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Slice, stack, and roll: A new way to build collagen scaffolds
Date:12/27/2012

his process produced a scaffold material with tensile strength stronger than constructs made using common processing techniques, Xu notes.

The researchers also created tubular scaffolding by rolling layers of collagen sheets around Teflon-coated glass rods. The sheets were layered so that fibers ran along the length and the circumference of the rods. This process yielded tubes that were found to be stronger than similar tubes made of reconstituted collagen. They also maintained their highly aligned fiber structure.

"Alignment gives the scaffold the ability to guide the direction and orientation of cell growth," says Xu, who also has a faculty appointment at Tufts School of Medicine, "This capability is beneficial for tissue engineering applications where biocompatibility and the ability to guide unidirectional nerve growth are both desired, such as prosthetic or tissue engineering-based blood vessels or nerve conduits."


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Contact: Alex Reid
Alexander.Reid@tufts.edu
617-627-4173
Tufts University
Source:Eurekalert  

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