Navigation Links
Skewered pumpkins
Date:3/7/2008

This release is available in German.

We encounter valves every day, whether in the water faucet, the carburetor in our car, or our bicycle tire tube. Valves are also present in the world of nanotechnology. A team of researchers headed by J. Fraser Stoddart and Jeffrey I. Zink at the University of California, Los Angeles, has now developed a new nanovalve. In the journal Angewandte Chemie, the scientists reveal what is special about it: In contrast to prior versions, which only function in organic solvents, this valve operates in an aqueous environment and under physiological conditionsprerequisites for any application as a gate for nanoscopic drug-transport agents, which need to set their cargo free at the right place and time.

In order for pharmaceuticals to affect only the target diseased organ, suitable nanopackaging is required to bring the drug to the target area and release it only there. One example of a good nanoscopic packaging agent is a tiny sphere of porous silica. Its pores can be filled with the drug and closed with tiny controllable valves.

The scientists attached stem-shaped molecules onto the surface of the porous spheres and filled the pores with guest molecules. At neutral to acidic pH values, they stacked cucurbituril molecules onto these stems. Cucurbituril is a fat, ring-shaped molecule reminiscent of a pumpkin that has both ends hollowed out. The resulting supramolecular structure, which resembles a skewered pumpkin and is known to chemists as a pseudorotaxane, blocks the pores, so that the guest molecules cannot exit. The nanovalve is closed.

If the pH value is raised into the basic range, however, the interaction between the pumpkins and the skewers is weakened, and the pumpkins come off, opening the pores. Now the valves are open and the guest molecules can exit.

At this point the molecular details of the individual components still need to be tweaked. The goal: very small differences in pH values between healthy and diseased tissue should be sufficient to switch the valves and release the drug only in diseased cells.


'/>"/>

Contact: Jeffrey I. Zink
zink@chem.ucla.edu
310-825-1001
Wiley-Blackwell
Source:Eurekalert  

Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Skewered pumpkins
(Date:4/19/2016)... , UAE, April 20, 2016 ... be implemented as a compact web-based "all-in-one" system solution ... the biometric fingerprint reader or the door interface with ... of modern access control systems. The minimal dimensions of ... ID readers into the building installations offer considerable freedom ...
(Date:4/15/2016)... DUBLIN , April 15, 2016 ... of the,  "Global Gait Biometrics Market 2016-2020,"  report ... http://photos.prnewswire.com/prnh/20160330/349511LOGO ) , ,The global gait ... CAGR of 13.98% during the period 2016-2020. ... movement angles, which can be used to compute ...
(Date:4/13/2016)... CHICAGO , April 13, 2016  IMPOWER physicians ... are setting a new clinical standard in telehealth ... By leveraging the higi platform, IMPOWER patients can ... weight, pulse and body mass index, and, when they ... quick and convenient visit to a local retail location ...
Breaking Biology News(10 mins):
(Date:4/26/2016)... ... 26, 2016 , ... This unique "Fertility Happy Hour" event will be held ... to get the lowdown on female fertility and the reproductive technologies that are empowering ... of Boston IVF - The Arizona Center, will give a short presentation and ...
(Date:4/26/2016)... ... April 26, 2016 , ... Seattle based non-profit, The Institute ... 1Plus12 Corporation. The grant will be used to further the scientific research goals ... website http://www.ivsci.org , In accounting the grant to the IVS, Mr. ...
(Date:4/26/2016)... ... April 26, 2016 , ... uBiome, the leading microbial genomics ... on the company’s Advisory Board. Prior to co-founding Plum in 2007, Neil Grimmer was ... at IDEO. , A renowned, innovative designer of ideas, products, and brands, Grimmer has ...
(Date:4/26/2016)... 2016 genae, a Contract Research ... announced today the appointment of Prof. Dr. Jörn Balzer ... responsibilities will include all clinical, safety and risk management ... privileged and honored with the acceptance of Prof. Balzer ... CEO at genae. "Prof. Balzer,s impressive and extensive background ...
Breaking Biology Technology: