Navigation Links
Slice, stack, and roll: A new way to build collagen scaffolds
Date:12/27/2012

MEDFORD/SOMERVILLE, Mass. (December, 26 2012) Tufts University School of Engineering researchers have developed a novel method for fabricating collagen structures that maintains the collagen's natural strength and fiber structure, making it useful for a number of biomedical applications.

Collagen, the most abundant protein in the body, is widely used to build scaffolds for tissue engineering because it is biocompatible and biodegradable. Collagen is, however, hard to work with in its natural form because it is largely insoluble in water, and common processing techniques reduce its strength and disrupt its fibrous structure.

The Tufts engineers' new technique, called bioskiving, creates collagen structures from thin sheets of decellularized tendon stacked with alternating fiber directions that maintain much of collagen's natural strength.

Bioskiving does not dilute collagen's natural properties, says Qiaobing Xu, assistant professor of biomedical engineering, and inventor of the new technique. "Our method leverages collagen's native attributes to take advantage of the well-organized micro/nanostructures that nature already provides," he says.

Xu and Kyle Alberti, a Ph.D. student in Xu's lab, describe their technology in the paper "Slicing, Stacking and Rolling: Fabrication of Nanostructured Collagen Constructs from Tendon Sections" published online in Advanced Healthcare Materials on December 12, 2012.

Slice, Stack, and Roll

In their research, Xu and Albert cut small sections of collagen from bovine tendons. Using a specialized detergent, the researchers decellularized the sections, leaving intact only the extracellular collagen matrix made of bundles of aligned collagen nanofibers.

Xu and Alberti sliced the sections into ultra-thin sheets using a microtome, and then stacked 10 slices, crisscrossing the sheets so that the fibers in one ran perpendicular to those above and below it. T
'/>"/>

Contact: Alex Reid
Alexander.Reid@tufts.edu
617-627-4173
Tufts University
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Building the European Unions Natura 2000 -- the largest ever network of protected areas
2. Newly found protein helps cells build tissues
3. New study finds a protein combination is best to consume post-workout for building muscle
4. Heart study suggests city center pollution doubles risk of calcium build-up in arteries
5. Light weights are just as good for building muscle, getting stronger, researchers find
6. UC Santa Cruz builds national data center for cancer genome research
7. CUNY Energy Institute battery system could reduce buildings electric bills
8. A cells first steps: Building a model to explain how cells grow
9. Stealing lifes building blocks
10. Blood-brain barrier building blocks forged from human stem cells
11. Building global collaboration for biodiversity intelligence
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Slice, stack, and roll: A new way to build collagen scaffolds
(Date:12/17/2014)... 16, 2014  Automation is fundamentally transforming the ... than at international borders. Over the past decade, ... allowed veteran travelers to self process through border ... Kiosks at an increasing number of airports, seaports, ... According to Maxine Most , Principal ...
(Date:12/11/2014)... 10, 2014  Data Sciences International (DSI), the ... a new series of digital telemetry implants to ... M series, part of the PhysioTel™ Digital platform, ... possible physiologic data when incorporating functional endpoints into ... to toxicology studies has evolved from short ECG ...
(Date:12/10/2014)... 2014 Research and Markets ( ... "Biometrics Market in Japan 2014-2018" report ... http://photos.prnewswire.com/prnh/20130307/600769 The integration of biometrics ... banking and upgradation of the driver,s license is ... market. Besides the aforementioned projects, biometrics is being ...
Breaking Biology News(10 mins):Automated Border Control (ABC) Transforms the Global Travel Experience With More Than 2500 ABC eGates and APC Kiosks Deployed In Airports, Seaports, and Land Borders Worldwide 2New telemetry implants expected to change how large animal toxicology studies are conducted 2Biometrics Market in Japan 2014-2018: Key Vendors are DDS, Fujitsu, Hitachi and NEC 2
... What began as a summer internship project designed for an ... the deadliest, but little known viruses. Researchers at The Scripps ... key protein in the Nipah virus, which could pave the ... "This structure shows how key pieces of the virus,s machinery ...
... National Laboratories will use their expertise in protein ... of a multiproject, $34 million effort by the ... advanced biocatalyst technologies that can convert natural gas ... program is Reducing Emissions using Methanotrophic Organisms for ...
... of Illinois anthropology professor Ripan Malhi looks ... came to the Americas and what happened to them once they ... the meeting, " Ancient DNA: The First Three Decades ," at ... Malhi, an affiliate of the Institute for Genomic Biology at ...
Cached Biology News:Researchers capture structure of key part of deadly Nipah virus 2Researchers capture structure of key part of deadly Nipah virus 3Converting natural gas to liquid transportation fuels via biological organisms 2Converting natural gas to liquid transportation fuels via biological organisms 3Ancient, modern DNA tell story of first humans in the Americas 2
(Date:12/22/2014)... Dec. 22, 2014  ( www.competitivehealth.com ) — Competitive ... medical bill review and advocacy service, has signed an ... WellCard Savings discount health services marketplace. 63% ... more than they expected to pay. As part of ... costs, WellCard Savings is pleased to offer medical bill ...
(Date:12/22/2014)... 22, 2014 Fertility Associates of Memphis ... Bank USA , a network of more than 20 ... partnership, patients have fast access to a national pool ... IVF . Fertility Associates of Memphis is the only ... treatment option. , Dr. William Kutteh , director ...
(Date:12/19/2014)... BioPlus Specialty Pharmacy (BioPlus), one ... of Nick Maroulis, Pharm.D. to the newly created position ... In this position, Dr. Maroulis will continue to manage ... of our multi-site pharmacies as the company expands. Dr. ... that time he has served in many different capacities ...
(Date:12/19/2014)... Dec. 19, 2014 Bina Technologies, Inc. (Bina, ... that they have been acquired by Roche (SIX: RO, ... privately held company that provides a big data platform ... (NGS) data for the academic and translational research markets. ... and will continue to focus on development of their ...
Breaking Biology Technology:WellCard Savings Announces CoPatient Medical Bill Review Service for Members 2Fertility Associates of Memphis Announces Partnership with Donor Egg Bank USA 2Fertility Associates of Memphis Announces Partnership with Donor Egg Bank USA 3BioPlus Specialty Pharmacy Promotes Dr. Nick Maroulis to Vice President of Specialty Pharmacy Services 2Bina Technologies is acquired by Roche. 2Bina Technologies is acquired by Roche. 3
... atomic force microscopy (AFM) has emerged as a powerful ... nanometer in some cases. But suppose you,re more concerned ... National Institute of Standards and Technology (NIST) have shown ... as the AFM can deliver valuable data about sub-surface ...
... release is available in German . When light ... particles, so-called photons, carry sufficient energy, the electrons can be ejected ... explained by Einstein more than hundred years ago. Until now, it ... atom immediately after the impact of the photon. This point in ...
... ... SCD Probiotics has released a case study that provides a sustainable ... documented evidence of the effectivness of beneficial microbial applications. These results ... the Environmental Protection Agency, who recently agreed to identify and ...
Cached Biology Technology:Depth charge: Using atomic force microscopy to study subsurface structures 2Delayed time zero in photoemission 2Delayed time zero in photoemission 3Effective Odor and Pathogen Control in Livestock Operations Revealed in New Case Study 2
... Goat polyclonal to Cholesterol Oxidase ... / Specificity Cross-reacts with bacteria. Not ... Information Cholesterol oxidases exist as both ... are implicated in bacterial pathogenesis. In addition, ...
Phospho-PERK (Thr980) Antibody...
Goat polyclonal to BACE1 ( Abpromise for all tested applications). entrezGeneID: 23621 SwissProtID: P56817...
Sheep polyclonal to Staphylococcus DNase ( Abpromise for all tested applications). Antigen: Full length native protein (purified)....
Biology Products: