Navigation Links
Single gene might explain dramatic differences among people with schizophrenia
Date:3/5/2013

the Kimel Family Translational Imaging-Genetics Research Laboratory at CAMH. "This may be a paradigm shift for the field."

The researchers studied MIR137 a gene involved in turning on and off other schizophrenia-related genes in 510 individuals living with schizophrenia. The scientists found that patients with a specific version of the gene tended to develop the illness at a younger age, around 20.8 years of age, compared to 23.4 years of age among those without this version.

"Although three years of difference in age-at-onset may not seem large, those years are important in the final development of brain circuits in the young adult," said Dr. Kennedy, Director of CAMH's Neuroscience Research Department. "This can have major impact on disease outcome."

In a separate part of the study involving 213 people, the researchers used MRI and diffusion tensor-magnetic resonance brain imaging (DT-MRI). They found that individuals who had the particular gene version tended to have unique brain features. These features included a smaller hippocampus, which is a brain structure involved in memory, and larger lateral ventricles, which are fluid-filled structures associated with disease outcome. As well, these patients tended to have more impairment in white matter tracts, which are structures connecting brain regions, and serving as the information highways of the brain.

Developing tests that screen for versions of this gene could be helpful in treating patients earlier and more effectively.

"We're hoping that in the near future we can use this combination of genetics and brain imaging to predict how severe a version of illness someone might have," said Dr. Voineskos. "This would allow us to plan earlier for specific treatments and clinical service delivery and pursue more personalized treatment options right from the start."


'/>"/>
Contact: Anita Dubey
anita.dubey@camh.ca
416-535-8501 x4932
Centre for Addiction and Mental Health
Source:Eurekalert

Page: 1 2

Related biology news :

1. Columbia Engineering and Penn researchers increase speed of single-molecule measurements
2. Researchers reveal how a single gene mutation leads to uncontrolled obesity
3. Nanobubbles plus chemotherapy equals single-cell cancer targeting
4. A single stem cell mutation triggers fibroid tumors
5. New study discovers powerful function of single protein that controls neurotransmission
6. Variations of a single gene can lead to too much or too little growth, study shows
7. Made-in-Singapore H5N1 diagnostic kit -- detects all known strains of H5N1 virus with a single test
8. Single protein promotes resistance to widely used anti-estrogen drugs
9. Single-cell parasites co-opt ready-made genes from host: UBC research
10. Breakthrough technology focuses in on disease traits of single cells
11. Iowa State, Ames Lab researchers invent new tool to study single biological molecules
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/24/2015)... PALM BEACH GARDENS, Fla. , March 24, ... of biometric identity management solutions, today announced that ... enabling premium clothing accessory retailer Goorin Bros ... login. The Crossmatch biometrics-based solution secures access to ... customers from the increased risk of data breaches. ...
(Date:3/23/2015)... 23, 2015  In the 2014 fiscal year, irs.gov ... losses. This figure accounts for a fraction of the ... Nilson Report, exceeds $11 billion globally. The polygraph has ... crime has occurred. Investor Mark Saint Juste ... Joe Paolella partnered to administer the test in ...
(Date:3/20/2015)... , Mar. 19, 2015 Research and Markets ... "Hand Geometry - Global Strategic Business Report" report ... markets for Hand Geometry in US$ Thousands. The report provides ... , Japan , Europe ... , and Rest of World. Annual estimates ...
Breaking Biology News(10 mins):Crossmatch Fingerprint Readers Help Retailer Prevent Data Breaches at Point-of-Sale 2Polygraph Test Now Used to Protect Investors From Fraud 2Polygraph Test Now Used to Protect Investors From Fraud 3Hand Geometry - Global Strategic Business Report 2015: An Essential Security Component for both Government & Enterprise Sector 2Hand Geometry - Global Strategic Business Report 2015: An Essential Security Component for both Government & Enterprise Sector 3Hand Geometry - Global Strategic Business Report 2015: An Essential Security Component for both Government & Enterprise Sector 4
... Patients who have high blood sugar before undergoing ... clots, deep vein thrombosis and even pulmonary embolism ... of anesthesiology in the Artificial Pancreas Center at ... Philadelphia, and his colleagues examined records of nearly ...
... protect against some food allergies. Kefir, a traditional fermented drink, ... is often used to wean babies, as it is easily ... the age of three, with around 5-8% of infants at ... food. , "Friendly" bacteria in kefir may play a role ...
... in the event of a large-scale smallpox bioterrorist attack ... by researchers at Fred Hutchinson Cancer Research Center that ... , Instead, the current U.S. government policy of post-release ... workers and close contacts would be sufficient to thwart ...
Cached Biology News:Jefferson scientists find high glucose before surgery raises risk of dangerous complications 2Friendly bacteria in alcoholic milkshake could fight food allergies 2Mass vaccination unnecessary in the event of a large bioterrorist US smallpox attack 2Mass vaccination unnecessary in the event of a large bioterrorist US smallpox attack 3Mass vaccination unnecessary in the event of a large bioterrorist US smallpox attack 4Mass vaccination unnecessary in the event of a large bioterrorist US smallpox attack 5
(Date:4/21/2015)... and RESEARCH TRIANGLE PARK, N.C. ... (NASDAQ: UTHR ) announced today that it will ... open on Tuesday, April 28, 2015. United ... 28, 2015, at 9:00 a.m. Eastern Time.  The teleconference ... 1-970-315-0533.  A rebroadcast of the teleconference will be available ...
(Date:4/21/2015)... Thornton Cleveleys (UK) (PRWEB) April 21, 2015 ... PEEK* technology and its clinical applications will ... Meeting. Participants include engineers, scientists, regulators and ... worldwide. The meeting is sponsored by Invibio ... PEEK polymer-based biomaterials, a specialist in manufacturing ...
(Date:4/21/2015)... CA (PRWEB) April 21, 2015 Whether it’s ... a lab, or bolted to a Kessler CineDrive ... or at the beach, the TS3-H is designed to help ... on a brand-new state-of-the-art 5MP sensor, the TS5-H offers the ... with superior imaging characteristics. , According to Tom Boldt ...
(Date:4/20/2015)... -- Stent retriever thrombectomy, an endovascular technique that ... reduced disability after stroke, according to a groundbreaking ... the Society of Vascular and Interventional Neurology (SVIN).  ... forward that will change the way we approach ... who is associate professor of Neurology and Neurosurgery ...
Breaking Biology Technology:2nd International PEEK Meeting: Invibio Biomaterial Solutions spearheads medical research for implantable PEEK polymer devices 22nd International PEEK Meeting: Invibio Biomaterial Solutions spearheads medical research for implantable PEEK polymer devices 3Fastec Imaging Releases the TS5-H High Definition High-Speed Camera 2Fastec Imaging Releases the TS5-H High Definition High-Speed Camera 3SVIN President Tudor Jovin, MD, Co-Leads Groundbreaking Stroke Study In The New England Journal Of Medicine 2SVIN President Tudor Jovin, MD, Co-Leads Groundbreaking Stroke Study In The New England Journal Of Medicine 3
... will potentially enable access to MRI exams for ... implantable cardiac ... Boston,Scientific Corporation (NYSE: BSX ) and Surgi-Vision, ... development arrangement for,magnetic resonance imaging (MRI)-safe technology. Physician implanters ...
... ... 2008, FT. MYERS, Fla., April 15 ... the,Securities and Exchange Commission its annual report on Form 10-KSB for the,year ended ... http://www.SEC.gov ., The audited financial statements for the year ended December ...
... April 15 Arpida Ltd.,(SWX: ARPN) today announced ... Thursday,17 April 2008 at 8.30am CET. In this ... need and developments in the area of anti-infective,drugs ... meeting of the Anti-Infective,Drugs Advisory Committee. During that ...
Cached Biology Technology:Boston Scientific and Surgi-Vision Announce Licensing Agreement for MRI-Safe Technology 2Boston Scientific and Surgi-Vision Announce Licensing Agreement for MRI-Safe Technology 3NeoGenomics Files Annual Report on Form 10-KSB with the SEC 2Arpida Announces Conference Call on 17 April 2Arpida Announces Conference Call on 17 April 3
Mouse monoclonal [7B9] to beta II Tubulin ( Abpromise for all tested applications). Antigen: Synthetic peptide, CEEEEGEDEA found at the c-terminus of beta II tubulin. Entrez GeneID: 10383 ...
Polymerase (RNA) II (DNA directed) polypeptide L...
...
...
Biology Products: