Navigation Links
Sinusitis linked to microbial diversity
Date:9/12/2012

A common bacteria ever-present on the human skin and previously considered harmless, may, in fact, be the culprit behind chronic sinusitis, a painful, recurring swelling of the sinuses that strikes more than one in ten Americans each year, according to a study by scientists at the University of California, San Francisco.

The team reports this week in the journal Science Translational Medicine that sinusitis may be linked to the loss of normal microbial diversity within the sinuses following an infection and the subsequent colonization of the sinuses by the culprit bacterium, which is called Corynebacterium tuberculostearicum.

In their study, the researchers compared the microbial communities in samples from the sinuses of 10 patients with sinusitis and from 10 healthy people, and showed that the sinusitis patients lacked a slew of bacteria that were present in the healthy individuals. The patients also had large increases in the amount of Corynebacterium tuberculostearicum in their sinuses, which are located in the forehead, cheeks and eyes.

The team also identified a common bacterium found within the sinuses of healthy people called Lactobacillus sakei that seems to help the body naturally ward off sinusitis. In laboratory experiments, inoculating mice with this one bacterium defended them against the condition.

"Presumably these are sinus-protective species," said Susan Lynch, PhD, an associate professor of medicine and director of the Colitis and Crohn's Disease Microbiome Research Core at UCSF.

What it all suggests, she added, is that the sinuses are home to a diverse "microbiome" that includes protective bacteria. These "microbial shields" are lost during chronic sinusitis, she said, and restoring the natural microbial ecology may be a way of mitigating this common condition.

A Painful, Costly Condition

Sinuses are air-filled cavities in the front of the
'/>"/>

Contact: Jason Socrates Bardi
jason.bardi@ucsf.edu
415-502-6397
University of California - San Francisco
Source:Eurekalert  

Page: 1 2

Related biology news :

1. BUSM/VA Boston Healthcare System investigators identify new gene linked to PTSD
2. Protein involved in DNA replication, centrosome regulation linked to dwarfism, small brain size
3. Gene mutations linked to most cases of rare disorder -- Alternating Hemoplegia of Childhood
4. BGI reports the latest finding on NMNAT1 mutations linked to Leber congenital amaurosis
5. New gene mutations linked to ALS and nerve cell growth dysfunction
6. Viruses linked to algae that control coral health
7. Myelodysplastic syndromes (MDS) linked to abnormal stem cells
8. Low vitamin D levels linked to weight gain in some older women
9. Mild thyroid dysfunction in early pregnancy linked to serious complications
10. Research identifies specific bacteria linked to indoor water-damage and mold
11. Childhood virus infection linked to prolonged seizures with fever
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Sinusitis linked to microbial diversity
(Date:8/27/2014)... Outstanding basic research, a growing focus on translating ... care have earned the Herbert Irving Comprehensive Cancer ... and NewYork-Presbyterian Hospital an $18 million, five-year Cancer ... (NCI). The grant renews the center,s status as ... in New York City and one of only ...
(Date:8/27/2014)... studies have shown that excessive iron is ... disease. Previous studies from Chunyan Guo and ... have shown that baicalin prevented iron accumulation ... transporter 1 expression, and increased ferroportin 1 ... Parkinson,s disease rats. However, the relationship between ...
(Date:8/27/2014)... ago the Happy Camp Complex of fires had consumed ... complex had consumed 35,530 as of eight hours ago. ... Happy Camp Ranger District of the Klamath National Forest ... 11, 2014. All but three of those fires are ... of contained fires and their size at containment: Delta, ...
Breaking Biology News(10 mins):Herbert Irving Comprehensive Cancer Center awarded $18 million grant 2Herbert Irving Comprehensive Cancer Center awarded $18 million grant 3Herbert Irving Comprehensive Cancer Center awarded $18 million grant 4Happy Camp and July Fire Complexes in California 2
... being able to predict the risk of disease or response ... a study by scientists at Washington University School of Medicine ... alone only tell part of the story. That,s because ... to predict, even in simple organisms like single-celled yeast, their ...
... Virginia Commonwealth University Massey Cancer Center led by Charles ... Biology, discovered a previously unknown mechanism in non-small cell ... to maintain and grow tumors. Narrowing in on this ... effective therapies for NSCLC and other cancers. ...
... 2010, Seoul, S. Korea Institut Pasteur Korea (IP-K) ... of Toulouse, France to continue research on the identification ... up in the fall of 2009, illustrates the value ... platform will be used to pinpoint active, non-toxic agents ...
Cached Biology News:The gene-environment enigma 2The gene-environment enigma 3VCU Massey discovery could lead to breakthrough for non-small cell lung cancer 2
(Date:8/27/2014)... Research and Markets  has announced ... (Biodegradable Polymer, Food & Beverage, Personal Care & ... report to their offering. Lactic ... asymmetrical carbon atom. The main applications of lactic ... beverage, personal care product, and pharmaceutical industries. ...
(Date:8/27/2014)... 2014  Lisa Kulik saw fireworks for the first ... thanks to a groundbreaking retinal implant co-invented by ... at the University of Southern California (USC) Eye Institute. ... Ariz. resident who has retinitis pigmentosa, a ... On June 2, she became the first person west ...
(Date:8/27/2014)... 27, 2014  A novel biomarker for rheumatoid ... better identify early-stage disease, when treatment can often ... a new study in The Journal of Rheumatology. ... DGX ) and other institutions found that ... conventional antibody-serum testing, including rheumatoid factor (RF) and ...
(Date:8/27/2014)... (PRWEB) August 27, 2014 “We are ... technology vendors,” said Ven Thangaraj, CEO of Radiant Sage. ... that are taking the imaging corelab market to a ... corelabs and research organizations to efficiently and effectively manage ... the data to be analyzed and read by trained ...
Breaking Biology Technology:Global Lactic Acid (Biodegradable Polymer, Food & Beverage, Personal Care & Pharmaceutical) Market - Trends & Forecasts to 2019 2USC Eye Institute ophthalmologists implant first FDA-approved Argus II retinal prosthesis in western United States 2USC Eye Institute ophthalmologists implant first FDA-approved Argus II retinal prosthesis in western United States 3USC Eye Institute ophthalmologists implant first FDA-approved Argus II retinal prosthesis in western United States 4USC Eye Institute ophthalmologists implant first FDA-approved Argus II retinal prosthesis in western United States 5Novel Biomarker Detects Early Rheumatoid Arthritis Better than Conventional Methods Alone, According to Journal of Rheumatology Study 2Novel Biomarker Detects Early Rheumatoid Arthritis Better than Conventional Methods Alone, According to Journal of Rheumatology Study 3Novel Biomarker Detects Early Rheumatoid Arthritis Better than Conventional Methods Alone, According to Journal of Rheumatology Study 4Radiant Sage Named to CIOReview List of 100 Most Promising Technology Companies 2
... Monitorforhire.com, the,fastest source for hiring independent ... The company has added a mobile portal, ... to work requests via,PDA or cell phone ... president of monitorforhire.com says that adding the,capability ...
... in San Francisco on Wednesday, October ... ... 2 Favrille, Inc. (Nasdaq:,FVRL), a biopharmaceutical company developing patient-specific, active,immunotherapies ... Officer, will present at the Biotechnology,Industry Organization (BIO) InvestorForum at 10:15 ...
... Sciences, a Roche,company, and Perlegen Sciences, Inc., today ... in hundreds of DNA samples,collected by Perlegen from ... of drug. The goal of the collaboration will ... identified and,validated to create a clinical test that ...
Cached Biology Technology:New Pharmacogenomic Approach: 454 Life Sciences and Perlegen to Collaborate in Drug Response Sequencing Study 2New Pharmacogenomic Approach: 454 Life Sciences and Perlegen to Collaborate in Drug Response Sequencing Study 3
...
Contains L-glutamine....
... Resolution - Efficiently separates ... to 1000 bp. It ... PCR fragments, small DNA ... enzyme digestion, and double-stranded ...
...
Biology Products: