Navigation Links
Skywalker ensures optimal communication between neurons
Date:4/1/2011

"I hope that unraveling the way Skywalker works will not only teach us more about the way neurons communicate with each other but will also lead to new diagnostics and therapies for neurological diseases such as Parkinson's," says Verstreken.

Communication between brain cells

Brain disorders take a major toll on society. More than 8% of the population in the West depends on analgesics. Twenty per cent suffers from a mental disturbance and the number of people suffering from the effects of neurological diseases is estimated at 1 billion. Many of these problems are caused by the disruption of communication between brain cells. Hence, finding a solution depends on understanding this communication in the smallest details.

Communication between brain cells occurs at the synapses, where an electrical signal is passed via a vesicle (a small membrane-enclosed sac with signaling substances). The vesicle releases the signaling substances, thus activating another brain cell.

An eye for the proper balance

The vesicles are reused several times. This results in the gradual degradation of the proteins they need for carrying out their function properly, which in turn affects the release of signaling substances. How the vesicles are kept operational during this recycling process was a mystery until now. Most types of cells have incorporated an extra step into this recycling process via special cell compartments called endosomes. In the endosomes, vesicle proteins are sorted to ensure optimal functioning of the recycled vesicles.

However, it was not clear whether this extra step was relevant for vesicle recycling in brain cells. Various studies seemed to demonstrate that it was in fact missing in brain cells.

Skywalker regulates communication between brain cells

Patrik Verstreken and his colleagues have now discovered an enzyme, christened Skywalker, which regulates this extra step. The VIB researchers tested fr
'/>"/>

Contact: Joris Gansemans
joris.gansemans@vib.be
329-244-6611
VIB (the Flanders Institute for Biotechnology)
Source:Eurekalert

Page: 1 2

Related biology news :

1. Like products, plants wait for optimal configuration before market success
2. April grafting optimal for Fraser fir
3. Study uncovers optimal ecology of bioinsecticide
4. Latest analysis confirms suboptimal vitamin D levels in millions of US children
5. NIMBioS hosts tutorial on optimal control and optimization for biologists
6. Optimal dose of vitamin E maximizes benefits, minimizes risk
7. Science reporter wins ASM Public Communications Award
8. Communication engages complex brain circuitry and processes
9. Brain cell communication: Why its so fast
10. Metcalf Institute wins NSF grant to help journalism and communication of oil spill research
11. Teaching communication and information literacy skills
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/17/2014)... 2014 Research and Markets ( http://www.researchandmarkets.com/research/9zq33j/global_chemical ) ... Sensor Market 2015-2019" report to their offering. ... major trend upcoming in this market is the increasing ... help in recording of patient data for quick and ...
(Date:12/11/2014)... and Markets , http://photos.prnewswire.com/prnh/20130307/600769 ... the addition of the "Biometrics Market in the ... One major trend emerging in this market is ... is important to upgrade biometric solutions to the latest ...
(Date:12/11/2014)... Minn. , Dec. 10, 2014  Data Sciences ... monitoring, has released a new series of digital ... preclinical toxicology researchers. M series, part of the ... collect the best possible physiologic data when incorporating ...
Breaking Biology News(10 mins):Global Chemical Sensor Market 2015-2019: Key Vendors are Abbott Laboratories, Bayer, Hoffmann La-Roche, Johnson & Johnson, NGK Spark Plugs and Robert Bosch 2Biometrics Market in the APAC Region 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2New telemetry implants expected to change how large animal toxicology studies are conducted 2
... Associate Professor Paul Blowers of the University of Arizona ... Arizona Professor of the Year, recognized for commitment to ... of Teaching and the Council for Advancement and Support ... the award on Nov. 17 in Washington, D.C. ...
... beauty of science often is contained in elegant formulas ... fortunately, that beauty also is manifest in enticing images ... also provide important scientific insights into the complex flow ... Every year, the American Physical Society,s (APS) Division ...
... recent report in Cancer Discovery , a journal ... a new treatment may be on the horizon for ... disease. Mark Rubin, M.D., professor of pathology and ... fewer than 2 percent of men with prostate cancer ...
Cached Biology News:Arizona Engineering associate professor earns national recognition 2
(Date:1/22/2015)... GEA Niro Soavi the leader in ... the PandaPLUS 2000, which is ideal for new applications ... cell disruption . This compact laboratory homogenizer is the ... food, food additives and ingredients as well as for ...
(Date:1/22/2015)... Cambridge Semantics, the leading provider of smart data ... was a record-breaking year across the board for the company. ... Data Platform and our Smart Data solutions, our customers were ... which led to record growth for the company in 2014,” ...
(Date:1/22/2015)... Protocol Networks brings independent technology consulting to the ... consultants, Protocol Networks has recently announced its expansion into ... his company has attracted several clients in The Constitution ... as others. With the success of these engagements, Rogers ...
(Date:1/22/2015)... 22, 2015 Pipette.com has added the ... their comprehensive portfolio of Eppendorf products. , The Eppendorf ... a Centrifuge 5424/5424 R and receive the following:, ... Research plus or Eppendorf Reference 2 , ...
Breaking Biology Technology:GEA Niro Soavi Announces the PandaPLUS 2000 Homogenizer for Processing New Applications for Nanoemulsions and Cell Disruption 2Cambridge Semantics Announces Record Results for 2014 2Protocol Networks Brings Independent Technology Consulting to the Constitution State 2Eppendorf Announces Promotional Bundle Which Includes: Eppendorf Centrifuge 5424, 3-Pack of Pipettes, and Tips - Available Now at Pipette.com 2
... Feb. 5 Memory Pharmaceuticals,Corp. (Nasdaq: MEMY ... Chief,Executive Officer, will provide a company update at ... Tuesday, February 12, 2008 at 10:15 a.m. ET ... Interested parties may access the live webcast of ...
... 5 ViroPharma Incorporated,(Nasdaq: VPHM ) today ... operating officer of ViroPharma, will present at the ... on Monday, February 11, 2008. The,conference is being ... ViroPharma,s presentation will be webcast live for investors ...
... Feb. 5 Physicians Reference,Laboratory ("PRL") announced today that ... to date. Under the marketed,name COMPLeTe Care HPV, the ... high risk types of HPV which can lead to,cervical ... common form of female,cancer with an incidence of over ...
Cached Biology Technology:Physicians Reference Laboratory Announces New Diagnostic for Women's Health 2
Mouse monoclonal [LPL4A.1] to Plastin L ( Abpromise for all tested applications). SwissProtID: P13796...
Anti-Cullin-1 Host: rabbit polyclonal Species Reactivity: human, mouse Applications: IHC(P), WB, IP Storage: 4C...
mCD-1 10 transcription reactions...
Request Info...
Biology Products: