Navigation Links
Single protein, key to ebola virus infection, could aid in drug design
Date:8/24/2011

Research published by two teams of Army scientists and collaborators has identified a cellular protein that plays a critical role in Ebola virus infection. The findings, published online today in separate studies in the journal Nature, suggest a possible strategy for combating one of the world's most deadly viruses.

Ebola causes hemorrhagic fever with case fatality rates as high as 90 percent in humans. The virus is of concern both as a global public health threat and as a potential agent of biological terrorism. Currently there are no available vaccines or therapies to combat the disease. In addition, much is still unknown about the exact mechanism by which Ebola virus invades cells and causes infection.

In one Nature study, scientists from USAMRIID, Albert Einstein College of Medicine, the Whitehead Institute for Biomedical Research, and Harvard Medical School searched for proteins that Ebola virus might use to enter cells. One such cellular protein, known as Niemann-Pick C1 (NPC1), stood out: The team found that if cells don't make NPC1, they cannot be infected by Ebola virus.

According to the authors, the NPC1 protein is embedded within cell membranes, where it helps transport cholesterol within the cell. However, the absence of NPC1 due to gene mutations causes a rare degenerative disorder called Niemann-Pick disease, in which cells become clogged with cholesterol and eventually die.

To confirm the group's finding that NPC1 is crucial for Ebola virus infection, John M. Dye, Ph.D. and colleagues at USAMRIID used mice that were partially deficient in NPC1 expression, challenging the animals with lethal doses of Ebola virus. Remarkably, most of the mice survived the challenge. Other studies using cells from people with Niemann-Pick disease found that those cells also were resistant to Ebola virus infection. In addition, the researchers showed that treating cells with a compound that blocks NPC1 function inhibited i
'/>"/>

Contact: Lori Calvillo
lori.calvillo@amedd.army.mil
US Army Medical Research Institute of Infectious Diseases
Source:Eurekalert

Page: 1 2

Related biology news :

1. Salk researchers successfully reprogram keratinocytes attached to a single hair
2. Reprogrammable cell type depends on a single gene to keep its identity
3. Einstein researchers develop technique to count messages made by single genes
4. Single adult stem cell can self renew, repair tissue damage in live mammal
5. Single virus used to convert adult cells to embryonic stem cell-like cells
6. Large DNA stretches, not single genes, shut off as cells mature
7. Single gene lets bacteria jump from host to host
8. Scientists discover why teeth form in a single row
9. Texas-sized tract of single-celled clones
10. Distinguishing single cells with nothing but light
11. Olympus advances technology for laparo-endoscopic single-site surgery
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/13/2015)... , Jul. 13, 2015 NXT-ID, Inc. ... a biometric authentication company focused on the growing ... filed provisional patent 62/188684 for BEHAVIORAL-DIRECTED ... another new convenient and secure method to make ... innovative payment methods, introduced with its groundbreaking voice-direct ...
(Date:7/9/2015)... Research and Markets( ... "Biometrics for Banking; Market & Technology Analysis, ... their offering. The adoption for banking ... and the forecast is that by 2020 it ... involved in delivering biometric systems to the banking ...
(Date:7/9/2015)... JOSE, Calif. , July 9, 2015 ... the leading developer of human interface solutions, ... technology, the industry,s first fully hardware encapsulated ... Match-in-Sensor secure authentication technology is literally off ... storage and biometric matching within the fingerprint ...
Breaking Biology News(10 mins):NXT-ID Patents Behavior-Directed Payments 2NXT-ID Patents Behavior-Directed Payments 3NXT-ID Patents Behavior-Directed Payments 4Global Banking Biometrics Market 2015-2020 - Market & Technology Analysis, Adoption Strategies and Forecasts 2Global Banking Biometrics Market 2015-2020 - Market & Technology Analysis, Adoption Strategies and Forecasts 3Synaptics Announces World's First Match-in-Sensor Fingerprint Authentication Technology 2Synaptics Announces World's First Match-in-Sensor Fingerprint Authentication Technology 3
... (Jan. 25, 2012) --- A comprehensive investigation of flavanol ... in our understanding of how cocoa flavanols work in ... Through the development of improved analytical methods, this recent ... flavanols, which calls into question the reliability of ...
... College of Agricultural Sciences, The Pennsylvania State University, State College, ... Submissions: 1 March 2012 -- The Society for the ... for presentation at the 45th SSR Annual Meeting to be ... to the following are to be found on the ...
... is available in Spanish . The upsurge ... and affects crops in particular. However, Anabel Robredo, a biologist at ... the case of barley at least, climate change itself is providing ... change is in fact also responsible for a considerable increase in ...
Cached Biology News:Recent study by Mars, Incorporated and partners underscores importance of metabolism in understanding health benefits of cocoa flavanols 2Barley adapts to climate change 2Barley adapts to climate change 3
(Date:8/3/2015)... August 3, 2015 E-QURE Corp. ... of its Bio-electrical Signal Therapy device ("BST Device"), a ... hard to heal chronic wounds, today announced that the ... an Israeli distributor specializing in medical devices, for the ... Chemipal is a 70 years old, sales, marketing and ...
(Date:8/3/2015)... According to a new market ... Asia to Witness Highest Growth ... cell culture market was valued at US$ 586.1 Mn in ... of 29.1% to account for US$ 2,717.6 Mn by ... 3D cell culture refers to a ...
(Date:8/3/2015)... ... 03, 2015 , ... Sterlitech Corporation introduces the compact, quiet, ... analytical laboratory equipment. With optimized features, such as PTFE-coated contact surfaces, an oil-free ... maintenance-free solution for a broad range of vacuum filtration applications. , Featuring a ...
(Date:7/31/2015)... Dallas, Texas (PRWEB) , ... July 31, 2015 ... ... research report, offering competitive market analysis and premium industry insights on the global ... challenges, based on a collective study of vivid market scenarios and analysis of ...
Breaking Biology Technology:E-QURE Corp Signs Second Distribution Agreement in Israel 2E-QURE Corp Signs Second Distribution Agreement in Israel 3Global 3D Cell Culture Market Will Reach US$ 2,717.6 Million by 2020: Persistence Market Research 2Global 3D Cell Culture Market Will Reach US$ 2,717.6 Million by 2020: Persistence Market Research 3Global 3D Cell Culture Market Will Reach US$ 2,717.6 Million by 2020: Persistence Market Research 4Sterlitech Launches New Line of Vacuum Pumps 2Resorcinol Market to Grow at 6% CAGR to 2019 Says New Research Report at ReportsnReports.com 2Resorcinol Market to Grow at 6% CAGR to 2019 Says New Research Report at ReportsnReports.com 3Resorcinol Market to Grow at 6% CAGR to 2019 Says New Research Report at ReportsnReports.com 4
... and flat federal funding of biomedical research, five,important actions ... cost --,can yield dramatic results for patients and the ... (NCI) in a commentary published today by "The,Oncologist." , ... , In the article, James ...
... 07/06 2008 08/07, ... millions millions, ... 14, Other EU Countries 9.7 22 17 11.3 ... 3 10 2.0 4 45, SLIT ...
... Jan. 15 Regado Biosciences, Inc., announced today ... to the position of Senior Vice President, Clinical ... immediately. He will report to David J. ... Officer.Dr. Mazzo stated, "Steven has led clinical programs ...
Cached Biology Technology:National Cancer Institute: Battling Cancer and a Recession 2National Cancer Institute: Battling Cancer and a Recession 3Stallergenes: 2008: Sales Up 16% - Excellent Performance - Guidance Exceeded 2Stallergenes: 2008: Sales Up 16% - Excellent Performance - Guidance Exceeded 3Dr. Steven L. Zelenkofske Joins Regado Biosciences as Senior Vice President, Clinical and Medical Affairs and Chief Medical Officer 2Dr. Steven L. Zelenkofske Joins Regado Biosciences as Senior Vice President, Clinical and Medical Affairs and Chief Medical Officer 3
... This reagent is formulated specifically for ... consistently high levels of activity for both ... storage at final dilution. This product ... stability providing the customer a longer shelf ...
Request Info...
NovaScreen offers cell biology, cell culture and molecular biology services for companies who lack a cell culture facility....
... The Human Genetic Cell Bank Service ... is based on Epstein-Barr Virus (EBV) immortalisation ... in the production of lymphoblastoid cell lines ... providing a renewable and expandable source of ...
Biology Products: