Navigation Links
Skin cancer study uncovers new tumor suppressor gene
Date:3/29/2009

ly serves as a tumor suppressor gene in melanoma. Consequently, in the estimated 6 percent of melanoma patients whose tumors harbor a mutated MMP-8 gene or related tumor suppressor(s), it may not be wise to block all MMPs. The study suggests that a better approach may be to look for drugs that restore or increase MMP-8 function or for drugs that block only those MMPs that are truly oncogenes.

"This research is an illustrative proof of concept that shows the value of genomic strategies for understanding cancer and possible therapies," said NHGRI Scientific Director Eric Green, M.D., Ph.D. "It is gratifying to see that genomic technologies are guiding scientific discovery, advancing cancer research, especially melanoma research."

Melanoma is the most serious form of skin cancer. In the United States and many other nations, melanoma is becoming more common every year. A major cause is thought to be overexposure to the sun. The ultraviolet radiation in sunlight can damage DNA and lead to cancer-causing genetic changes within skin cells.

MMP enzymes help the body to break down and recycle proteins, playing a crucial role in the process of remodeling skin after sunburns, cuts or other injuries. The MMP gene family has been associated with tumor growth in a variety of cancers, including breast, colon and melanoma.

To explore the role of MMP genes in melanoma, the NHGRI researchers studied a bank of tumor and blood samples collected from 79 patients with aggressive melanoma by collaborator Steven Rosenberg, M.D., Ph.D., chief of surgery at the National Cancer Institute (NCI). Specifically, they compared the sequence of MMP genes in tumors and normal DNA from the same patients, looking for mutations in all 23 members of the MMP gene family.

The researchers identified 28 different mutations in eight MMP genes in the melanoma tumors studied. These mutations were found to be distributed in different frequencies and patterns among th
'/>"/>

Contact: Raymond MacDougall
macdougallr@mail.nih.gov
301-402-0911
NIH/National Human Genome Research Institute
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Getting down to cancer basics
2. Mayo Clinic researchers discover and manipulate molecular interplay that moves cancer cells
3. Scripps scientists find structure of a protein that makes cancer cells resistant to chemotherapy
4. New drug agent knocks out multiple enzymes in cancer pathway
5. Molecular fingerprints point the way to earlier cancer diagnosis and more targeted treatment
6. Lombardi research: Monoclonal antibodies primed to become potent immune weapons against cancer
7. Research yields potential target for cancer, wound healing and fibrosis
8. Lab-on-a-chip homes in on how cancer cells break free
9. TGens Dr. Von Hoff wins award for cancer research
10. Researchers identify genetic markers for aggressive head and neck cancer
11. Cancer: Another step towards medication
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/29/2014)... stretch them, twist them, fold them: modern materials that ... potential, whether as artificial skin or electronic paper. , ... a challenge but a new way of working with ... a game-changer. , Previous success in the field ... use of precious gold and silver nanowires. , ...
(Date:8/28/2014)... of marine protected areas is needed to protect fish ... investigators from the Wildlife Conservation Society and other organizations, ... the largest numbers of species, often at the expense ... functions. , Many vital ecological functions of ... are food for millions of people. This study ...
(Date:8/28/2014)... Researchers at the University of Minnesota have developed ... to be used for muscle regeneration research as well ... FSHD. , The research is published in the current ... There is no treatment for FSHD, which is thought ... muscular dystrophy. FSHD is an unusual genetic disorder because, ...
Breaking Biology News(10 mins):Copper shines as flexible conductor 2Study finds marine protected areas inadequate for protecting fish and ocean ecology 2UMN researchers find animal model for understudied type of muscular dystrophy 2
... BLOOMINGTON, Ind. -- Two recently diverged populations of a ... contribute to the reproductive isolation that accompanies the origin ... of organic compounds present in the preen oils of ... Ecology . "There,s so much we don,t know ...
... Age and gender play a major role in how ... 20-to-64-year-olds. Published in the journal Psychophysiology , the investigation ... the Montreal Heart Institute in collaboration with colleagues from the ... findings suggest that women who are more defensive are at ...
... University of Western Ontario finds the sauces you use when ... benefits. The research, led by Western biology and psychology ... than just tasty sauces they can also provide a ... Mark Bernards and Christopher Guglielmo in Western,s department of biology. ...
Cached Biology News:Could smell play a role in the origin of new bird species? 2Could smell play a role in the origin of new bird species? 3Men and women respond differently to stress 2Spice up your health this barbecue season 2
(Date:8/28/2014)... A new research platform uses a laser ... structures undergoing stress and heating, an approach ... for microelectronics and batteries., This new technique, ... how heating and the surface stress of ... have discussed the merits of surface-stress influence ...
(Date:8/28/2014)... --  SunTrust Robinson Humphrey (STRH) today announced ... equity research team in biotechnology and oilfield services.  ... research demonstrates our commitment to providing our valued ... investment decision making," said Biff Woodruff , ... make significant investments in differentiated content at a ...
(Date:8/28/2014)... Woodstock, Vt. (PRWEB) August 28, 2014 ... microbiology testing around the world is available from ... industrial diagnostics companies. “ Industrial Microbiology Market Review, ... the Industrial Market ” (IMMR—4) tracks and compares ... in in North America, Europe and Asia, and ...
(Date:8/27/2014)... Lake City, Utah (PRWEB) August 27, 2014 ... construction that will expand its current Salt Lake City ... currently underway outside of Utah to ultimately create 1,000 ... next 20 years. , “Utah is home to ... of whom can be credited with Varian’s success in ...
Breaking Biology Technology:New analytical technology reveals 'nanomechanical' surface traits 2New analytical technology reveals 'nanomechanical' surface traits 3SunTrust Robinson Humphrey Expands Equity Research in Healthcare and Energy 2SunTrust Robinson Humphrey Expands Equity Research in Healthcare and Energy 32 Billion Industrial Microbiology Tests Conducted for Product Quality and Safety Worldwide 22 Billion Industrial Microbiology Tests Conducted for Product Quality and Safety Worldwide 3Varian Medical Systems Groundbreaking on Facility Expansion Triggers Influx of New Jobs to Salt Lake 2Varian Medical Systems Groundbreaking on Facility Expansion Triggers Influx of New Jobs to Salt Lake 3
... LPBP Inc. (LPBP) - At the request of,the ... of,the President and Chief Executive Officer and of ... of its interim filings for the quarters,ended January ... were,previously filed. The re-filing of these Certificates is ...
... Profitability, HARBIN, China, Aug. 15 /Xinhua-PRNewswire-FirstCall/ -- ... Board: CKGT), a,vertically integrated grower, developer, manufacturer and ... China, announced today record,second quarter results for the ... of $5.0 million, a 34.9% increase compared to ...
... 15 Catalyst,Pharmaceutical Partners, Inc. (Nasdaq: CPRX ... and six months ended June 30, 2008., ... program for,CPP-109," stated Patrick J. McEnany, Catalyst,s Chief ... dosing subjects in our U.S.,Phase II clinical trials ...
Cached Biology Technology:China Kangtai Cactus Biotech Announces Record Second Quarter Results 2China Kangtai Cactus Biotech Announces Record Second Quarter Results 3Catalyst Pharmaceutical Partners Reports Second Quarter 2008 Financial Results 2Catalyst Pharmaceutical Partners Reports Second Quarter 2008 Financial Results 3Catalyst Pharmaceutical Partners Reports Second Quarter 2008 Financial Results 4Catalyst Pharmaceutical Partners Reports Second Quarter 2008 Financial Results 5
... GenomePlex Single Cell Whole Genome Amplification ... on random fragmentation of genomic DNA ... fragments to PCR-amplifiable library molecules flanked ... achieved by PCR amplification of the ...
...
From formula-fed bovine calves Sterile, Cell culture tested...
Collected at a certified USDA establishment located within the United States. All final processing is done by Quad Five employees....
Biology Products: