Navigation Links
Sleeping Beauty hooks up with herpes to fight brain disease
Date:1/8/2010

Neuroscientists have forged an unlikely molecular union as part of their fight against diseases of the brain and nervous system.

The team has brought together the herpes virus and a molecule known as Sleeping Beauty to improve a technology known as gene therapy, which aims to manipulate genes to correct for molecular flaws that cause disease.

The work, detailed in a paper published online in Gene Therapy, has allowed scientists at the University of Rochester Medical Center to reach a long-sought goal: Shuttling into brain cells a relatively large gene that can remain on for an extended period of time.

"We've broken what is in effect a size barrier a limit to how much genetic material we can put into the nucleus of a cell and keep functioning for a long period of time," said neuroscientist William Bowers, Ph.D., a scientist in the Center for Neural Development and Disease and the leader of the team. "That opens up more diseases to possible treatment with gene therapy."

The first author of the paper is Biochemistry graduate student Suresh de Silva, who defends his doctoral thesis later this month.

The molecular rendezvous of Sleeping Beauty and herpes in human brain cells could spell good news in the search for treatments for horrific brain diseases known as pediatric leukodystrophies, or a group of diseases known as lysosomal storage disorders. In many of these diseases, even though just a single gene or protein is defective, the effects are devastating the diseases slowly rob children of their brain cells and are often fatal after years of severe symptoms.

The findings bolster the tools that researchers have when approaching certain diseases, said Bowers, including Usher syndrome, which results in deafness and vision loss; Niemann-Pick disease Type C, a fatal childhood lysosomal storage disorder; and von Willebrand disease, an inherited disease that causes extensive, chronic bleeding.

"The
'/>"/>

Contact: Tom Rickey
tom_rickey@urmc.rochester.edu
585-275-7954
University of Rochester Medical Center
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Emotion and scent create lasting memories -- even in a sleeping brain
2. Dog owners more likely to share germs with pets by not washing hands than by sleeping with dog
3. Scientists discover important beauty secret for balanced skin color and tone
4. Penn researchers shine the light of venus to learn how the herpes virus invades cells
5. Herpes virus link to complications in pregnancy
6. Herpes drug inhibits HIV in patients infected with both viruses
7. Potential new herpes therapy studied
8. Herpes virus: To vaccinate or not to vaccinate
9. Clemson chemists discover new way antioxidants fight debilitating diseases
10. Social habits of cells may hold key to fighting diseases
11. Advance in effort to fight malaria by tricking the mosquitos sense of smell
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/29/2014)... researchers sometimes need to get back to basics. ... to study the impacts of the bumphead parrotfish ... at two remote locations in the central Pacific ... computer simulation, McCauley, an assistant professor in the ... his colleagues sought to understand whether the world,s ...
(Date:7/29/2014)... recover from the debilitating effects of a stroke ... knowledge of neurophysiology as well as effective therapy. ... outcomes has been the primary focus of research ... since he joined the NJIT faculty more than ... is underscored by substantial funding from sources such ...
(Date:7/29/2014)... The University of Maryland Schools of Dentistry (UM ... that they have received a five-year $10.7 million ... and Infectious Diseases (NIAID) of the National Institutes ... treatment of sexually-transmitted diseases (STDs). The grant, which ... program, represents a new direction for the research ...
Breaking Biology News(10 mins):Underwater elephants 2Underwater elephants 3Continuing the quest for better stroke therapies 2Continuing the quest for better stroke therapies 3University of Maryland Schools of Dentistry and Medicine receive NIH grant 2University of Maryland Schools of Dentistry and Medicine receive NIH grant 3University of Maryland Schools of Dentistry and Medicine receive NIH grant 4
... Water runoff from cropped farm fields can contain ... of the fertilizer and herbicide. Expanding on existing conservation ... filters socks in grassed waterways would reduce sediment flow ... reduced sediment in a non-tilled field and reduced concentrations ...
... Institute have found a way to disable a common ... forms of cancer. The researchers discovered, surprisingly, that ... protein, called MCL-1, to make a molecular tool that ... to kill the tumor cells by apoptosis, or programmed ...
... Facility (ALCF), located at the U.S. Department of Energy,s ... processor-hours of computations at a mind-boggling speed of over ... and engineers to conduct cutting-edge research in just weeks ... dedicated to enabling breakthrough science science that will ...
Cached Biology News:Compost filter socks improve runoff from croplands 2Molecular discovery suggests new strategy to fight cancer drug resistance 2Molecular discovery suggests new strategy to fight cancer drug resistance 3Over two billion hours served 2
(Date:7/29/2014)... DisasterTalk is a texting app which allows ... masts or other transmitters are down. The app can transmit ... the need for any Wi-Fi, and can also use a ... app has launched as a housing report finds ... risk of being affected by natural disasters. With the risk ...
(Date:7/29/2014)... The first product launch from start-up Hurley ... robotics. What sets Droidles completely apart from other stand ... them to communicate, share code with each other and ... “The invention is the system,” said Hurley Research founder ... of their own, both physically and on the internet." ...
(Date:7/29/2014)... (PRWEB) July 29, 2014 White ... devices, and cloud based eClinical technologies, have been published ... Online. These follow a long line of white papers ... publications including Life Science Leader, Pharmaceutical Online, and OpenHealthNews. ... provided a paper by CTO Marc Desgrousilliers, 'The ...
(Date:7/28/2014)... July 28, 2014 Sapphire Energy, Inc. ... announced the appointment of biotechnology veteran James Levine ... of directors. Levine replaces Cynthia ,CJ, Warner, who is ... remain chairman of the company,s board of directors. ... mission to deliver commercial scale algae-based fuels has been ...
Breaking Biology Technology:DisasterTalk App Could Save Lives as Report Reveals 8% of US Homes at Very High Risk of Natural Disaster 2Droidles, the Social Network of Robots and Open Source Platform for the Internet of Things, Launches for Crowd Funding on IndieGoGo.com 2Clinovo White Papers Published in Summer 2014 Editions of Leading Medical Device & Pharmaceutical Publications 2Clinovo White Papers Published in Summer 2014 Editions of Leading Medical Device & Pharmaceutical Publications 3Sapphire Energy Announces New CEO James Levine 2Sapphire Energy Announces New CEO James Levine 3
... DIEGO, Dec. 9 BioMed Realty Trust, Inc. (NYSE: ... of the previously announced cash tender offer by its operating ... outstanding 4.50% Exchangeable Senior Notes due 2026 (the "Notes"). , ... 8, 2009, the scheduled expiration date of the tender offer, ...
... ... of its Brazilian regional office , ... Chicago, Ill. (Vocus) December 9, 2009 -- As part of ongoing ... Group, a world leader in the contaminated soil , sediment and groundwater ...
... , NEWTON, Mass., Dec. 8 ... announced that James N. Little, Ph.D., has informed the ... Directors effective December 31, 2009. Dr. Little has served ... appointed chairman on December 13, 2007. , (Logo: ...
Cached Biology Technology:BioMed Realty Announces Results of Tender Offer for its Exchangeable Notes 2BioMed Realty Announces Results of Tender Offer for its Exchangeable Notes 3Olympics 2016, World Cup 2014, But First – Adventus Brasil 2009 2Olympics 2016, World Cup 2014, But First – Adventus Brasil 2009 3Olympics 2016, World Cup 2014, But First – Adventus Brasil 2009 4Microfluidics Chairman James N. Little, Ph.D., Announces Retirement from Board of Directors 2Microfluidics Chairman James N. Little, Ph.D., Announces Retirement from Board of Directors 3
... 5 ml of DETACHaBEAD 19 polyclonal ... CD19 (Pan B). B cells ... and released with DETACHaBEAD CD19 are ... suitable for applications such as culturing ...
This Malachite Green Phosphate Detection Kit...
5-bromo-4-chloro-3-indolyl b -D-galactopyranoside (X-Gal)...
...
Biology Products: