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Simple fungus reveals clue to immune system protection
Date:4/21/2011

ng mechanism a so-called Dsc E3 ligase complex that resides in a compartment of the cell called the Golgi.

Sre1 is required for virulence in disease-causing fungi such as Aspergillus fumigatus, which ravage people whose immune systems have been weakened by cancer or infections. The dsc 1-4 genes, according to Espenshade, are conserved in Aspergillus as well as a number of other fungi that cause a range of diseases.

"Our studies suggest that dsc proteins are an attractive target for the development of new drugs to combat fungal infections in immune compromised people," Espenshade says.


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Contact: Maryalice Yakutchik
myakutc1@jhmi.edu
443-287-2251
Johns Hopkins Medical Institutions
Source:Eurekalert

Page: 1 2

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