Navigation Links
'Sleeping Beauty' -- Molecule of the Year
Date:1/19/2010

The jumping gene or "Sleeping Beauty" transposon is "Molecule of the Year 2009". This was announced by Professor Isidro T. Savillo, President of the International Society for Molecular and Cell Biology and Biotechnology Protocols and Researches (ISMCBBPR). The transposon was generated by Dr. Zsuzsanna Izsvk, Dr. Zoltn Ivics and Dr. Lajos Mts of the Max Delbrck Center for Molecular Medicine in Berlin-Buch. According to the jury, it was selected out of 15 molecules nominated in the contest because "this molecule holds great promise for gene therapy". The jury pointed out that it can stably transfer genes even to stem or progenitor cells and is safer than a viral vector. It is the first time that the Molecule of the Year has been awarded to major recipients outside the USA in Europe.

Transposable elements are molecular parasites that propagate themselves in genomes. But at the same time they provide plasticity to the genome that clearly contributed to the evolution of gene function across the tree of life. About half of the human genome is derived from ancient transposable element sequences.

However, due to mutations, the vast majority of the transposons became inactivated. Based on transposons in fish that are presumed to have been active approximately 20 million years ago, Dr. Ivics and Dr. Izsvk resurrected a jumping gene more than ten years ago. They named the transposon Sleeping Beauty, because they literally awakened it after a long evolutionary "sleep".

The scientists modified the originally reconstructed transposon so that it acquired a highly elevated potency in gene transfer. In its award citation, the jury noted that this hyperactive transposon promises to be a revolutionary technology platform for genetic engineering in vertebrates.

With their new tool, Dr. Izsvk and Dr. Ivics were able to introduce genes into cells of vertebrates at efficiencies previously seen only with viral vector systems. This was impossible
'/>"/>

Contact: Barbara Bachtler
bachtler@mdc-berlin.de
49-309-406-3896
Helmholtz Association of German Research Centres
Source:Eurekalert

Page: 1 2

Related biology news :

1. Scientists hope to end sleeping sickness by making parasite that causes it self-destruct
2. Sleeping Beauty hooks up with herpes to fight brain disease
3. Dog owners more likely to share germs with pets by not washing hands than by sleeping with dog
4. Emotion and scent create lasting memories -- even in a sleeping brain
5. Scientists discover important beauty secret for balanced skin color and tone
6. Small molecules found to protect cells in multiple models of Parkinsons disease
7. Emerald BioStructures announces discovery of small molecule modulators of PDE4
8. Scientists isolate new antifreeze molecule in Alaska beetle
9. Just like old times: Generating RNA molecules in water
10. Newly discovered fat molecule: An undersea killer with an upside
11. New synthetic molecules trigger immune response to HIV and prostate cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/20/2014)... could one day be made out of cocoa, rice ... reporting. The novel process they developed and their results, ... and plastic waste problems, appear in the ACS journal ... and colleagues at the Italian Institute of Technology point ... its production reached 288 million tons worldwide, but its ...
(Date:8/20/2014)... When a colony of honeybees grows to about 4,000 ... reproductive cycle: the building of a special type of ... team of experts from the Department of Neurobiology and ... what starts the reproductive cycle of honeybee colonies. The ... The Science of Nature . , Reproduction isn,t ...
(Date:8/20/2014)... and POINT ROBERTS, Washington , August 20, ... Key Role in Addressing Security Concerns in the Payment Industry? ... news source covering leading sectors including biometrics, issues commentary from ... Jason Peaslee , Managing Partner at Thrive Analytics, ... Gino Pereira , CEO of NXT-ID, Inc. (OTCBB: NXTD) ( ...
Breaking Biology News(10 mins):Worker bees 'know' when to invest in their reproductive future 2Digital Wallets for a Digital World - the Players and the Concerns for Consumer Adoption 2Digital Wallets for a Digital World - the Players and the Concerns for Consumer Adoption 3Digital Wallets for a Digital World - the Players and the Concerns for Consumer Adoption 4Digital Wallets for a Digital World - the Players and the Concerns for Consumer Adoption 5Digital Wallets for a Digital World - the Players and the Concerns for Consumer Adoption 6Digital Wallets for a Digital World - the Players and the Concerns for Consumer Adoption 7
... An in-depth study by Sandia National Laboratories and ... waste and dedicated energy crops could sustainably replace nearly ... The goal of the "90-Billion Gallon Biofuel ... large volume of cellulosic biofuel could be sustainably produced, ...
... that road salt used throughout the winter is making ... aquatic life and drinking water. The research indicates ... judicious use of road salt could help lessen the ... a video with research team leader Heinz Stefan, go ...
... elevations in Arizona,s Santa Catalina Mountains as summer temperatures ... Arizona in Tucson. The flowering ranges of 93 ... to where the same species flowered the previous ten ... the region increased about 1.8 degree Fahrenheit (1 degree ...
Cached Biology News:Biofuels can provide viable, sustainable solution to reducing petroleum dependence 2Biofuels can provide viable, sustainable solution to reducing petroleum dependence 3U of Minnesota research finds most road salt is making it into the state's lakes and rivers 2Plants take a hike as temperatures rise 2Plants take a hike as temperatures rise 3
(Date:8/20/2014)... August 20, 2014 The 6th ... being held on October 29-30 in San Francisco, CA. ... academic and government researchers and clinicians focused on addressing ... , In the twelve years since the sequencing ... have been introduced with pharmacogenetic information in the label ...
(Date:8/20/2014)... WriteResult®, a leading provider of Electronic Patient Outcome ... myPROpad™ ePRO tablet with the addition of a touchscreen ... widely used and well-respected Patient Reported Outcome (PRO) instruments ... used during clinical trials and in other health care ... to demonstrate Health-Related Quality of Life outcomes (HRQoL) resulting ...
(Date:8/19/2014)... Research and Markets  has announced the addition of the "Cell ... to their offering. This report analyzes the worldwide ... the following Product Segments: Media, Sera, and Reagents. The ... , Japan , Europe ... . Annual estimates and forecasts are provided for the period ...
(Date:8/19/2014)... (PRWEB) August 19, 2014 Robin Williams’ ... disease can take on an individual. Symptoms range ... facial expression, problems swallowing and severe depression. Parkinson’s ... dying off of dopamine producing neurons of the brain. ... a disease that slowly and progressively gets worse, they ...
Breaking Biology Technology:6th Annual Personalized and Precision Medicine Conference Bringing Together Thought Leaders to Discuss Clinical Implementation, Dx Reimbursement, Big Data, and Sequencing 2EQ-5D™ Assessment Now Available for iPad 2Global Cell and Tissue Culture Supplies - Strategic Business Report 2014 2As We Mourn Robin Williams’ Passing, His Death Sheds Light on Patients Struggling with Parkinson’s Disease 2As We Mourn Robin Williams’ Passing, His Death Sheds Light on Patients Struggling with Parkinson’s Disease 3
... Silence Therapeutics plc (AIM: SLN) ("Silence", the "Group" or ... company, today announces the appointment of Thomas Christély as ... based at Silence,s facility in Berlin. Thomas ... in corporate and business development and finance. He was ...
... researchers have developed a new technique to reach neurons ... and noninvasively. Up until now, scientists have thought that ... required. But in this new study, the Columbia Engineering ... can open the blood-brain barrierwith the added advantages of ...
... Korea, August 8, 2011Can a flexible LED conformably placed on ... human brain, or rolled upon the blood vessels, diagnose or ... in the near future. The team of Professor Keon ... developed a new concept: a biocompatible, flexible Gallium Nitride (GaN) ...
Cached Biology Technology:Appointment of Chief Executive Officer 2Appointment of Chief Executive Officer 3Appointment of Chief Executive Officer 4Engineers use short ultrasound pulses to reach neurons through blood-brain barrier 2
Mouse monoclonal [M7-PB-E9] to pan alpha Sodium Potassium ATPase ( Abpromise for all tested applications)....
Transcription factor Sp2. [Source:Uniprot/SWISSPROT;Acc:Q02086] Antigen: Recombinant Protein Epitope Signature Tag (PrEST)....
... [EP282Y] to Asparagine synthetase ( ... applications). Antigen: ... residues in the C-terminus of ... Entrez GeneID: 440 ...
Rabbit Anti-melatonin (different linkage) Polyclonal Antibody...
Biology Products: