animal ... of anthrax antitoxin is an important advance, not only ... but also because this technique could be used to ...
Cached Biology News:Nanotechnology may find disease before it starts 2Nanotechnology may find disease before it starts 3Cell barrier shows why bird flu not so easily spread among humans 2Cell barrier shows why bird flu not so easily spread among humans 3Scientists design potent anthrax toxin inhibitor 2Scientists design potent anthrax toxin inhibitor 3
(Date:9/17/2014)... BioClinica®, Inc., a leading provider of outsourced ... of its experts are speaking at the 20th ... be held September 28 to October 1 in ... announced the innovative Compass technology, a risk-based ... acquired earlier this year, is up for the ...
(Date:9/17/2014)... Intarcia Therapeutics, Inc. today announced ... of the cost and predictability of non-adherence in type ... Meeting of the European Association for the Study of ... Frois , Ph.D., of Analysis Group, Inc. presented data ... retrospective studies to characterize the prevalence of non-adherence and ...
(Date:9/17/2014)... - SQI Diagnostics Inc. (TSX-V: SQD) (OTCQX: SQIDF), a ... and products for advanced microarray diagnostics, today announced that ... the United States on the ... September 17, 2014 on the OTCQX under the symbol ... TSX Venture Exchange under its existing symbol SQD. ...
(Date:9/17/2014)... FOREST, California , 17 de septiembre ... CYRX) ("la compañía"), principal proveedor mundial de ... de las ciencias de la vida, anunció ... compañía de logística global con sede en ... su base de clientes Europa en rápido ...
Breaking Biology Technology:BioClinica to Present at 20th Annual SCDM Conference 2BioClinica to Present at 20th Annual SCDM Conference 3Intarcia Reveals New Insights At EASD Meeting Characterizing The Burden Of Poor Control And Non-Adherence To Anti-Diabetic Therapies 2Intarcia Reveals New Insights At EASD Meeting Characterizing The Burden Of Poor Control And Non-Adherence To Anti-Diabetic Therapies 3Intarcia Reveals New Insights At EASD Meeting Characterizing The Burden Of Poor Control And Non-Adherence To Anti-Diabetic Therapies 4Intarcia Reveals New Insights At EASD Meeting Characterizing The Burden Of Poor Control And Non-Adherence To Anti-Diabetic Therapies 5SQI Diagnostics to begin Trading on the OTCQX Marketplace in the United States 2SQI Diagnostics to begin Trading on the OTCQX Marketplace in the United States 3Cryoport contrata a Broekman Group para mejorar su apoyo operativo y logístico en Europa 2Cryoport contrata a Broekman Group para mejorar su apoyo operativo y logístico en Europa 3Cryoport contrata a Broekman Group para mejorar su apoyo operativo y logístico en Europa 4Cryoport contrata a Broekman Group para mejorar su apoyo operativo y logístico en Europa 5
... Tiny chemical particles emitted by diesel exhaust fumes could raise ... have found that ultrafine particles produced when diesel burns are ... blood clots forming in arteries, leading to a heart attack ... measured the impact of diesel exhaust fumes on healthy volunteers ...
... interview with a researcher, please contact the Communications and External ... For more information on ORNL and its research and development ... you have a general media-related question or comment, you can ... Moving toward nanorobots . . . Nanoscale robots ...
... FALLS, Idaho,  July 13, 2011 International Isotopes ... nuclear medicine products, is pleased to announce it ... construction, technical, and management services firm, as the ... depleted uranium de-conversion facility in Lea County, New ...
Cached Biology Technology:Diesel fumes pose risk to heart as well as lungs, study shows 2Story tips from the Department of Energy's Oak Ridge National Laboratory, July 2011 2Story tips from the Department of Energy's Oak Ridge National Laboratory, July 2011 3Story tips from the Department of Energy's Oak Ridge National Laboratory, July 2011 4International Isotopes Inc. Announces the Selection of Parsons as the Lead Design-Build Contractor for the Proposed Depleted Uranium De-Conversion Facility 2International Isotopes Inc. Announces the Selection of Parsons as the Lead Design-Build Contractor for the Proposed Depleted Uranium De-Conversion Facility 3International Isotopes Inc. Announces the Selection of Parsons as the Lead Design-Build Contractor for the Proposed Depleted Uranium De-Conversion Facility 4