Navigation Links
Slicing chromosomes leads to new insights into cell division
Date:5/29/2009

ANN ARBOR, Mich.By using ultrafast laser pulses to slice off pieces of chromosomes and observe how the chromosomes behave, biomedical engineers at the University of Michigan have gained pivotal insights into mitosis, the process of cell division.

Their findings could help scientists better understand genetic diseases, aging and cancer.

Cells in plants, fungi, and animalsincluding those in the human bodydivide through mitosis, during which the DNA-containing chromosomes separate between the resulting daughter cells. Forces in a structure called the mitotic spindle guide the replicated chromosomes to opposing sides as one cell eventually becomes two.

"Each cell needs the right number of chromosomes. It's central to life in general and very important in terms of disease," said Alan Hunt, an associate professor in the Department of Biomedical Engineering and an author of a paper describing these findings published in Current Biology.

"One of the really important fundamental questions in biology is how do chromosomes get properly segregated when cells divide. What are the forces that move chromosomes around during this process? Where do they come from and what guides the movements?"

Hunt's results validate the theory that "polar ejection forces" are at play. Scientists had hypothesized that the direction and magnitude of these forces might provide physical cues guiding chromosome movements. In this capacity, polar ejection forces would play a central role separating chromosomes in dividing cells, but no one had established a direct link until now.

Polar ejection forces are thought to arise out of the interaction between protein motors on the arms of chromosomes that push against cells' microtubules. Microtubules are long, thin tubes that form a central component of the cytoskeleton and the mitotic spindle. They serve as intracellular structural supports and as railways along which molecular motors move c
'/>"/>

Contact: Nicole Casal Moore
ncmoore@umich.edu
734-647-1838
University of Michigan
Source:Eurekalert

Page: 1 2

Related biology news :

1. Slicing solar power costs
2. Grant supports study of abnormal ring-shaped chromosomes
3. Fungi can tell us about the origin of sex chromosomes
4. Cold Spring Harbor Protocols features classic approaches for analyzing chromosomes
5. UGA researchers discover mechanism that explains how cancer enzyme winds up on ends of chromosomes
6. Exploding chromosomes fuel research about evolution of genetic storage
7. Keeping chromosomes from cuddling up
8. How chromosomes meet in the dark -- Switch that turns on X chromosome matchmaking
9. Evolutionary origin of bacterial chromosomes revealed
10. Meth exposure in young adults leads to long-term behavioral consequences
11. Seattle Childrens Hospital leads $23.7 million NIH grant to study gene repair
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/13/2015)... , Feb. 13, 2015 ACT ... company that aims to transform cancer genomic information ... that the company has raised US$ 8 million in ... Based in Taipei, Taiwan , ... ACTDrug™, ACTOnco™. With the aim to implement next ...
(Date:2/9/2015)... , Feb. 9, 2015  Lintec of America recently ... for carbon nanotube (CNT) macrostructures, including sheets, yarns and ... (UTD). Leveraging the vast industrial resources of ... Japan , Lintec of America is forming the ... TX , focusing on scaling up the manufacturing ...
(Date:2/5/2015)... IRVINE, Calif. , Jan. 27, 2015 ... trusted provider of globally deployed, innovative test ... today announced the delivery of its ... Martin Space Systems Company (LMSSC). GENASYS is ... the demands of mission-critical applications that require ...
Breaking Biology News(10 mins):ACT Genomics Raises $8 Million in its First Private Funding Round 2Lintec announces exclusive license to commercialize innovative carbon nanotube technology from the University of Texas at Dallas 2Lintec announces exclusive license to commercialize innovative carbon nanotube technology from the University of Texas at Dallas 3Lintec announces exclusive license to commercialize innovative carbon nanotube technology from the University of Texas at Dallas 4Marvin Test Solutions' GENASYS Platform Advances Mission-Critical Aerospace Production Test 2Marvin Test Solutions' GENASYS Platform Advances Mission-Critical Aerospace Production Test 3Marvin Test Solutions' GENASYS Platform Advances Mission-Critical Aerospace Production Test 4
... Studies on genetically engineered mice show that social stress ... atherosclerosis. Commonly used drugs to reduce blood pressure, however, ... a thesis presented at the University of Gothenburg, Sweden. ... is a correlation between psychosocial stress and the risk ...
... heart defects has been identified by a team of scientists, ... to new treatments for those affected by the conditions brought ... on identifying and studying the gene in zebrafish embryos, and ... studying the genetics of mice and people. "This ...
... 6, 2010 Parascript, LLC, the image analysis ... its Signature Xpert was awarded best performance ... Conference on Frontiers in Handwriting Recognition (ICFHR2010) in ... Parascript was among seven participants representing a total ...
Cached Biology News:Social stress leads to atherosclerosis 2Scientists find gene linked to congenital heart defect 2Scientists find gene linked to congenital heart defect 3Scientists find gene linked to congenital heart defect 4Parascript SignatureXpert Wins Forensic Signature Verification Competition 2
(Date:2/27/2015)... BOSTON , Feb. 27, 2015   PureTech ... identifying, inventing and commercializing disruptive products and technologies in ... Christopher Viehbacher , former CEO and Member of the ... Directors.  "It,s has been a pleasure ... very excited that we will be working together more ...
(Date:2/26/2015)... , Feb. 26, 2015 On behalf ... its affiliated companies, Wilentz, Goldman & Spitzer, P.A. ... secrets lawsuit against Genewiz Inc. in excess of $10 ... utilized GenScript,s trade secrets, and that it improperly hired ... an order denying motions for judgment notwithstanding the verdict, ...
(Date:2/26/2015)... , Feb. 26, 2015 /PRNewswire/ - SQI Diagnostics ... a life sciences company that develops and commercializes proprietary ... its financial and operational results for the fiscal first ... press release are in Canadian dollars (CAD), unless otherwise ... continued to win new business from our existing customers ...
(Date:2/26/2015)... JOLLA, Calif. , Feb. 26, 2015   ... a biopharmaceutical company leading the discovery and development of ... G. Xanthopoulos , Ph.D., President and Chief Executive Officer ... Cowen and Company 35 th Annual Healthcare Conference ... The conference is being held at the Boston Marriott ...
Breaking Biology Technology:Christopher Viehbacher, former CEO of Sanofi, Joins PureTech's Board of Directors 2Christopher Viehbacher, former CEO of Sanofi, Joins PureTech's Board of Directors 3Christopher Viehbacher, former CEO of Sanofi, Joins PureTech's Board of Directors 4Wilentz Client GenScript Awarded $10 Million in Trade Secrets Case Against Genewiz 2Wilentz Client GenScript Awarded $10 Million in Trade Secrets Case Against Genewiz 3SQI Diagnostics Reports First Quarter Financial Results 2SQI Diagnostics Reports First Quarter Financial Results 3SQI Diagnostics Reports First Quarter Financial Results 4SQI Diagnostics Reports First Quarter Financial Results 5SQI Diagnostics Reports First Quarter Financial Results 6Regulus to Present at Cowen and Company 35th Annual Healthcare Conference 2Regulus to Present at Cowen and Company 35th Annual Healthcare Conference 3
... - Vasogen Inc.,(NASDAQ: VSGN ; TSX:VAS), a biotechnology ... technologies targeting the chronic inflammation,underlying cardiovascular and neurological ... on Wednesday, January 16, 2008. A conference,call will ... management will,provide a Company update and discuss year-end ...
... (NYSE: CRY ),a biomaterials, medical device and tissue ... a lawsuit will be filed against it in,the Superior ... The lawsuit concerns an individual who contracted an ... 2006. Meniscal,transplants are commonly used for patients with significant ...
... Biomoda, Inc. (OTC,Bulletin Board: BMOD) ( http://www.biomoda.com ... Gomez has joined Biomoda as a Senior,Research Specialist ... for the early detection of lung cancer., ... research scientist at,Lovelace Respiratory Research Institute in Albuquerque. ...
Cached Biology Technology:Vasogen to Conduct Year-end 2007 Conference Call 2Vasogen to Conduct Year-end 2007 Conference Call 3Vasogen to Conduct Year-end 2007 Conference Call 4CryoLife Responds to Inaccurate Assertions from Plaintiff's Attorney 2CryoLife Responds to Inaccurate Assertions from Plaintiff's Attorney 3Biomoda Hires Senior Scientist to Expand Research & Development Effort 2
... Activated affinity media for spontaneous ligand immobilization can ... antibody, enzyme, antigen, or receptor to create an ... 15 supports couple ligands via primary amines. Affi-Gel ... pI from 6.5 to 11; Affi-Gel 15 gel ...
pH-dependent fluorescence; Maximum intensity observed in basic solutions....
Anti-Chicken IgY, (IgG) F(ab')2 Fragment Specific....
Presenilin 2 Immunogen: Synthetic peptide corresponding to residues 31-47 of human Presenilin 2. Storage: -20 C, Avoid Freeze/Thaw Cycles...
Biology Products: