Navigation Links
Single protein promotes resistance to widely used anti-estrogen drugs
Date:7/1/2012

WASHINGTON -- Researchers at Georgetown Lombardi Comprehensive Cancer Center have uncovered a single molecule they say is a major determinant of resistance to anti-estrogen therapy used to treat or prevent breast cancer in high-risk women.

In the July 1 issue of Cancer Research, the scientists say glucose-regulated protein 78 (GRP78), activated as breast cells undergo stress induced by the agents tamoxifen and fulvestrant, turns off apoptosis, a cell death response, and turns on autophagy. In autophagy, the cell "eats" and digests components within the cell body that have been harmed by the drugs, thus providing a blast of nutrients needed to maintain life.

The finding suggests that a novel agent that inhibits GRP78 might provide a solution for the tens of thousands of women who develop resistance to anti-estrogen drugs. While more than 70 percent of breast cancers express estrogen receptors that fuel growth of cancer, about one-third of these cases fail to be cured by therapies that target this receptor.

"Since GRP78 plays such an important role in drug resistance, it would be of great benefit to develop agents that target this protein," says the study's lead author, Katherine Cook, Ph.D., a postdoctoral investigator in the lab of Robert Clarke, Ph.D., D.Sc., professor of oncology and Dean for Research at Georgetown University Medical Center. Clarke is the study's senior author.

She adds that several GRP78 inhibitors have already been developed and are already being tested, but not yet at the level of human clinical trials.

The study is not only the first to show that GRP78 is a regulator of resistance to tamoxifen and fulvestrant, it is also the first to reveal the mechanism by which GRP78 directly controls autophagy, says Clarke.

"Why estrogen-receptor positive breast tumors fail to respond, or respond initially and progress upon acquiring resistance to these agents, has been largely unknown, " he
'/>"/>

Contact: Karen Mallet
km463@georgetown.edu
Georgetown University Medical Center
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Columbia Engineering and Penn researchers increase speed of single-molecule measurements
2. Researchers reveal how a single gene mutation leads to uncontrolled obesity
3. Nanobubbles plus chemotherapy equals single-cell cancer targeting
4. A single stem cell mutation triggers fibroid tumors
5. New study discovers powerful function of single protein that controls neurotransmission
6. Variations of a single gene can lead to too much or too little growth, study shows
7. Made-in-Singapore H5N1 diagnostic kit -- detects all known strains of H5N1 virus with a single test
8. IU biologists offer clearer picture of how protein machine systems tweak gene expression
9. Making memories: How 1 protein does it
10. Embryonic development protein active in cancer growth
11. More effective method of imaging proteins
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/2/2015)... April 2, 2015 In ... by far outperforms the strongest competitors, showing outstanding ... accuracy, the system is capable of a throughput ... proves up to be ten times faster than ... runner-up performance.      (Photo: http://photos.prnewswire.com/prnh/20150402/738673-a ...
(Date:4/2/2015)... Sweden , April 2, 2015 ... for Q1 2015 attributed to somewhat higher than 125 ... in the year-end report 2014 that revenues for Q1 ... that the company reported for Q4 2014. The operating ... to be negative. The complete interim report will as ...
(Date:4/1/2015)... -- NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" or the ... mobile commerce market, announces the second shipment of a ... early access pre-order customers. Feedback from ... including Walmart, Target, AT&T, Dunkin, Donuts, Stop & Shop ... all outlets and very easy to use. Several users ...
Breaking Biology News(10 mins):DERMALOG AFIS Emerges as Performance Winner in NIST Benchmark Test 2DERMALOG AFIS Emerges as Performance Winner in NIST Benchmark Test 3Fingerprint Cards Revises Revenues for Q1 2015 2NXT-ID Reports Second Shipment of Wocket Smart Wallets Underway to Early Access Pre-order Customers and Provides User Feedback 2NXT-ID Reports Second Shipment of Wocket Smart Wallets Underway to Early Access Pre-order Customers and Provides User Feedback 3NXT-ID Reports Second Shipment of Wocket Smart Wallets Underway to Early Access Pre-order Customers and Provides User Feedback 4
... 2013) In a study of older mice, wolfberries appear ... against the flu virus. The research, led by scientists at ... (USDA HNRCA) at Tufts University, suggests the wolfberry may increase ... in the ability of the immune system to defend against ...
... It takes dozens of chemical reactions for a cell to ... type of living organism. Cholesterol, for example, an important component ... The molecule that gives oranges their citrusy smell and taste ... Now, researchers at the Salk Institute have discovered ...
... Ariz. To protect themselves, some animals rapidly ... change colors in unusual ways when they interact ... discovered that these color changes don,t happen "out-of-the-blue" ... during important social interactions. For example, when ...
Cached Biology News:Older mice fed wolfberries show reduced risk for flu virus with vaccine 2Missing molecule in chemical production line discovered 2Missing molecule in chemical production line discovered 3ASU researchers discover chameleons use colorful language to communicate 2
(Date:4/17/2015)... , April 17, 2015  US-Australian drug discovery ... a Memorandum of Understanding with the Feinstein Institute ... New York to collaborate with the ... The collaboration brings together the drug ... clinical expertise of the Feinstein Institute in neurosciences ...
(Date:4/17/2015)... (PRWEB) April 17, 2015 LC ... proteomics technologies, announced today that it is seeking ... an innovative multiplex PCR based targeted sequencing technology. ... sequence analysis, that enables accurate detection of rare ... and Omega-Primer™ technologies. The company will collaborate with ...
(Date:4/16/2015)... Spirax Sarco, the leader in ... newly designed, state-of-the-art website in the first quarter ... promotes the Spirax Sarco brand, company capabilities, and ... a site visitor might be looking for including ... serviced, the latest company news, careers, and much ...
(Date:4/16/2015)... 16, 2015 Cambridge Semantics ... driven by Semantic Web technology, and Informa ... and services for the academic and scientific, professional ... joint solution ‘Smart Data Lake for Clinical Trial ... the 2015 Bio-IT ‘Best of Show’ Award. ...
Breaking Biology Technology:Novogen and Feinstein Institute Join Forces to Find Effective Treatments for Brain Cancer 2Novogen and Feinstein Institute Join Forces to Find Effective Treatments for Brain Cancer 3Novogen and Feinstein Institute Join Forces to Find Effective Treatments for Brain Cancer 4Novogen and Feinstein Institute Join Forces to Find Effective Treatments for Brain Cancer 5Novogen and Feinstein Institute Join Forces to Find Effective Treatments for Brain Cancer 6LC Sciences Seeks Beta Testers of Targeted Sequencing Method Ahead of Q4 Launch 2LC Sciences Seeks Beta Testers of Targeted Sequencing Method Ahead of Q4 Launch 3Spirax Sarco website has a new look 2Cambridge Semantics and Informa Named Bio-IT Award Finalist for Smart Data Lake Solution for Clinical Trial and Competitive Intelligence 2Cambridge Semantics and Informa Named Bio-IT Award Finalist for Smart Data Lake Solution for Clinical Trial and Competitive Intelligence 3
... TUESDAY, NOVEMBER 4, 2008, SAN DIEGO, Oct. 27 ... that Kevin Gorman, President and Chief,Executive Officer of Neurocrine ... Conference in New York., The live presentation takes ... (ET) /7:00 a.m. Pacific Time (PT). The presentation will,be ...
... Pa., Oct. 27 BioTrends Research Group, Inc. ... privately-held businesses in,the Philadelphia region by the Philadelphia ... Development Center, the Entrepreneurs, Forum of,Greater Philadelphia, and ... verifiable revenue growth., "This recognition is a ...
... 27 Osteotech, Inc.,(Nasdaq: OSTE ) announced ... 2008 financial results will be released Friday, November ... Sam Owusu-Akyaw, President and,Chief Executive Officer, as well ... 7, 2008, at 9:00 a.m. Eastern time. You ...
Cached Biology Technology:Neurocrine Biosciences to Present at the Oppenheimer 19th Annual Healthcare Conference 2