Navigation Links
Single protein, key to ebola virus infection, could aid in drug design
Date:8/24/2011

nfection.

In the second Nature article on this topic, another team of USAMRIID scientists, working with investigators from Brigham and Women's Hospital and Harvard Medical School, independently arrived at the same conclusionthat Ebola virus needs NPC1 to enter the cell and cause infection.

The BWH group used a robotic method developed by Harvard's National Small Molecule Screening Laboratory to screen tens of thousands of compounds for activity against Ebola virus. They identified a novel small molecule that inhibits Ebola virus entry into cells by more than 99 percent.

Next, USAMRIID investigators Lisa Hensley, Ph.D. and Claire Marie Filone, Ph.D. verified that the newly identified inhibitor, or compound, blocked cell-to-cell transmission of Ebola virus. Using the inhibitor as a probe to investigate the pathway of infection, they found that the target of the inhibitor is NPC1the same cell protein described by the other research team. The findings suggest that small molecules that target NPC1 and inhibit Ebola virus infection have the potential to be developed into antiviral drugs.

"The fact that two groups identified the same protein, using two different experimental approaches, is significant," Dr. Dye commented. "This independent corroboration greatly increases our confidence in the findings."

Dr. Hensley said both studies represent the first step in a promising line of research that could make it possible for scientists to design therapeutics that impede the ability of the Ebola virus to infect and spread.

Both projects received funding support from the Defense Threat Reduction Agency (DTRA).


'/>"/>

Contact: Lori Calvillo
lori.calvillo@amedd.army.mil
US Army Medical Research Institute of Infectious Diseases
Source:Eurekalert

Page: 1 2

Related biology news :

1. Salk researchers successfully reprogram keratinocytes attached to a single hair
2. Reprogrammable cell type depends on a single gene to keep its identity
3. Einstein researchers develop technique to count messages made by single genes
4. Single adult stem cell can self renew, repair tissue damage in live mammal
5. Single virus used to convert adult cells to embryonic stem cell-like cells
6. Large DNA stretches, not single genes, shut off as cells mature
7. Single gene lets bacteria jump from host to host
8. Scientists discover why teeth form in a single row
9. Texas-sized tract of single-celled clones
10. Distinguishing single cells with nothing but light
11. Olympus advances technology for laparo-endoscopic single-site surgery
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/22/2014)... 22, 2014  NXT-ID, Inc. (NASDAQ: NXTD and ... on the growing mobile commerce market, announces it has retained ... for the 2015 International CES debut of the Wocket™ biometric ... be at the NXT-ID booth January 6th and 7 th ...
(Date:12/22/2014)... Holiday Season may be the brightest ever for the ... long anticipated floodgates for consumer biometrics may finally be ... tablets, and wearable mobile devices that incorporate biometrics will ... nearly 4.8 billion biometric devices by 2020.   ...
(Date:12/19/2014)... Research and Markets ( http://www.researchandmarkets.com/research/86ncd6/micro_market ) has announced ... Perimeter Security Systems Market" report to their offering. ... American perimeter security market is estimated to grow at a ... market holds a larger share in this market, ...
Breaking Biology News(10 mins):NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 2NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 3NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 4First Season of Holiday Shopping with Mobile Biometric Payments Wraps Up With a Present for Biometrics Industry: A Rosy Forecast for More Than 2 Billion Users of 4.8 Billion Mobile Biometric Devices by 2020 2Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 2Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 3
... A newly discovered parasite so dramatically transforms its host, an ... berry, ripe for picking, according to a report accepted for ... of fruit mimicry caused by a parasite, the co-authors say. ... birds into eating infected ants - parasites and all - ...
... delay the onset of Alzheimer,s disease, but none are able ... detection the key to Alzheimers patients maintaining a good quality ... a new device developed by the Georgia Institute of Technology ... inexpensive test that could be administered as part of a ...
... led by scientists at St. Jude Childrens Research Hospital ... vertebrates, and may translate into a deeper understanding of ... and how a rare pediatric eye cancer progresses. ... carefully orchestrated for the eye to form correctly, said ...
Cached Biology News:Ant parasite turns host into ripe red berry, biologists discover 2Ant parasite turns host into ripe red berry, biologists discover 3Portable device quickly detects early Alzheimer's 2Portable device quickly detects early Alzheimer's 3St. Jude defines eye cancer gene's role in retinal development 2
(Date:1/22/2015)... January 22, 2015 Diagenode, Inc., ... as the Bioruptor® and complete solutions for epigenetics ... chromatin immunoprecipitation, alleviating the need for manual processing. ... needed for ChIP of histones or transcription factors ...
(Date:1/22/2015)... N.J. , Jan. 22, 2015  Derma Sciences, ... regeneration company focused on advanced wound care, announces ... placental tissues, have been added to the Premier, ... increases the opportunity for the AMNIOEXCEL® and AMNIOMATRIX® ...
(Date:12/24/2014)...   BioLife Solutions , Inc. (NASDAQ: BLFS ), ... hypothermic storage and cryopreservation freeze media ... tissues  ("BioLife" or the "Company"), today announced that it will ... 2015 (the "Annual Meeting"). Because the expected date ...
(Date:12/24/2014)... On Friday, December 19, 2014, President ... Continuing Resolution Appropriations Act of 2015, which for the ... funding through the Congressionally Directed Medical Research Programs (CDMRP) ... Association (HA), working in conjunction with its allies on ...
Breaking Biology Technology:Diagenode Launches Unique Semi-Automated Solution for Chromatin Immunoprecipitation 2Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 2Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 3Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 4Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 5BioLife Solutions Sets Date for Annual Meeting of Stockholders 2Rare Brain Condition Now Eligible for Department of Defense Research Dollars 2
... For the second time in six years, a Madison ... infringement. , ,This time Hyperphrase Technologies has filed suit ... company, for allegedly using technology that provides viewers of ... advertisements. Hyperphrase claims that Google Toolbar features AutoLink and ...
... Wis. The trademark industry enjoyed another year ... of the Trademark Insider , a quarterly publication ... , a provider of trademark research and online brand ... legal communities with insight into overall trademark filing activity, ...
... Stones' albums, not necessarily their best mind you, growing up was ... and excitement of BIO 2006- Chicago. , ,As BIO 2006 - ... give my take on the outcome, but so many others have ... dust settles and some more of the facts emerge (like the ...
Cached Biology Technology:BIO 2006 aftermath and a taste of bio-generics 2BIO 2006 aftermath and a taste of bio-generics 3BIO 2006 aftermath and a taste of bio-generics 4BIO 2006 aftermath and a taste of bio-generics 5BIO 2006 aftermath and a taste of bio-generics 6BIO 2006 aftermath and a taste of bio-generics 7BIO 2006 aftermath and a taste of bio-generics 8
... WesternBreeze Immunodetection Kits are designed ... immobilized on nitrocellulose or PVDF membranes. ... (except membranes and primary antibodies), the ... both optimizing your protocol and getting ...
Carbonate-Bicarbonate Buffer Capsules. For use in coating ELISA plates. Dissolve contents of 1 capsule in 100 ml deionized water to yield 0.05 M carbonate-bicarbonate buffer, pH 9.6....
... Mouse Monoclonal to L1 Cell Adhesion ... which is located in Xq28, is involved ... of the aqueduct of Sylvius); 2) MASA ... and 3) SPG1 (spastic paraplegia). ...
...
Biology Products: