Navigation Links
Slice, stack, and roll: A new way to build collagen scaffolds
Date:12/27/2012

MEDFORD/SOMERVILLE, Mass. (December, 26 2012) Tufts University School of Engineering researchers have developed a novel method for fabricating collagen structures that maintains the collagen's natural strength and fiber structure, making it useful for a number of biomedical applications.

Collagen, the most abundant protein in the body, is widely used to build scaffolds for tissue engineering because it is biocompatible and biodegradable. Collagen is, however, hard to work with in its natural form because it is largely insoluble in water, and common processing techniques reduce its strength and disrupt its fibrous structure.

The Tufts engineers' new technique, called bioskiving, creates collagen structures from thin sheets of decellularized tendon stacked with alternating fiber directions that maintain much of collagen's natural strength.

Bioskiving does not dilute collagen's natural properties, says Qiaobing Xu, assistant professor of biomedical engineering, and inventor of the new technique. "Our method leverages collagen's native attributes to take advantage of the well-organized micro/nanostructures that nature already provides," he says.

Xu and Kyle Alberti, a Ph.D. student in Xu's lab, describe their technology in the paper "Slicing, Stacking and Rolling: Fabrication of Nanostructured Collagen Constructs from Tendon Sections" published online in Advanced Healthcare Materials on December 12, 2012.

Slice, Stack, and Roll

In their research, Xu and Albert cut small sections of collagen from bovine tendons. Using a specialized detergent, the researchers decellularized the sections, leaving intact only the extracellular collagen matrix made of bundles of aligned collagen nanofibers.

Xu and Alberti sliced the sections into ultra-thin sheets using a microtome, and then stacked 10 slices, crisscrossing the sheets so that the fibers in one ran perpendicular to those above and below it. This process produced a scaffold material with tensile strength stronger than constructs made using common processing techniques, Xu notes.

The researchers also created tubular scaffolding by rolling layers of collagen sheets around Teflon-coated glass rods. The sheets were layered so that fibers ran along the length and the circumference of the rods. This process yielded tubes that were found to be stronger than similar tubes made of reconstituted collagen. They also maintained their highly aligned fiber structure.

"Alignment gives the scaffold the ability to guide the direction and orientation of cell growth," says Xu, who also has a faculty appointment at Tufts School of Medicine, "This capability is beneficial for tissue engineering applications where biocompatibility and the ability to guide unidirectional nerve growth are both desired, such as prosthetic or tissue engineering-based blood vessels or nerve conduits."


'/>"/>

Contact: Alex Reid
Alexander.Reid@tufts.edu
617-627-4173
Tufts University
Source:Eurekalert  

Related biology news :

1. Building the European Unions Natura 2000 -- the largest ever network of protected areas
2. Newly found protein helps cells build tissues
3. New study finds a protein combination is best to consume post-workout for building muscle
4. Heart study suggests city center pollution doubles risk of calcium build-up in arteries
5. Light weights are just as good for building muscle, getting stronger, researchers find
6. UC Santa Cruz builds national data center for cancer genome research
7. CUNY Energy Institute battery system could reduce buildings electric bills
8. A cells first steps: Building a model to explain how cells grow
9. Stealing lifes building blocks
10. Blood-brain barrier building blocks forged from human stem cells
11. Building global collaboration for biodiversity intelligence
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Slice, stack, and roll: A new way to build collagen scaffolds
(Date:11/29/2016)... Nearly one billion matches per second with DERMALOG,s high-speed AFIS    ... ... DERMALOG is Germany's largest Multi-Biometric supplier: The company's ... Systems) ... largest Multi-Biometric supplier: The company's Fingerprint Identification System is part of an ...
(Date:11/22/2016)... 22, 2016   MedNet Solutions , an innovative ... of clinical research, is pleased to announce that the ... and Life Sciences Awards as "Most Outstanding in ... unprecedented year of recognition and growth for MedNet, which ... years. iMedNet ™ , MedNet,s ...
(Date:11/17/2016)... 17, 2016  AIC announces that it has just released a new white paper ... high-performance scale-out plus high speed data transfer storage solutions. Photo - ... ... ... Setting up a high performance computing or HPC ...
Breaking Biology News(10 mins):
(Date:12/4/2016)... ... December 02, 2016 , ... ... and -operated small businesses in federally funded research and development is welcome news ... for optics and photonics . , As part of the National Defense Authorization ...
(Date:12/4/2016)... SAN DIEGO , Dec. 3, 2016  In ... Society of Hematology (ASH) Annual Meeting and Exposition in ... advanced biomedical engineering methods to improve the delivery of ... conditions. These new methods are designed to carry therapies ... are needed most, which could provide a substantial advantage ...
(Date:12/2/2016)... ... 2016 , ... In anticipation of AxioMed’s exclusive cleanroom manufacturing ... President, Jake Lubinski will be traveling to Switzerland from December 5-10. Mr. Lubinski ... and Zurich to discuss the benefits of a viscoelastic disc. AxioMed received CE ...
(Date:12/2/2016)... -- The Multiple Myeloma Research Foundation (MMRF) today announced that ... —the largest and most comprehensive study driving new genomic ... presented at the 58 th American Society of ... San Diego from December 3-6. The new ... as identify pathways and targets for new drug development. ...
Breaking Biology Technology: