Navigation Links
Sleeping Trojan horse to aid imaging of diseased cells
Date:2/17/2011

A unique strategy developed by researchers at Cardiff University is opening up new possibilities for improving medical imaging.

Medical imaging often requires getting unnatural materials such as metal ions into cells, a process which is a major challenge across a range of biomedical disciplines. One technique currently used is called the 'Trojan Horse' in which the drug or imaging agent is attached to something naturally taken up by cells.

The Cardiff team, made of researchers from the Schools of Chemistry and Biosciences, has taken the technique one step further with the development of a 'sleeping Trojan horse'. The first example of its kind, this is delivery system resolves some of the current difficulties involved in transporting metal ions into cells.

It is not itself taken up by cells so does not interfere with natural functions until it is 'woken' by the addition of the metal ions. This minimises the unwanted uptake and need for time-consuming purification associated with the common 'Trojan Horse' technique.

The research was led by Dr Mike Coogan, Senior Lecturer in Synthetic Chemistry, along with the paper's first author, Flora Thorp-Greenwood.

Dr Coogan said: "The sleeping Trojan horse process happens rapidly, and the vessel is capable of carrying metals which have positron-emitting isotopes, so it has potential for use in bimodal fluorescence and PET imaging. Combined agents for these types of imaging are known but rare, so this is a significant development in the field.

"There is also additional potential for use in radiotherapy as the metal-bearing form not only enters cells but also localises in the nucleolus. In principle, the concept could also be used to improve delivery of a huge range of drugs and imaging agents into cells or the body."

The study A 'Sleeping Trojan Horse' which transports metal ions into cells, localises in nucleoli, and has potential for bimodal fluorescence/PET imaging is published in the advanced article section of Chemical Communications. Published by the Royal Society of Chemistry, this is the leading weekly journal for the publication of important developments in the chemical sciences.


'/>"/>

Contact: Dr. Mike Coogan
cooganmp@cf.ac.uk
44-292-087-4066
Cardiff University
Source:Eurekalert

Related biology news :

1. Emotion and scent create lasting memories -- even in a sleeping brain
2. Dog owners more likely to share germs with pets by not washing hands than by sleeping with dog
3. Sleeping Beauty -- Molecule of the Year
4. Scientists hope to end sleeping sickness by making parasite that causes it self-destruct
5. Sleeping Beauty hooks up with herpes to fight brain disease
6. Biologists identify genes regulating sleeping and feeding
7. Trojan Horse attack on native lupine
8. Trojan Horse ploy to sneak protective drug into brains of stroke patients
9. Stem cell research to benefit horse owners and trainers
10. Queens University Belfast works to save Strangford horse mussels
11. Decline of shorebird linked to bait use of horseshoe crabs
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/6/2017)... May 5, 2017 RAM Group ... a new breakthrough in biometric authentication based on ... mechanical properties to perform biometric authentication. These new sensors ... material created by Ram Group and its partners. This ... transportation, supply chains and security. Ram Group is ...
(Date:4/13/2017)... Calif. , April 13, 2017 UBM,s ... York will feature emerging and evolving technology ... Both Innovation Summits will run alongside the expo portion ... speaker sessions, panels and demonstrations focused on trending topics ... largest advanced design and manufacturing event will take place ...
(Date:4/11/2017)... , April 11, 2017 NXT-ID, ... security technology company, announces the appointment of independent Directors Mr. ... to its Board of Directors, furthering the company,s corporate ... ... NXT-ID, we look forward to their guidance and benefiting from ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... ... October 12, 2017 , ... ... the first-ever genomics analysis platform specifically designed for life science researchers to ... of pioneering researcher Rosalind Franklin, who made a major contribution to the ...
(Date:10/11/2017)... LINDA, CA (PRWEB) , ... October 11, 2017 ... ... to upregulate any gene in its endogenous context, enabling overexpression experiments and avoiding ... (CRISPRa) system with small RNA guides is transformative for performing systematic gain-of-function studies. ...
(Date:10/11/2017)... ... 2017 , ... ComplianceOnline’s Medical Device Summit is back for its 4th year. ... San Francisco, CA. The Summit brings together current and former FDA office bearers, regulators, ... government officials from around the world to address key issues in device compliance, quality ...
(Date:10/11/2017)... 11, 2017  VMS BioMarketing, a leading provider of patient ... Clinical Nurse Educator (CNE) network, which will launch this week. ... among health care professionals to enhance the patient care experience ... and other health care professionals to help women who have ... ...
Breaking Biology Technology: