Navigation Links
Site used by sodium to control sensitivity of certain potassium ion channels
Date:9/18/2008

RICHMOND, Va. (Sept. 18, 2008) Virginia Commonwealth University School of Medicine researchers have uncovered how sodium is able to control specific potassium ion channels in cells, according to new study findings published online this week in Nature Chemical Biology.

These findings, published Sept. 14, may help researchers gain a greater understanding of the mechanisms involved in ion channel gating and may one day set the stage for new approaches in drug design.

Intracellular-sodium is known to control the opening and closing of certain potassium channels. Using a computational-experimental approach, researchers examined the interaction between sodium and a group of potassium channels known as Kir channel proteins. The team had previously shown that Kir3 channels are sensitive to sodium, but had not shown how sodium is coordinated by specific amino acids found in several Kir channel proteins.

"We have a fairly good molecular understanding of how the sodium ions are coordinated and we have a compelling hypothesis of how the coordination of sodium may be affecting this particular type of potassium ion channel to open it," said Diomedes Logothetis, Ph.D., an internationally recognized leader in the study of ion channels and chair of the VCU School of Medicine's Department of Physiology and Biophysics.

According to Logothetis, ion channel proteins are found in the plasma membrane of cells and provide a path for hydrated cations such as calcium, potassium or sodium to pass through the membrane and travel in and out of the cell. Generally, hydrated ions do not travel through the lypophillic, or fat-based, plasma membrane because they are surrounded with water and require a pathway to travel from one side of the membrane to the other.

"By applying the knowledge of the sodium coordination site, we identified the Kir5.1 channel that was not previously suspected to be sodium-sensitive. By examining in which cells t
'/>"/>

Contact: Sathy Achia Abraham
sbachia@vcu.edu
804-827-0890
Virginia Commonwealth University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Biologists identify genes controlling rhythmic plant growth
2. Biological clock genes control plant growth
3. JDRF-funded clinical trial demonstrates continuous glucose monitoring improves blood sugar control
4. Biocontrol insect exacerbates invasive weed
5. Study shows more genes are controlled by biological clocks
6. Iowa State University researcher shows proteins have controlled motions
7. Scientists to assess Beijing Olympics air pollution control efforts
8. Scripps scientists will assess Beijing Olympics air pollution control efforts
9. People with heart disease still have trouble controlling blood lipid levels
10. Caltech researchers find dual-use sexual attraction and population-control chemicals in nematodes
11. Researchers discover cells quality control mechanism
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/18/2014)... - Washington State University researchers have developed a unique ... power waste cleanup in rural areas. , The ... an inexpensive and quick way to clean up waste ... while reducing pollution. , Professor Haluk Beyenal and ... Engineering and Architecture discuss the system in the online ...
(Date:9/18/2014)... novel robotic system that can operate inside the bore ... part of a biomedical research partnership program at Brigham ... determining if the robot, in conjunction with real-time MRI ... less costly, and less discomforting for the patient. The ... cancer therapies with greater precision. , Developed by a ...
(Date:9/18/2014)... language is unique to humans. "The genetic changes that ... evolution to make this possible are largely unknown, but ... says Wolfgang Enard, Professor of Anthropology and Human Biology ... biological basis of language Enard has now taken an ... undertaken in collaboration with scientists at several universities, including ...
Breaking Biology News(10 mins):Researchers develop unique waste cleanup for rural areas 2Trial begins for MRI-compatible robot designed to improve accuracy of prostate biopsies 2Trial begins for MRI-compatible robot designed to improve accuracy of prostate biopsies 3Trial begins for MRI-compatible robot designed to improve accuracy of prostate biopsies 4Trial begins for MRI-compatible robot designed to improve accuracy of prostate biopsies 5Language evolution: Quicker on the uptake 2Language evolution: Quicker on the uptake 3
... Calif., May 9, 2012 Human cells are thought to ... that help determine which genes are turned on or off ... normal cellular function, but they can also contribute to human ... promote cell survival. But to better understand how miRNAs influence ...
... to understand how the aging process affects the brain ... older adults. "Everybody ages differently. By looking at ... health, we begin to understand that preventable factors may ... University psychology doctoral student Andrew Bender, lead author of ...
... May 9, 2012 (Bronx, NY) Researchers at ... University have discovered a molecule that inhibits the action ... in the growth, maintenance and repair of reproductive tissues ... The molecule, discovered in animal studies, could lead to ...
Cached Biology News:It's a trap! New laboratory technique captures microRNA targets 2WSU researchers say genes and vascular risk modify effects of aging on brain and cognition 2WSU researchers say genes and vascular risk modify effects of aging on brain and cognition 3Molecule found that inhibits estrogen, key risk factor for endometrial and breast cancers 2
(Date:9/18/2014)... , Sept. 18, 2014 About POCT ... is performed outside a clinical laboratory. It helps ... administrating appropriate treatments and medication. POCT is gaining ... of lifestyle diseases such as diabetes, heart disease, ... POCT devices are standardized to minimize errors during ...
(Date:9/18/2014)... Bryan-College Station, Texas (PRWEB) September 18, 2014 ... University System Chancellor John Sharp, Texas A&M Health ... from the U.S. Department of Health and Human ... GSK today dedicated a national pandemic influenza vaccine ... will serve as an anchor for the Texas ...
(Date:9/18/2014)... , Sept. 18, 2014 Research ... "Global Companion Diagnostics (Polymerase Chain Reaction, In-situ hybridization, ... report to their offering. The global ... CAGR of 22.7% from 2014 to 2019. Factors such ... growing adoption of companion diagnostics by the pharmaceutical industry, ...
(Date:9/18/2014)... - Oncothyreon Inc. (NASDAQ: ONTY ) today ... underwritten offerings of 10,000,000 shares of its Common Stock ... share, for expected gross proceeds of $20 million and ... at a price to the public of $2,000.00 per ... share of Series A Convertible Preferred Stock is non-voting ...
Breaking Biology Technology:POCT Market in China 2014-2018 2Texas A&M Dedicates National Pandemic Influenza Vaccine Manufacturing Facility, on Track for 2016 Start-Up Phase 2Texas A&M Dedicates National Pandemic Influenza Vaccine Manufacturing Facility, on Track for 2016 Start-Up Phase 3Texas A&M Dedicates National Pandemic Influenza Vaccine Manufacturing Facility, on Track for 2016 Start-Up Phase 4Global Companion Diagnostics (Polymerase Chain Reaction, In-situ hybridization, Immunohistochemistry) Market - Trends & Forecasts to 2019 2Global Companion Diagnostics (Polymerase Chain Reaction, In-situ hybridization, Immunohistochemistry) Market - Trends & Forecasts to 2019 3Oncothyreon Prices $40 Million Concurrent Public Offerings of Common Stock and Preferred Stock 2Oncothyreon Prices $40 Million Concurrent Public Offerings of Common Stock and Preferred Stock 3
... recruiting tech talent and investors to state, ... Enterprise,Corporation (KTEC) announced today a "Come Home to ... technology professionals,and investors to Kansas. Partners in this ... Bioscience Authority, the Kansas,Bioscience Organization and the KTEC ...
... Hologic, Inc.,(Nasdaq: HOLX ), a diversified ... and interventional devices dedicated to,serving the healthcare needs ... quarter fiscal 2008 operating results on Thursday, January ... the release, management will,host a conference call on ...
... and Webcast Scheduled for Tuesday, February 5, SAN ... ) announced today that the Company will report its ... market closes,on Tuesday, February 5, 2008. Neurocrine will then ... financial results and provide a Company,update Tuesday afternoon, February ...
Cached Biology Technology:'Come Home to Kansas' Announced by KTEC 2Hologic, Inc. to Release First Quarter Fiscal 2008 Operating Results Thursday, January 31st Before Market Opens 2Neurocrine Biosciences Announces Conference Call and Webcast to Present Fourth Quarter and Year End 2007 Financial Results 2
The Programmable MP-5000P-F Power Supply can be applied for any Microfluidic application....
... Programmable Power Supply are high-performance, easy ... virtually any application from high voltage ... is unique in offering both graphic ... Programmable Power Supply is completely programmable ...
Coating : Poly-D-Lysine ,Surface : ECM/attachment factors ,Surface area : 9.6 cm2 ,Dim nominal : 35 mm x 10 mm ,Vol working : 2.5-3.0 ml ...
BD BioCoat Collagen IV 35 mm Culture Dishes, tissue-culture treated polystyrene with a uniform application of mouse collagen type IV....
Biology Products: