Navigation Links
Slicing proteins with Occam's Razor
Date:9/30/2010

ys.

Shaped a bit like a tennis racket over a basket, this tiny arm of the protein moves, through thermal fluctuations, to open or close the binding site near the myoglobin's iron-filled center. "As the atoms move in one direction it becomes easier to bind oxygen," says DeWitt, "and as they move in the reverse direction it becomes less easy."

And how this distal histidine moves should vary between the whale and the cheetah. "I would imagine," says Kelvin Chu, associate professor of physics and DeWitt's co-author, "that there has been evolutionary pressure on every species to adapt this motion in the myoglobin for their particular oxygen-binding needs."

"That's a testable hypothesis," Chu says. "What we would expect to see across species is that the tennis rackets are in different places or move different amounts."

DeWitt and Chu's work extends far beyond myoglobin. The two physicists see broad application of their new method in creating custom-crafted proteins.

"Once you know what these motions are and what the important atoms are," says Chu, "you can make mutants of proteins that have different binding attributes." And these different attributes have promise in developing new biotechnologies "ranging from blood substitutes to organic solar cells," he says.

Proteins are a cell's heavy laborers: hauling water, taking out the trash, carrying in the groceries -- and trillions of other tasks that make life. But how the shape of a protein determines its function remains one of the most vexing and important questions in the physics of biology.

Proteins are not the static, Lego-like objects you might see in an x-ray photograph in a biochemistry textbook. Instead, made from long chains of amino acids scrunched into various blobs and globs, a protein is always jumping between slightly different structural arrangements due to thermal motion of its atoms. Even a modest-sized protein like myoglobin has more possible
'/>"/>

Contact: Joshua Brown
joshua.e.brown@uvm.edu
802-656-3039
University of Vermont
Source:Eurekalert  

Page: 1 2 3 4

Related biology news :

1. Slicing chromosomes leads to new insights into cell division
2. Scripps Research scientists win $65 million in new grants to reveal form and function of proteins
3. RD114 envelope proteins provide an effective and versatile approach to pseudotype lentiviral vectors
4. UCLA receives $12.5M to lead international project to study proteins implicated in heart disease
5. NIH grants will advance studies of the form and function of proteins
6. Purifying proteins: Rensselaer researchers use NMR to improve drug development
7. Proteins to yield new clues in fight against osteoporosis
8. UT Health Science Center San Antonio lands $11.6 million to study cardiac proteins
9. Proteins linked with Alzheimers, other neurodegenerative diseases found to clump in normal aging
10. $22.5 million grant funds international study of membrane proteins
11. Nanoblasts from laser-activated nanoparticles move molecules, proteins and DNA into cells
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Slicing proteins with Occam's Razor
(Date:8/4/2015)... 04, 2015 ... announced the addition of the "Digital ... Service), Sub-Segment (Computer Forensics, Network Forensics, Mobile ... Service, Vertical and Region - Global Forecast ... By Component (Hardware, Software, and ...
(Date:7/31/2015)... de 2015 A 10 a. Conferência ... pela BGI de 22-25 de outubro de 2015, em ... conferência está celebrando seu 10 o. aniversário este ano. ... uma das reuniões mais influentes do mundo no ramo ... entusiastas e prazerosos. A ICG-10 se ...
(Date:7/31/2015)... July 31, 2015 The 10 th International ... by BGI from October 22-25, 2015, in Shenzhen ... conference is celebrating its 10 th anniversary this year. Since ... world,s most influential annual meetings in the ,omics, fields, and ... gatherings. ICG-10 focuses on recent breakthroughs and ...
Breaking Biology News(10 mins):Digital Forensics Market - The Market Represents a Compound Annual Growth Rate (CAGR) of 11.3% From 2015 to 2020 2A 10a. Conferência Internacional sobre Genômica (ICG-10) será em outubro 2A 10a. Conferência Internacional sobre Genômica (ICG-10) será em outubro 3The 10th International Conference on Genomics (ICG-10) to Open in October 2
... The Human Microbiome Project has awarded more than $42 million to ... live in or on our bodies affect our health, the National ... microbiome is all the microorganisms that reside in or on the ... in 2007 as part of the NIH Common Fund,s Roadmap for ...
... 2009 Chronix Biomedical today reported that a new ... diagnostic and prognostic utility of using circulating fragments of ... fragments, referred to as serum DNA, are released into ... process. Chronix Biomedical has developed proprietary technology that can ...
... , -- Results from Parascript SignatureXpert confirm that signatures ... Court of Moscow to initiate forensic examination and expert ... , BOULDER, Colo., June 22 Parascript, ... today announced that it has partnered with the Moscow ...
Cached Biology News:NIH expands Human Microbiome Project; funds sequencing centers and disease projects 2NIH expands Human Microbiome Project; funds sequencing centers and disease projects 3NIH expands Human Microbiome Project; funds sequencing centers and disease projects 4NIH expands Human Microbiome Project; funds sequencing centers and disease projects 5Study shows Chronix technology using serum DNA can identify early presence of disease 2Parascript Signature Verification Technology Used by Moscow Law Firm to Detect Signature Fraud in $160,000 Debt Collection Case 2Parascript Signature Verification Technology Used by Moscow Law Firm to Detect Signature Fraud in $160,000 Debt Collection Case 3
(Date:8/27/2015)... , Aug. 27, 2015 In response ... FedEx, UPS and The US Postal Service to ... classified as ,select agents, by the CDC, Marken ... handling these sensitive shipments. Marken uses ... regulations, trained and certified personnel to ensure the ...
(Date:8/26/2015)... /PRNewswire/ - iCo Therapeutics ("iCo" or "the Company") (TSX-V: ... the quarter ended June 30, 2015. Amounts, unless ... presented under International Financial Reporting Standards ("IFRS"). ... our Oral Amp B program, rapidly advancing towards ... Andrew Rae , President & CEO of iCo ...
(Date:8/26/2015)... 26, 2015  The Diabetes Research Institute (DRI), ... Miami Miller School of Medicine, announced today that ... test for the first time a novel transplant ... FDA approved Phase I/II study builds upon decades ... an important first step toward the development of ...
(Date:8/26/2015)... August 26, 2015 Israel Proves Its Place ... 1 st place  Wayerz comes in 5 th ... Israel by venture capital fund JVP, with Chinese consulting ... China , Israel , ... Impressive achievement for the Israeli representatives in the final ...
Breaking Biology Technology:Marken Ensures Safe Transportation Of Select Agents And Toxins 2iCo Therapeutics Announces Second Quarter 2015 Financial Results 2iCo Therapeutics Announces Second Quarter 2015 Financial Results 3Diabetes Research Institute Successfully Transplants First Patient In Pilot BioHub Trial 2Diabetes Research Institute Successfully Transplants First Patient In Pilot BioHub Trial 3Diabetes Research Institute Successfully Transplants First Patient In Pilot BioHub Trial 4Israeli Startup Takes First Place at Shengjing Global Innovation Awards 2015 2Israeli Startup Takes First Place at Shengjing Global Innovation Awards 2015 3Israeli Startup Takes First Place at Shengjing Global Innovation Awards 2015 4Israeli Startup Takes First Place at Shengjing Global Innovation Awards 2015 5Israeli Startup Takes First Place at Shengjing Global Innovation Awards 2015 6
... Deliver Electronic X-ray-Based, Therapy Directly to ... SUNNYVALE, Calif., March 17 Xoft, ... clearance from the U.S. Food & Drug,Administration ... a,proprietary technology platform designed to deliver localized,non-radioactive, ...
... poised to ... MENLO PARK, Calif., March 17 Apieron, Inc., ... has received,clearance to market by the U.S. Food and ... nitric oxide (eNO), which is a,well-established indicator of airway ...
... -, SAN DIEGO, Calif., March 17 BioMed ... its board of directors has,declared a first quarter 2008 ... increase over the company,s previous quarterly dividend of $0.31,per ... dividend,of $1.34 per common share., BioMed also announced ...
Cached Biology Technology:FDA Clears Expanded Use of Xoft's Axxent(R) Electronic Brachytherapy System for all Radiation Therapy Indications 2Apieron, Inc. Announces FDA Clearance of the Insight(TM) eNO System to Assist Physicians with Patient Asthma Management 2Apieron, Inc. Announces FDA Clearance of the Insight(TM) eNO System to Assist Physicians with Patient Asthma Management 3BioMed Realty Trust Announces Increase in Quarterly Common Stock Dividend 2
Liquid. PBS containing 10 mM NaN 3 . AVOID FREEZE/THAW CYCLES. Recognizes α1, 2, 3, 5, 6 and 7 subunits of 20S proteasome. ...
Anti-TNKS2 Polyclonal AntibodyOther Sub-Family: not assigned-Other Applications: ELISA, Western Blot...
Rabbit Anti-Human Janus Kinase 2 (JAK2 Polyclonal Antibody Family: Protein Kinase Sub-Family: TYK2/JAK Applications: ELISA, Western Blot...
Goat polyclonal to Lipocalin 2...
Biology Products: