Navigation Links
Simple gut hormone combo makes our brains think we're full
Date:10/25/2011

Many of us would love nothing more than to trick ourselves into believing we are full even as our stomachs remain empty. Now, a new brain imaging study reported in the November issue of the Cell Press journal Cell Metabolism suggests there might just be a way. The key is to go with our guts just two gut hormones, that is.

The findings suggest that a simple hormone-inspired pill could be the long-sought answer to healthy eating, according to the researchers.

"Obesity is a major and rising problem," said Waljit Dhillo of Imperial College London. "The central dogma is we need to eat less, but that doesn't work so well. Understanding how the brain makes us feel hungry and full is an important issue for therapy."

As lunchtime approaches, our brains get excited at the very thought of that next meal, Dhillo explained. After we've eaten, the same foods that seemed so tempting to us in our hunger lose their sway.

The gut hormones peptide YY (PYY) and glucagon-like peptide 1 (GLP-1), which are both released into circulation after we eat, are known to play some role in that process. Studies in which people have been given one or the other of those hormones show a reduction in food intake and appetite. Still, no one knew what kind of influence those hormones really have on our brains.

Dhillo's team of scientists from Imperial College and GlaxoSmithKline used functional magnetic resonance imaging (fMRI) to measure brain activity in healthy people after they'd been given PYY and/or GLP-1 in a fasted state. Those scans were compared to the brains of those same individuals when they were full from eating a standard meal.

After a meal, people's brains responded less to images of food in regions related to food reward, and they ate less. A very similar thing happens to the brains and behaviors of hungry people after they've taken PYY and GLP-1 in combination.

"Participants had eaten no breakfast, but the pattern of their brain activity looked as if they had," Dhillo said. "There brain was tricked and they subsequently ate less of a buffet meal."

Each of the hormones worked to curb appetite on its own too, just to a lesser degree. The findings bolster the evidence in humans that these two hormones are key mediators of fullness. They might also have treatment implications.

"If we can mimic this effect in a pill that could be taken once a day or once a week, it may prove a useful treatment for obesity in the future," Dhillo said, noting that GLP-1 analogs are already prescribed for the treatment of diabetes.

Such a strategy might not only encourage us to eat less, but also to eat healthier. "When you are hungry, you tend to choose high-calorie foods," Dhillo said.


'/>"/>

Contact: Lisa Lyons
elyons@cell.com
617-386-2121
Cell Press
Source:Eurekalert

Related biology news :

1. Diversity of trees in Ecuadors Amazon rainforest defies simple explanation
2. Simple chemical procedure augments therapeutic potential of stem cells
3. A simple fusion to jump-start evolution
4. Artificial cells, simple model for complex structure
5. Simple test helps predict heart attack risk
6. Pitt-led researchers create quick, simple fluorescent detector for TB
7. Author says challenging simple concepts can save planet
8. Simple drug treatment may prevent nicotine-induced SIDS: Study
9. New blood tests promise simple, cost-effective diagnosis of gastrointestinal cancers
10. Scientists take step toward simple and portable tuberculosis tests for developing world
11. Simple test could offer cheap solution to detecting landmines
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/21/2017)... February 21, 2017 Der weltweite ... wachsen. Nach einem Gespräch mit mehr als 50 Vertretern aus ... zu überwinden gilt, um diese Prognose zu realisieren. ... ... Mobilisierung der finanziellen Mittel für die Biobank, die Implementierung ...
(Date:2/13/2017)... 13, 2017  RSA Conference -- RSA, a Dell ... designed to enhance fraud detection and investigation across ... RSA Fraud & Risk Intelligence Suite. The new ... additional insights from internal and external sources as ... their customers from targeted cybercrime attacks. ...
(Date:2/9/2017)... , Feb. 9, 2017 The biomass ... analysis of the biomass boiler market globally in terms ... of biomass boilers. The market for biomass boilers has ... type, end-user, application, and country/region. The market based on ... & forest residues, biogas & energy crops, urban residues, ...
Breaking Biology News(10 mins):
(Date:3/27/2017)... , March 27, 2017 Cousins Properties (NYSE: ... world,s leading biotechnology companies, has signed a 10-year, approximately 125,000 ... A office asset located in the Westshore submarket of ... thrilled that Amgen has chosen Corporate Center for their new ... Gellerstedt , president and chief executive officer of Cousins Properties. ...
(Date:3/27/2017)... Infectex Ltd., a Russian portfolio company of Maxwell Biotech Venture ... added to the standard drug therapy regimen in patients with multidrug-resistant pulmonary tuberculosis (MDR-TB). ... USA ) and the US National Institutes of Health. ... ... Logo ...
(Date:3/27/2017)...  Perthera,s Chief Bioinformatics Officer and research faculty member ... Ph.D., will be speaking at the American Medical Informatics ... 27, 2017, she will be speaking on the topic ... and Care" (from 10:30 a.m. – 12:00 p.m. PST) ... a participant in the "Making Precision Oncology Data More ...
(Date:3/27/2017)... ... , ... PMG Research is pleased to announce its participation in ... Forum in Boston on April 3-4, 2017. The CTC conference focuses on how the ... bring them closer to the patient. Clinical Trial Collaborations also will present an inaugural ...
Breaking Biology Technology: