Neurons come in an astounding assortment of shapes and sizes, forming a thick inter-connected jungle of cells. Now, UCL neuroscientists have found that there is a simple pattern that describes the tree-like shape of all neurons.
Neurons look remarkably like trees, and connect to other cells with many branches that effectively act like wires in an electrical circuit, carrying impulses that represent sensation, emotion, thought and action.
Over 100 years ago, Santiago Ramon y Cajal, the father of modern neuroscience, sought to systematically describe the shapes of neurons, and was convinced that there must be a unifying principle underlying their diversity.
Cajal proposed that neurons spread out their branches so as to use as little wiring as possible to reach other cells in the network. Reducing the amount of wiring between cells provides additional space to pack more neurons into the brain, and therefore increases its processing power.
New work by UCL neuroscientists, published today in Proceedings of the National Academy of Sciences, has revisited this century-old hypothesis using modern computational methods. They show that a simple computer program which connects points with as little wiring as possible can produce tree-like shapes which are indistinguishable from real neurons - and also happen to be very beautiful. They also show that the shape of neurons follows a simple mathematical relationship called a power law.
Power laws have been shown to be common across the natural world, and often point to simple rules underlying complex structures. Dr Herman Cuntz (UCL Wolfson Institute for Biomedical Research) and colleagues find that the power law holds true for many types of neurons gathered from across the animal kingdom, providing strong evidence for Ramon y Cajal's general principle.
The UCL team further tested the theory by examining neurons in the olfactory bulb, a part of the brain where ne
|Contact: Clare Ryan|
University College London