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Simpler way of making proteins could lead to new nanomedicine agents
Date:2/23/2011

t for the types of applications Cheng's group explores: nanostructures for drug and gene delivery, particularly targeting cancerous tumors and stem cells.

"We want to test the correlation of the lengths of the helices and the circulation in the body to see what's the impact of the shape and the charge and the side chains for clearance in the body," Cheng said. "Recent studies show that the aspect ratio of the nanostructures spherical structures versus tubes has a huge impact on their penetration of tumor tissues and circulation half-lives in the body."

Cheng plans to create a library of short helical polypeptides of varying backbone lengths, side chain lengths and types of charge. He hopes to simplify the chemistry even further and make the materials widely accessible. His lab already has demonstrated that helical structures can be effective gene delivery and membrane transduction agents, and building the library of soluble helical molecules will allow further investigation of tailoring such nanostructures for specific biomedical applications.


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Contact: Liz Ahlberg
eahlberg@illinois.edu
217-244-0173
University of Illinois at Urbana-Champaign
Source:Eurekalert  

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