Navigation Links
Simple test helps predict heart attack risk
Date:3/10/2009

SAN DIEGO, Calif. (March 10, 2009)The use of common and readily available screening testslike the ankle brachial index (ABI)along with traditional risk scoring systemssuch as the Framingham Risk Scorehas the potential to prevent devastating heart attacks in thousands of individuals who are not originally thought to be at high risk (according to Framingham alone), say researchers at the Society of Interventional Radiology's 34th Annual Scientific Meeting. About 25 percent of all heart attacks or sudden cardiac deaths in the United States occur in individuals thought to be at low risk.

In the study, information was analyzed from the 1999-2004 National Health and Nutrition Examination Survey (NHANES)a nationally representative cross-sectional survey of the U.S. population for 6,292 men and women ages 40 and older without known history of heart disease, stroke, diabetes or atherosclerotic vascular diseasealong with available data on standard cardiovascular risk factors and screening tests (like the ABI, which is a comparative blood pressure test). For the first time, researchers determined the prevalence of peripheral arterial disease (PAD) in a large population of women and men who were not considered at high risk for cardiovascular disease. And the results are surprising: novel risk factors (those not traditionally considered in the Framingham Risk Score) are abnormal in up to 45 percent of those not considered high risk for coronary heart events.

"This is significant news that can profoundly impact public health. If novel risk factors are shown to improve risk prediction, they could be very valuable because the prevalence of abnormal values is high in populations not known to have high risk," said Timothy P. Murphy, M.D., an interventional radiologist and director of the Vascular Disease Research Center at Rhode Island Hospital in Providence. "These simple testslike ABI screeninghave the potential to improve the accuracy of cardiovascular risk prediction and thereby have significant public health impact by helping identify people for intensive medical therapy and preventing heart attacks and strokes," said Murphy.

While 91 percent of the NHANES group was considered at low or intermediate risk of cardiovascular disease, according to Framingham criteria alone, almost 45 percent of them were found to have at least one of three conditions: an abnormal ABI or elevated plasma fibrinogen or elevated plasma C-reactive protein (CRP). "Even with abnormal ABI, which was the least prevalent of the three novel risk factors evaluated, that number translates into about 2.1 million Americans, age 40 and older, who have no known history of heart disease, stroke, diabetes or atherosclerotic vascular disease," said Murphy. "There is also a good chance that ABI, which actually detects subclinical already-established atherosclerotic disease, may actually perform better in terms of risk prediction than fibrinogen or C-reactive protein because it may be more specific," Murphy said.

About 1.1 million Americans every year have heart attacks, and almost a third of those heart attacks results in death. Another 750,000 individuals experience stroke each year. Risk factorslike smoking, diabetes, high blood pressure and obesityincrease one's risk of heart attack and are associated with 75 percent of all heart attacks. However, the other 25 percent of heart attacks or sudden cardiac deaths occur in individuals not known to have risk factors and thought to be at low risk for cardiovascular disease. "The earlier the detection of who's at risk for heart attacks is crucial. Primary preventionsuch as initiating lifestyle changes and medical intervention directed at modifying risk factors (smoking cessation, blood glucose and blood pressure control, lowering cholesterol and exercise)can be started to improve one's health before costlier and more intensive interventions are needed," said Murphy.

"Interventional radiologists often provide PAD screening tests like the ABI. Primary care doctors, who oversee medical management of the vast majority of the public at risk for cardiovascular disease, should partner with interventional radiologists in evaluating patients' risk for cardiovascular disease, as well as for managing established PAD," said Murphy. ABI, used to diagnose PAD, is a painless test that compares the blood pressure in the legs to the blood pressure in the arms to determine how well the blood is flowing and whether further tests are needed. Elevated results for plasma fibrinogen and plasma C-reactive protein, laboratory-based tests, can indicate inflammation.


'/>"/>

Contact: Maryann Verrillo
mverrillo@SIRweb.org
703-460-5572
Society of Interventional Radiology
Source:Eurekalert

Related biology news :

1. Safe water: simpler method for analyzing radium in water samples cuts testing time
2. Gene regulation in humans is closer than expected to simple organisms
3. Researchers develop simple method to create natural drug products
4. Simple reason helps males evolve more quickly
5. Simple recipe turns human skin cells into embryonic stem cell-like cells
6. Simple screening questionnaire for kidney disease outperforms current clinical practice guidelines
7. Salt-tolerant gene found in simple plant nothing to sneeze at
8. Simple model cell is key to understanding cell complexity
9. Research measures movement of nanomaterials in simple model food chain
10. Genome of simplest animal reveals ancient lineage, confounding array of complex capabilities
11. At risk for peripheral arterial disease? Simple quiz provides key so you can circulate better
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/2/2017)... 1, 2017  Central to its deep commitment ... worldwide, The Japan Prize Foundation today announced the ... pushed the envelope in their respective fields of ... scientists are being recognized with the 2017 Japan ... only contribute to the advancement of science and ...
(Date:1/31/2017)... 2017  Spero Therapeutics, LLC, a biopharmaceutical company ... of bacterial infections, today announced it has acquired ... Pro Bono Bio Ltd (PBB) to bolster its ... forms of Gram-negative bacteria.   The assets acquired have ... PBB group company. "The acquisition of ...
(Date:1/26/2017)...  Crossmatch, a leading provider of security and identity ... combatting fraud, waste and abuse in assistance operations around ... on Disaster Relief conference in Panama City ... and foreign assistance organizations throughout Latin America ... a largely unacknowledged problem in the foreign assistance and ...
Breaking Biology News(10 mins):
(Date:2/20/2017)... (PRWEB) , ... February 20, ... ... leading US Joint Commission Accredited venture-backed teleradiology and telemedicine company announces at ... Healthineers. USARAD services are planned to be offered via a global cloud-based ...
(Date:2/20/2017)...  Atrius Health and IBM (NYSE: IBM ... to develop a cloud based service designed to ... view of the multiple influences on an individual,s ... be designed to support shared decision making between ... nonprofit healthcare organization with 875 physicians caring for ...
(Date:2/18/2017)... Research and Markets has announced the addition ... to their offering. ... The report provides separate comprehensive analytics for the US, ... of World. Annual estimates and forecasts are provided for the period ... these markets. Market data and analytics are derived from primary and ...
(Date:2/17/2017)... , Feb. 17, 2017  Protagonist Therapeutics, Inc. ... on its oral peptide drug candidates, PTG-100 and ... the European Crohn,s and Colitis Organization (ECCO).  The ... Barcelona, Spain from February 15 – ... preclinical data on Protagonist drug candidates PTG-100 and ...
Breaking Biology Technology: