Navigation Links
'Sleeping Beauty' -- Molecule of the Year
Date:1/19/2010

The jumping gene or "Sleeping Beauty" transposon is "Molecule of the Year 2009". This was announced by Professor Isidro T. Savillo, President of the International Society for Molecular and Cell Biology and Biotechnology Protocols and Researches (ISMCBBPR). The transposon was generated by Dr. Zsuzsanna Izsvk, Dr. Zoltn Ivics and Dr. Lajos Mts of the Max Delbrck Center for Molecular Medicine in Berlin-Buch. According to the jury, it was selected out of 15 molecules nominated in the contest because "this molecule holds great promise for gene therapy". The jury pointed out that it can stably transfer genes even to stem or progenitor cells and is safer than a viral vector. It is the first time that the Molecule of the Year has been awarded to major recipients outside the USA in Europe.

Transposable elements are molecular parasites that propagate themselves in genomes. But at the same time they provide plasticity to the genome that clearly contributed to the evolution of gene function across the tree of life. About half of the human genome is derived from ancient transposable element sequences.

However, due to mutations, the vast majority of the transposons became inactivated. Based on transposons in fish that are presumed to have been active approximately 20 million years ago, Dr. Ivics and Dr. Izsvk resurrected a jumping gene more than ten years ago. They named the transposon Sleeping Beauty, because they literally awakened it after a long evolutionary "sleep".

The scientists modified the originally reconstructed transposon so that it acquired a highly elevated potency in gene transfer. In its award citation, the jury noted that this hyperactive transposon promises to be a revolutionary technology platform for genetic engineering in vertebrates.

With their new tool, Dr. Izsvk and Dr. Ivics were able to introduce genes into cells of vertebrates at efficiencies previously seen only with viral vector systems. This was impossible
'/>"/>

Contact: Barbara Bachtler
bachtler@mdc-berlin.de
49-309-406-3896
Helmholtz Association of German Research Centres
Source:Eurekalert

Page: 1 2

Related biology news :

1. Scientists hope to end sleeping sickness by making parasite that causes it self-destruct
2. Sleeping Beauty hooks up with herpes to fight brain disease
3. Dog owners more likely to share germs with pets by not washing hands than by sleeping with dog
4. Emotion and scent create lasting memories -- even in a sleeping brain
5. Scientists discover important beauty secret for balanced skin color and tone
6. Small molecules found to protect cells in multiple models of Parkinsons disease
7. Emerald BioStructures announces discovery of small molecule modulators of PDE4
8. Scientists isolate new antifreeze molecule in Alaska beetle
9. Just like old times: Generating RNA molecules in water
10. Newly discovered fat molecule: An undersea killer with an upside
11. New synthetic molecules trigger immune response to HIV and prostate cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/17/2014)... Dec. 16, 2014 Valencell, a leader in performance ... technology to industry leaders such as Intel, Jabra, Atlas, ... biometric wearable products. These products will be showcased at ... Las Vegas . "Our partners ...
(Date:12/11/2014)... , Dec. 09, 2014 Research and Markets ... ( http://www.researchandmarkets.com/research/twhjll/biometrics_market ) has announced the addition of the ... to their offering. One major trend ... continuous advances in technology, it is important to upgrade ...
(Date:12/10/2014)... YORK , Dec. 8, 2014 You,ve been here before: ... can,t remember your password, site key or the answer to your ... teacher? Today, Hoyos Labs , a digital ... put an end to the frustration that comes with usernames, passwords ...
Breaking Biology News(10 mins):Valencell PerformTek Biometrics Power the Most Accurate Wearables at CES 2015 2Biometrics Market in the APAC Region 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2The Password is Finally Dead: Launch of 1U Mobile App Eliminates Need for All Usernames and Passwords 2The Password is Finally Dead: Launch of 1U Mobile App Eliminates Need for All Usernames and Passwords 3
... existed in the Amazon before the arrival of Europeans, ... the result of research led by Crystal McMichael and ... The finding overturns the idea the Amazon was a ... that transformed vast tracts of the landscape. The ...
... vegetarian and ecological products, but is it really making ... about ethical trade, Gothenburg researchers Bengt Brlde and ... help ease people,s bad conscience, it does nothing to ... fixing the problem will require collective solutions, such as ...
... UC Santa Barbara scientists turned to the simple sponge to ... and found that, but for a mechanism that coordinates the ... synapses, sponges and the rest of the animal world may ... of a protosynaptic gene expression network," are published in the ...
Cached Biology News:Scientists reconstruct pre-Columbian human effects on the Amazon Basin 2Ethical trade: 'Good intentions go to waste' 2Clues to nervous system evolution found in nerve-less sponge 2
(Date:1/22/2015)... MA (PRWEB) January 22, 2015 zFlo ... is pleased to announce an exciting product from a new ... motion analysis solutions over the past 15 years, with offerings ... Most recently, their 3D IMU system (inertial measurement unit), iSen, ...
(Date:1/22/2015)... 2015 Selexis SA, a serial innovation ... Banks (RCBs) used for drug discovery to commercial manufacturing, ... include Next-Generation Sequencing (NGS) data packages. The ... manufacturing by ensuring the integrity of the gene, validation ...
(Date:1/22/2015)... Jan. 22, 2015   Cypher Genomics, Inc., ... (NASDAQ: SQNM ), the leading molecular ... next generation noninvasive prenatal tests (NIPT). Through this ... called Mantis™, to advance analysis of clinically-relevant fetal ...
(Date:1/22/2015)...  Derma Sciences, Inc. (Nasdaq: DSCI ), ... care, announces that AMNIOEXCEL® and AMNIOMATRIX®, amniotic allografts ... the Premier, Inc. Regenerative Skin Grafting contract portfolio. ... and AMNIOMATRIX® product lines, which continue to be ...
Breaking Biology Technology:3D Motion Capture Just Got Easy 2Selexis Generated Research Cell Banks Now Fully Sequenced Using Next-Generation Sequencing 2Cypher Genomics and Sequenom Announce Development Agreement 2Cypher Genomics and Sequenom Announce Development Agreement 3Cypher Genomics and Sequenom Announce Development Agreement 4Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 2Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 3Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 4Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 5
... LIVERPOOL, February 2 Gray Healthcare has ... to lead its,expanding Community Recovery Team, as Clinical Director. ... years, experience of senior management in mental,health in both the ... of operations at Cambian Healthcare, covering 12 psychiatric,rehabilitation hospitals, he ...
... SAN DIEGO , Feb. 1 BioMed Realty Trust, Inc. ... its fourth quarter and year ended December 31, 2009 after ... Alan D. Gold , Chairman and Chief Executive Officer, and ... conference call at 10:00 a.m. Pacific Time on Thursday, ...
... Astrogenetix ... Space Station (ISS) to 2020 or beyond. , ... (Vocus) February 1, 2010 -- Astrogenetix is issuing the following statement applauding ... beyond. , ,Thomas B. Pickens III, Chairman of Astrogenetix, Inc.:, , ,“We are excited to ...
Cached Biology Technology:Noel Tracey to Head Up Gray Healthcare Recovery Team 2BioMed Realty Trust to Report 2009 Fourth Quarter and Year-End Results 2Astrogenetix Statement On Nasa's Fiscal Year 2011 Budget Announcement 2
... Polyclonal Phosphorylated Anti-GluR1 Glutamate is the ... many years it had been considered to ... NMDA, AMPA and kainate receptors that are ... Recently, glutamate has been shown to regulate ...
Anti-ADP-Ribosylation Factor 1, clone 3F1 Immunogen: Synthetic peptide corresponding to the C-terminal amino acid sequence of human ARF1. Available Date: 38495...
TNF-Related Apoptosis Inducing Ligand-Receptor-1...
Pim-1 (12H8)...
Biology Products: