Navigation Links
Simpler times: Did an earlier genetic molecule predate DNA and RNA?
Date:1/9/2012

uences obtained were 70 nucleotides in length, long enough Chaput says, to permit them to fold into shapes with defined binding sites. The DNA-TNA hybrids were then incubated with the target molecule thrombin. Sequences that bound with the target were recovered and amplified through PCR. The DNA portion was removed and used as a template for further amplification, while the TNA molecules displaying high-affinity, high specificity binding properties were retained.

Additionally, the binding affinity of the evolved and selected TNA molecules was tested against two other common proteins, for which they displayed no affinity, strengthening the case that a highly specific binding molecule had resulted from the group's directed evolution procedure.

Chaput suggests that issues concerning the prebiotic synthesis of ribose sugars and the non-enzymatic replication of RNA may provide circumstantial evidence of an earlier genetic system more readily produced under primitive earth conditions. Although solid proof that TNA acted as an RNA precursor in the prebiotic world may be tricky to obtain, Chaput points to the allure of this molecule as a strong candidate, capable of storing information, undergoing selection processes and folding into tertiary structures that can perform complex functions. This result provides the motivation to explore TNA as an early genetic system.

Chaput is optimistic that major questions about the prebiotic synthesis of TNA, its role in the origin and early evolution of life on earth, and eventual genetic takeover by RNA will, over time, be answered.


'/>"/>

Contact: Joseph Caspermeyer
Joseph.Caspermeyer@asu.edu
Arizona State University
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Simpler woodland strawberry genome aids research on more complex fruits
2. Simpler way of making proteins could lead to new nanomedicine agents
3. Health diagnosis made simpler
4. Compound screening for drug development made simpler
5. Just like old times: Generating RNA molecules in water
6. From heterogeneous patient measurements towards earlier diagnosis in Alzheimers disease
7. Hysterectomy increases risk for earlier menopause among younger women
8. UCLA researchers develop system that finds prostate cancer spread earlier than conventional imaging
9. When you can recite a poem but not remember who asked you to learn it a few days earlier
10. New understanding of biomarkers could lead to earlier diagnosis of fatal diseases
11. China fossil shows bird, crocodile family trees split earlier than thought
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/30/2014)... 2014 Winners of The Economist,s prestigious Innovation ... to take place at the JW Marriott Hong Kong on Friday, ... will share their experiences and the lessons those hold for others. ... innovation over the past decade, will be presented at a ceremony ... summit. It will be the first time the ceremony has come ...
(Date:9/29/2014)... DC September 29, 2014 -- Plants have ... bacteria help the pants extract nutrients and defend ... pathogens from contaminating fruits and vegetables. Now, scientist ... bacteria inside of seeds; thus ensuring that sprouting ... from the University of Notre Dame, presented their ...
(Date:9/29/2014)... school? According to a new Food and Brand Lab ... can increase participation in the National School Lunch Program ... vegetables by 16%! , Chefs Move to Schools (CMTS), ... chefs with schools in order to provide nutrition instruction ... service workers. , A CMTS event was held in ...
Breaking Biology News(10 mins):Hear from The Economist's 2014 Innovation Award Winners at Innovation Summit on October 10th in Hong Kong 2Hear from The Economist's 2014 Innovation Award Winners at Innovation Summit on October 10th in Hong Kong 3Hear from The Economist's 2014 Innovation Award Winners at Innovation Summit on October 10th in Hong Kong 4Hear from The Economist's 2014 Innovation Award Winners at Innovation Summit on October 10th in Hong Kong 5Hear from The Economist's 2014 Innovation Award Winners at Innovation Summit on October 10th in Hong Kong 6Hear from The Economist's 2014 Innovation Award Winners at Innovation Summit on October 10th in Hong Kong 7Plants prepackage beneficial microbes in their seeds 2Chefs move to schools can increase school meal participation and vegetable intake among students 2
... may hold the answer to making solar cells a ... of Engineering Physics at McMaster University, Cleanfield Energy and ... partnership to pursue the commercialization of nanowire technology in ... of nanowire technology developed at McMaster is able to ...
... 2008) Determined to revive the grossly depleted soils ... of poverty and hunger, the Alliance for a Green ... five-year program to restore the fertility of Africas soils. ... into soils where rapid nutrient loss is sapping the ...
... at the Picower Institute for Learning and Memory at MIT ... they have created a way to see, for the first ... circuit in a living animal. This revolutionary method allowed ... to see how bypassing a major memory-forming circuit in the ...
Cached Biology News:Nanowires hold promise for more affordable solar cells 2Alliance for a Green Revolution in Africa commits 180M to revive farmers' depleted soils 2Alliance for a Green Revolution in Africa commits 180M to revive farmers' depleted soils 3Alliance for a Green Revolution in Africa commits 180M to revive farmers' depleted soils 4New MIT tool probes brain circuits 2
(Date:9/30/2014)... , Sept. 30, 2014 Nematicide ... kill nematodes. Nematodes are microscopic parasitic roundworms, found ... and inside other plants and animals. Nematicides have ... or other properties promoting migration through the soil. ... than 1,000 plant-parasitic nematodes. With more than 10,000 ...
(Date:9/30/2014)... Md. , Sept. 30, 2014  RegeneRx ... today announced that it has received a Canadian ... by Actin-Sequestering Peptides.  This patent includes claims using ... numerous other actin-sequestering peptides for these purposes.  The ... About RegeneRx Biopharmaceuticals, Inc. ( www.regenerx.com ) ...
(Date:9/30/2014)... (PRWEB) September 30, 2014 OriginOil Inc. ... high-speed, chemical-free process to clean up large quantities of ... CEO Riggs Eckelberry reported on the launch of the ... a site provided by partner STW Resources . ... 1000 barrels per day (bpd) and achieved a 99.8% ...
(Date:9/30/2014)... Boston, MA (PRWEB) September 30, 2014 ... Core Facility Management Benchmarking study which focuses on ... the common challenges core managers face today. , In ... were revealed. One of note is the year-over-year decrease ... contributions. Core managers appear to be feeling the constraints ...
Breaking Biology Technology:Nematicides Market by Types (Fumigants, Organophosphates, Carbamate and Bio-Nematicides), Applications (Agrochemicals, Industrial, and Others), and Geography (North America, Europe, Asia-Pacific & ROW) - Global Trends & Forecasts to 2019 2RegeneRx Receives Canadian Patent for Inhibition or Reversal of Skin Aging 2OriginOil, Inc. Report to Shareholders: Blue Gold in West Texas 2iLab Solutions Announces the Results of the 2014 Core Facility Benchmarking Study 2iLab Solutions Announces the Results of the 2014 Core Facility Benchmarking Study 3
... Fiserv Inc. has unveiled a program of healthcare ... processing and health-plan administration. , ,Spurred on ... banking is a set of services which includes ... payments between parties in healthcare transactions. , ...
... The increased use of clinical technologies in healthcare does ... for care decisions, particularly when technology vendors include strong ... developers market their products more directly to consumers, they ... attendees of the recent Digital Healthcare Conference ...
... events, is coming to Milwaukee again on June 22 and 23 ... both global and Wisconsin-area technology companies. , ,The conference will feature ... Networks , Agilent , EqualLogic , Inacom , ... Runner Business Class and other companies. , ,Attendees will have ...
Cached Biology Technology:Liability issues not seen as roadblock to healthcare technology advancements 2Liability issues not seen as roadblock to healthcare technology advancements 3
PKC Sampler Kit 10 mu g each...
Golgi Sampler Kit 10g each...
Umbilical cord blood eosinophils, For immunohistochemistry (IHC)...
Monocyte-derived dendritic cells, For immunohistochemistry (IHC) Cell Chip with Human Umbilical Cord Blood Dendritic Cells...
Biology Products: