Navigation Links
Single episode of binge drinking can adversely affect health according to new UMMS study
Date:5/15/2014

WORCESTER, MA It only takes one time. That's the message of a new study by scientists at the University of Massachusetts Medical School on binge drinking. Their research found that a single episode of binge drinking can have significant negative health effects resulting in bacteria leaking from the gut, leading to increased levels of toxins in the blood. Published online in PLOS ONE, the study showed that these bacterial toxins, called endotoxins, caused the body to produce immune cells involved in fever, inflammation, and tissue destruction.

"We found that a single alcohol binge can elicit an immune response, potentially impacting the health of an otherwise healthy individual," said lead author Gyongyi Szabo, MD, PhD, professor of medicine, vice chair of the Department of Medicine and associate dean for clinical and translational sciences at UMMS. "Our observations suggest that an alcohol binge is more dangerous than previously thought."

Binge drinking is defined by National Institute on Alcohol Abuse and Alcoholism (NIAAA) as a pattern of drinking alcohol that brings blood alcohol concentration (BAC) to 0.08g/dL or above. For a typical adult, this corresponds with consuming five or more drinks for men, or four or more drinks for women, in about two hours, depending on body weight.

Binge drinking is known to pose safety risks associated with car crashes and injuries. Over the long term, binge drinking can damage the liver and other organs, but this is key evidence that a single alcohol binge can cause damaging health effects such as bacterial leakage from the gut into the blood stream, according to a statement released by George Koob, PhD, director of the NIAAA.

To assess the impact of binge drinking, 11 men and 14 women were given enough alcohol to raise their blood alcohol levels to at least .08 g/dL within an hour. Blood samples were then taken every 30 minutes for four hours after and again 24 hours later.

Szabo and colleagues found that the alcohol binge resulted in a rapid increase in endotoxin levels in the blood. Endotoxins are toxins contained in the cell wall of certain bacteria that are released when the cell is destroyed. They also found evidence of bacterial DNA in the bloodstream, showing that bacteria had permeated the gut. Compared to men, women had higher blood alcohol levels and circulating endotoxin levels.

Earlier studies have tied chronic alcohol use to increased gut permeability, wherein potentially harmful products can travel through the intestinal wall and be carried to other parts of the body. Greater gut permeability and increased endotoxin levels have been linked to many of the health issues related to chronic drinking, including alcoholic liver disease.


'/>"/>

Contact: Jim Fessenden
james.fessenden@umassmed.edu
508-856-2000
University of Massachusetts Medical School
Source:Eurekalert

Related biology news :

1. Columbia Engineering and Penn researchers increase speed of single-molecule measurements
2. Researchers reveal how a single gene mutation leads to uncontrolled obesity
3. Nanobubbles plus chemotherapy equals single-cell cancer targeting
4. A single stem cell mutation triggers fibroid tumors
5. New study discovers powerful function of single protein that controls neurotransmission
6. Variations of a single gene can lead to too much or too little growth, study shows
7. Made-in-Singapore H5N1 diagnostic kit -- detects all known strains of H5N1 virus with a single test
8. Single protein promotes resistance to widely used anti-estrogen drugs
9. Single-cell parasites co-opt ready-made genes from host: UBC research
10. Breakthrough technology focuses in on disease traits of single cells
11. Iowa State, Ames Lab researchers invent new tool to study single biological molecules
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/15/2016)... 2016 Recent publicized breaches in cyber security ... ways to ensure data security and user authentication in ... Android that ties a user,s mobile number ... a hardware authorization token. Customer service agents who employ ... their KodeKey enabled device to verify their identity.  Companies ...
(Date:1/11/2016)... 11, 2016 Synaptics Incorporated (NASDAQ: SYNA ... announced that its ClearPad ® TouchView ™ ... two separate categories in the 8 th Annual ... Technology Breakthrough. The Synaptics ® TDDI solution enables ... chain, thinner devices, brighter displays and borderless designs. ...
(Date:1/8/2016)... NXTD ), a company focused ... a privately held leading direct seller of vacation and ... fastest-growing company announced that on December 31, 2015, that ... Nxt-ID to develop a proprietary new wireless smart card ... a unique smart wallet that serves to securely store ...
Breaking Biology News(10 mins):
(Date:2/4/2016)... (PRWEB) , ... February 04, 2016 , ... ... talent development and compliance training, today announced an interactive FDA compliance training ... The RAPS (Regulatory Affairs Professional Society) accredited interactive course on Morf Playbook—now ...
(Date:2/4/2016)... -- Beike Biotechnology, the Shenzhen ... in late 2015 to mark their successful combined efforts ... --> --> The signing, ... Therapy" was hosted by the Shenzhen Cell Bank and ... Beike Biotechnology Co., Ltd. Shenzhen,s ...
(Date:2/4/2016)... , Feb. 4, 2016  Spherix Incorporated (Nasdaq: ... fostering and monetization of intellectual property, today provided an ... in the Northern District of Texas ... Inter Partes Re-examination ("IPR") proceedings ... Office.  The IPR was initiated on only certain claims ...
(Date:2/3/2016)... , Feb. 3, 2016   ViaCyte, Inc ... the first pluripotent stem cell-derived islet replacement therapy ... clinical-stage development, today announced that ViaCyte and Janssen ... of Johnson & Johnson, have agreed to consolidate ... ViaCyte.  The agreement provides ViaCyte with an exclusive ...
Breaking Biology Technology: