"The results demonstrate that MIDAS provides a much more efficient way to assemble whole bacterial genomes from single cells without culture," the authors write in the Nature Biotechnology paper.
The genomics researchers collaborated with materials science graduate student Yu-Jui (Roger) Chiu on the microfabrication required to create the arrays of microwells. Chiu is working on his Ph.D. in the lab of UC San Diego electrical engineering professor Yu-Hwa Lo, who also directs the Nano3 Labs in UC San Diego's Qualcomm Institute, where microfabrication took place.
"This project would not have succeeded without the fabrication and instrumentation support available at the Jacobs School and the Qualcomm Institute," said Zhang. "We are very excited about our initial results as well as the possibility that researchers around the world will be able to use this approach in many different contexts."
|Contact: Daniel Kane|
University of California - San Diego