Navigation Links
Simplicity is crucial to design optimization at nanoscale
Date:2/4/2009

MIT researchers who study the structure of protein-based materials with the aim of learning the key to their lightweight and robust strength have discovered that the particular arrangement of proteins that produces the sturdiest product is not the arrangement with the most built-in redundancy or the most complicated pattern. Instead, the optimal arrangement of proteins in the rope-like structures they studied is a repeated pattern of two stacks of four bundled alpha-helical proteins.

This composition of two repeated hierarchies (stacks and bundles) provides great strengththe ability to withstand mechanical pressure without giving wayand great robustnessthe ability to perform mechanically, even if flawed. Because the alpha-helical protein serves as the building block of many common materials, understanding the properties of those materials has been the subject of intense scientific inquiry since the protein's discovery in the 1940s.

In a paper published in the Jan. 27 online issue of Nanotechnology, Markus Buehler and Theodor Ackbarow describe a model of the protein's performance, based on molecular dynamics simulations. With their model they tested the strength and robustness of four different combinations of eight alpha-helical proteins: a single stack of eight proteins, two stacks of four bundled proteins, four stacks of two bundled proteins, and double stacks of two bundled proteins. Their molecular models replicate realistic molecular behavior, including hydrogen bond formation in the coiled spring-like alpha-helical proteins.

"The traditional way of designing materials is to consider properties at the macro level, but a more efficient way of materials' design is to play with the structural makeup at the nanoscale," said Buehler, the Esther and Harold E. Assistant Professor in the Department of Civil and Environmental Engineering. "This provides a new paradigm in engineering that enables us to design a new class of materials."

More and more frequently, natural protein materials are being used as inspiration for the design of synthetic materials that are based on nanowires and carbon nanotubes, which can be made to be much stronger than biological materials. The work of Buehler and Ackbarow, a graduate student at the Max Planck Institute of Colloids and Interfaces in Potsdam, Germany, demonstrates that by rearranging the same number of nanoscale elements into hierarchies, the performance of a material can be radically changed. This could eliminate the need to invent new materials for different applications.

In a follow-up study, Buehler and MIT graduate students Zhao Qin and Steve Cranford ran similar tests using more than 16,000 elements instead of eight. They found that 98 percent of the randomly arranged rope-like structures did not meet the optimal performance level of the self-assembled natural molecules, which made up the other 2 percent of the structures. The most successful of those again utilized the bundles of four alpha-helical proteins.

That analysis shows that random arrangements of elements typically lead to inferior performance, and may explain why many engineered materials are not yet capable of combining disparate properties such as robustness and strength.

"Only a few specific nanostructured arrangements provide the basis for optimal material performance, and this must be incorporated in the material design process," said Buehler.


'/>"/>
Contact: Denise Brehm
brehm@mit.edu
617-253-8069
Massachusetts Institute of Technology, Department of Civil and Environmental Engineering
Source:Eurekalert  

Related biology news :

1. Speed plays crucial role in breaking proteins H-bonds
2. Brown scientists say biodiversity is crucial to ecosystem productivity
3. Hidden infections crucial to understanding, controlling disease outbreaks
4. Mayo researchers identify dangerous two-faced protein crucial to breast cancer spread and growth
5. In lung cancer, silencing one crucial gene disrupts normal functioning of genome
6. IGERT fellows to design biodevices using flexible electronics
7. Researchers successfully simulate photosynthesis and design a better leaf
8. Synaptics SecurePad(TM) Selected as CES Innovations 2008 Design and Engineering Award Honoree
9. Singulex Teams With Wyeth Pharmaceuticals to Translate Pre-Clinical Biomarker Research Into Clinical Study Design
10. HIV isolate from Kenya provides clues for vaccine design
11. Book is the first high-resolution digital mouse brain atlas designed for Web applications
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Simplicity is crucial to design optimization at nanoscale
(Date:4/15/2016)... 15, 2016 Research and ... Biometrics Market 2016-2020,"  report to their offering.  , ... , ,The global gait biometrics market is expected ... the period 2016-2020. Gait analysis generates ... be used to compute factors that are not ...
(Date:4/13/2016)...  IMPOWER physicians supporting Medicaid patients in ... standard in telehealth thanks to a new partnership with ... IMPOWER patients can routinely track key health measurements, such ... and, when they opt in, share them with IMPOWER ... local retail location at no cost. By leveraging this ...
(Date:3/31/2016)... March 31, 2016  Genomics firm Nabsys has completed ... Barrett Bready , M.D., who returned to the ... original technical leadership team, including Chief Technology Officer, ... Development, Steve Nurnberg and Vice President of Software and ... company. Dr. Bready served as CEO of ...
Breaking Biology News(10 mins):
(Date:6/24/2016)... , June 24, 2016 Epic Sciences ... detects cancers susceptible to PARP inhibitors by targeting ... cells (CTCs). The new test has already been ... in multiple cancer types. Over 230 ... damage response pathways, including PARP, ATM, ATR, DNA-PK ...
(Date:6/23/2016)... June 23, 2016   Boston Biomedical , ... compounds designed to target cancer stemness pathways, announced ... granted Orphan Drug Designation from the U.S. Food ... gastric cancer, including gastroesophageal junction (GEJ) cancer. Napabucasin ... to inhibit cancer stemness pathways by targeting STAT3, ...
(Date:6/23/2016)... SANTA MONICA, Calif. , June 23, 2016  The Prostate Cancer ... to pioneer increasingly precise treatments and faster cures for prostate cancer. Members of ... 77 institutions across 15 countries. Read More About the ... ... ...
(Date:6/23/2016)... , ... June 23, 2016 , ... In a new ... in Denmark detail how a patient who developed lymphedema after being treated for breast ... results could change the paradigm for dealing with this debilitating, frequent side effect of ...
Breaking Biology Technology: