Navigation Links
Skull shape risk factors could help in the welfare of toy dog breeds
Date:8/6/2014

New research has identified two significant risk factors associated with painful neurological diseases in the skull shape of the Cavalier King Charles Spaniel (CKCS). The findings could help in tackling these conditions in toy dog breeds and could be used in breeding guidelines.

The study conducted by undergraduate student, Thomas Mitchell, from the University of Bristol's School of Veterinary Sciences, and supervised by Dr Clare Rusbridge, is published online in the journal Canine Genetics and Epidemiology.

Syringomyelia (SM) is a painful condition in dogs and is more common in toy breeds. It involves the formation of fluid-filled cavities, known as syrinxes, in the spinal cord. This condition affects many popular toy breeds, including the CKCS and Chihuahua. In these toy breeds, SM is usually secondary to a specific malformation of the skull called Chiari-like Malformation, CM for short.

There has been debate as to whether head shape of these dogs is related to CM/SM, especially as some humans have similar characteristic facial and skull shapes, and what this may be. Identifying a head shape in dogs that is associated with these diseases would allow for selection away from these conditions and could be used to further breeding guidelines. Dogs were measured in several countries using a standardised "bony landmark" measuring system and photo analysis by trained researchers.

The researchers found two significant risk factors associated with CM/SM in the skull shape of the CKCS. These were the extent of the broadness of the top of skull relative to its length, also known as brachycephaly, and the distribution of doming of the skull. The study suggests that brachycephaly, with resulting doming towards the front of the head, is associated with CM/SM.

Thomas Mitchell said: "Dog breeders are very experienced at selecting for a certain conformation or appearance in dogs. Our findings may allow breeders to select away from the condition over fewer generations by choosing appropriate matings and offspring to continue breeding programmes. The identification of an appearance that might protect against developing the disease is a significant step forward in tackling this painful condition.

"The study also provides guidance to breed clubs, breeders and judges that have a responsibility to avoid obvious conditions or exaggerations which would be harmful in any way to the health, welfare or soundness of the breed. It will also provide vets with verified advice to provide to breeders outside the show ring and to occasional hobbyists."


'/>"/>
Contact: Joanne Fryer
joanne.fryer@bristol.ac.uk
44-011-733-17276
University of Bristol
Source:Eurekalert

Related biology news :

1. Skulls of red and giant pandas provide insight into coexistence
2. New study changes conceptions about the determinants of skull development and form
3. Ardi skull reveals links to human lineage
4. Fresh analysis of dinosaur skulls by penn researchers finds 3 species are 1
5. International team discovers likely basis of birth defect causing premature skull closure in infants
6. Old skull bone rediscovered
7. Key adjustment enables parasite shape-shifting
8. SLU scientists hit delete: Removing regions of shape-shifting protein explains how blood clots
9. New horned dinosaur reveals unique wing-shaped headgear
10. Did violence shape our faces?
11. Sneaky bacteria change key proteins shape to escape detection
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/20/2016)... , June 20, 2016 Securus ... justice technology solutions for public safety, investigation, corrections ... the prisons involved, it has secured the final ... (DOC) facilities for Managed Access Systems (MAS) installed. ... additional facilities to be installed by October, 2016. ...
(Date:6/9/2016)... 2016  Perkotek an innovation leader in attendance control systems is proud to announce ... for employers to make sure the right employees are actually signing in, and to ... ... ... ...
(Date:6/3/2016)... 3, 2016 Das ... Nepal hat ein 44 ... geprägter Kennzeichen, einschließlich Personalisierung, Registrierung und IT-Infrastruktur, ... Produktion und Implementierung von Identitätsmanagementlösungen. Zahlreiche renommierte ... Januar teilgenommen, aber Decatur wurde als konformste ...
Breaking Biology News(10 mins):
(Date:6/24/2016)... , June 24, 2016 Epic Sciences ... detects cancers susceptible to PARP inhibitors by targeting ... cells (CTCs). The new test has already been ... in multiple cancer types. Over 230 ... damage response pathways, including PARP, ATM, ATR, DNA-PK ...
(Date:6/24/2016)... ... June 24, 2016 , ... Researchers at the Universita ... miRNAs in people with peritoneal or pleural mesothelioma. Their findings are the subject of ... now. , Diagnostic biomarkers are signposts in the blood, lung fluid or tissue ...
(Date:6/23/2016)... ... June 23, 2016 , ... ... to announce the launch of their brand, UP4™ Probiotics, into Target stores nationwide. ... years, is proud to add Target to its list of well-respected retailers. This ...
(Date:6/23/2016)... TORONTO , June 23, 2016 /PRNewswire/ - ... Ontario biotechnology company, Propellon ... the development and commercialization of a portfolio of ... cancers. Epigenetic targets such as WDR5 represent an ... contribute significantly in precision medicine for cancer patients. ...
Breaking Biology Technology: