Navigation Links
'Sleeping Beauty' -- Molecule of the Year
Date:1/19/2010

The jumping gene or "Sleeping Beauty" transposon is "Molecule of the Year 2009". This was announced by Professor Isidro T. Savillo, President of the International Society for Molecular and Cell Biology and Biotechnology Protocols and Researches (ISMCBBPR). The transposon was generated by Dr. Zsuzsanna Izsvk, Dr. Zoltn Ivics and Dr. Lajos Mts of the Max Delbrck Center for Molecular Medicine in Berlin-Buch. According to the jury, it was selected out of 15 molecules nominated in the contest because "this molecule holds great promise for gene therapy". The jury pointed out that it can stably transfer genes even to stem or progenitor cells and is safer than a viral vector. It is the first time that the Molecule of the Year has been awarded to major recipients outside the USA in Europe.

Transposable elements are molecular parasites that propagate themselves in genomes. But at the same time they provide plasticity to the genome that clearly contributed to the evolution of gene function across the tree of life. About half of the human genome is derived from ancient transposable element sequences.

However, due to mutations, the vast majority of the transposons became inactivated. Based on transposons in fish that are presumed to have been active approximately 20 million years ago, Dr. Ivics and Dr. Izsvk resurrected a jumping gene more than ten years ago. They named the transposon Sleeping Beauty, because they literally awakened it after a long evolutionary "sleep".

The scientists modified the originally reconstructed transposon so that it acquired a highly elevated potency in gene transfer. In its award citation, the jury noted that this hyperactive transposon promises to be a revolutionary technology platform for genetic engineering in vertebrates.

With their new tool, Dr. Izsvk and Dr. Ivics were able to introduce genes into cells of vertebrates at efficiencies previously seen only with viral vector systems. This was impossible before, as researchers previously lacked efficient transposon technologies to do so. Therefore, Sleeping Beauty was referred to as a breakthrough at the European Society of Gene and Cell Therapy Conference in Hannover, Germany in November 2009.

Since 2002 the Molecule of the Year has been awarded by the ISMCBBPR, which was founded in 2000. Prior to 2002 the award was conferred by the journal Science.


'/>"/>

Contact: Barbara Bachtler
bachtler@mdc-berlin.de
49-309-406-3896
Helmholtz Association of German Research Centres
Source:Eurekalert

Related biology news :

1. Scientists hope to end sleeping sickness by making parasite that causes it self-destruct
2. Sleeping Beauty hooks up with herpes to fight brain disease
3. Dog owners more likely to share germs with pets by not washing hands than by sleeping with dog
4. Emotion and scent create lasting memories -- even in a sleeping brain
5. Scientists discover important beauty secret for balanced skin color and tone
6. Small molecules found to protect cells in multiple models of Parkinsons disease
7. Emerald BioStructures announces discovery of small molecule modulators of PDE4
8. Scientists isolate new antifreeze molecule in Alaska beetle
9. Just like old times: Generating RNA molecules in water
10. Newly discovered fat molecule: An undersea killer with an upside
11. New synthetic molecules trigger immune response to HIV and prostate cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/21/2016)... Columbia , June 21, 2016 ... to the new role of principal product architect ... named the director of customer development. Both will ... chief technical officer. The moves reflect NuData,s strategic ... in response to high customer demand and customer ...
(Date:6/9/2016)... Paris Police Prefecture and ... ensure the safety of people and operations in several locations ... Teleste, an international technology group specialised in broadband ... its video security solution will be utilised by ... across the country. The system roll-out is scheduled for the ...
(Date:6/2/2016)... Perimeter Surveillance & Detection Systems, Biometrics & ... & Other Service  The latest report from ... of the global Border Security market . Visiongain ... billion in 2016. Now: In November 2015 ... and hardware technologies for advanced video surveillance. ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... 2016  Sequenom, Inc. (NASDAQ: SQNM ), ... through the development of innovative products and services, announced ... United States denied its petition to review ... Sequenom,s U.S. Patent No. 6,258,540 (",540 Patent") are not ... the Supreme Court,s Mayo Collaborative Services v. Prometheus Laboratories ...
(Date:6/27/2016)... ... June 27, 2016 , ... Rolf ... join the faculty of the University of North Carolina Kenan-Flagler Business School ... and entrepreneurship at UNC Kenan-Flagler, with a focus on the school’s international efforts, ...
(Date:6/24/2016)... SAN DIEGO , June 24, 2016 /PRNewswire/ ... that more sensitively detects cancers susceptible to PARP ... individual circulating tumor cells (CTCs). The new test ... of HRD-targeted therapeutics in multiple cancer types. ... therapies targeting DNA damage response pathways, including PARP, ...
(Date:6/23/2016)... ... June 23, 2016 , ... ... announce the launch of their brand, UP4™ Probiotics, into Target stores nationwide. The ... is proud to add Target to its list of well-respected retailers. This list ...
Breaking Biology Technology: