Navigation Links
Simple fungus reveals clue to immune system protection
Date:4/21/2011

A discovery by Johns Hopkins scientists about how a single-celled fungus survives in low-oxygen settings may someday help humans whose immune systems are compromised by organ transplants or AIDS.

A report on the discovery in a yeast called Schizosaccharomyces pombe appears April 22 in Molecular Cell.

Previous work by the Hopkins team showed that Schizosaccharomyces pombe, a model organism that's often used to study individual genes, contains a protein named Sre1 that allows the organism to adapt to conditions in which oxygen is very low or missing altogether.

To find out what regulates Sre1, the researchers turned to their collection of 2,626 individual strains of fission yeast, each of which is modified to lack a different gene from the organism's genome. First, they subjected each of the mutant strains to low-oxygen conditions and identified 28 genes whose absence stopped the yeast from growing. Four of the mutants regained their ability to grow in low oxygen when the scientists added back Sre1.

"Unless something removes it, Sre1 stays attached to the cell membrane and therefore is unable to travel to the nucleus to do its job," says Peter J. Espenshade, Ph.D., an associate professor of physiology and member of the Center for Metabolism and Obesity Research at the Johns Hopkins University School of Medicine. "Only when cut and released from the membrane can SRE1 go to work."

To find that cutting mechanism, the researchers examined the four mutant yeast strains, looking for evidence of the molecular machinery that allows the short, active "business part" of Sre1 to make its way to the nucleus of the cell to turn on genes. Cells that can't cut Sre1 to activate it look and fare just like those that are completely missing it, Espenshade says.

The team identified four genes called defective for Sre cleavage (dsc 1-4) and showed that they are responsible for making the protein components of the cutti
'/>"/>

Contact: Maryalice Yakutchik
myakutc1@jhmi.edu
443-287-2251
Johns Hopkins Medical Institutions
Source:Eurekalert

Page: 1 2

Related biology news :

1. Diversity of trees in Ecuadors Amazon rainforest defies simple explanation
2. Simple chemical procedure augments therapeutic potential of stem cells
3. A simple fusion to jump-start evolution
4. Artificial cells, simple model for complex structure
5. Simple test helps predict heart attack risk
6. Pitt-led researchers create quick, simple fluorescent detector for TB
7. Author says challenging simple concepts can save planet
8. Simple drug treatment may prevent nicotine-induced SIDS: Study
9. New blood tests promise simple, cost-effective diagnosis of gastrointestinal cancers
10. Scientists take step toward simple and portable tuberculosis tests for developing world
11. Simple test could offer cheap solution to detecting landmines
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/14/2014)... published in Cancer Research shows SIRT6—a protein ... cancers—can promote the development of skin cancers by turning ... of sun-damaged skin cells. , Previously considered protective, SIRT6 ... sirtuins that help regulate genomic stability and prevent some ... repair DNA damage, which can lead to cancer. This ...
(Date:10/14/2014)... the house fly genome for the first time, revealing ... insect that thrives in pathogen-rich dung piles and garbage ... journal Genome Biology , will increase understanding of ... quickly adapt to resist insecticides, which could lead to ... carry and transmit more than 100 human and animal ...
(Date:10/14/2014)... Mount Sinai-led research team has discovered a new kind of ... a cell that lines liver blood vessels, according to a ... . The existence of such a cell type contradicts current ... embryo, and may hold clues to origins of, and future ... from a single cell into a complex being made up ...
Breaking Biology News(10 mins):Two-faced gene: SIRT6 prevents some cancers but promotes sun-induced skin cancer 2House fly genome reveals expanded immune system 2Stem cell discovery challenges dogma on how fetus develops; holds insights for liver cancer and reg 2Stem cell discovery challenges dogma on how fetus develops; holds insights for liver cancer and reg 3
... 19, 2012 A new study by scientists on ... in cell culture, a natural compound can virtually eliminate ... defines a novel class of HIV anti-viral drugs endowed ... and chronically infected cells. The HIV/AIDS pandemic continues ...
... , New Rochelle, NY, July 19, 2012To enable greater ... approaches such as co-firing of high percentages of biomass ... A comprehensive review of the strategies currently available and ... presented in I ndustrial Biotechnology , a peer-reviewed journal ...
... The Wyss Institute for Biologically Inspired Engineering at Harvard ... million contract (including option) from the Defense Advanced Research ... helps improve physical endurance for soldiers in the field. ... onset of fatigue, enabling soldiers to walk longer distances, ...
Cached Biology News:Scripps Research scientists show potent new compound virtually eliminates HIV in cell culture 2Strategies to improve renewable energy feedstocks 2Harvard's Wyss Institute to develop smart suit that improves soldiers' physical endurance 2
(Date:10/25/2014)... Durham, NC (PRWEB) October 24, 2014 ... appears to overcome several pitfalls of current skin grafting ... scarring and produces hair. The method, outlined in the ... a breakthrough for treating deep skin injuries that result ... skin injury completely destroys the skin’s regenerative elements. These ...
(Date:10/25/2014)... , October 24, 2014 Oramed ... pharmaceutical company focused on the development of oral drug ... Nadav Kidron will present at FireRock Capital,s Micro-Cap ... Annual Micro-Cap Conference ,Date: Tuesday, October 28, 2014 ,Time: ... New York City , ...
(Date:10/25/2014)... Biopharmaceuticals, Inc. (OTCBB: RGRX) ("the Company" or "RegeneRx") today ... on Thymosins in Health and Disease in ... beta 4 (TB4) linked with rhodamine (a fluorescent tracer ... rodent model of stroke, it was visualized outside of ... tissue of the brain).   The leakage of TB4 in ...
(Date:10/25/2014)... 2014 Research and Markets has ... Product , Research Area & by End User - ... In this report, the global epigenetics ... areas, and end users. The product segments of the ... & consumables, kits, and reagents. The subsegments of the ...
Breaking Biology Technology:New engineering method shows promise for faster healing, more cosmetically appealing skin grafts 2New engineering method shows promise for faster healing, more cosmetically appealing skin grafts 3Oramed to Present at the FireRock Annual Micro-Cap Conference 2Oramed to Present at the FireRock Annual Micro-Cap Conference 3Researchers Report Thymosin Beta 4 Crosses Blood-Brain Barrier In Animal Stroke Model 2Global Epigenetics (VLA, WBA, NBA, RTA, Rotary-Wing Aircraft) Market - Forecast to 2019 2Global Epigenetics (VLA, WBA, NBA, RTA, Rotary-Wing Aircraft) Market - Forecast to 2019 3
... difficult transfections when using the,complete control kit ... , We describe the vector pFB-ERV, an MMLV-based ... proteins RXR and VgEcR.,In stable cell lines infected ... induction ratios of greater than 200-fold are attainable ...
... One column purification of protein with native amino ... Wyborski * John C. Bauer * Barbara McGowan ... Systems, Inc. , Stratagene has improved the Affinity ... the pCAL-n-EK vector. This E. coli,cloning and expression ...
... highly specific digestion of purified,proteins or proteins in ... Claycomb * ChaoFeng Zheng * Denise Wyborski,* John ... Bernardino * Peter Vaillancourt ,Stratagene Cloning Systems, Inc. ... that cleaves at the carboxy terminus of its ...
Cached Biology Technology:pFB-ERV: Retroviral Delivery of the Ecdysone Receptor Proteins 2pFB-ERV: Retroviral Delivery of the Ecdysone Receptor Proteins 3pFB-ERV: Retroviral Delivery of the Ecdysone Receptor Proteins 4pFB-ERV: Retroviral Delivery of the Ecdysone Receptor Proteins 5pFB-ERV: Retroviral Delivery of the Ecdysone Receptor Proteins 6Expression and Purification of Recombinant Proteins That Have Native Amino,Acid Sequence 2Expression and Purification of Recombinant Proteins That Have Native Amino,Acid Sequence 3Expression and Purification of Recombinant Proteins That Have Native Amino,Acid Sequence 4Expression and Purification of Recombinant Proteins That Have Native Amino,Acid Sequence 5Expression and Purification of Recombinant Proteins That Have Native Amino,Acid Sequence 6Expression and Purification of Recombinant Proteins That Have Native Amino,Acid Sequence 7Expression and Purification of Recombinant Proteins That Have Native Amino,Acid Sequence 8Efficient Cleavage of Fusion Proteins to Yield Native Amino Termini 2Efficient Cleavage of Fusion Proteins to Yield Native Amino Termini 3Efficient Cleavage of Fusion Proteins to Yield Native Amino Termini 4
... has a long and outstanding history ... Several years ago we became aware ... was being modified to inject Xenopus ... redesigning the microdispenser to eliminate any ...
... power supply (Cat. No. Minis 150VS) is ... meet most electrophoresis needs in a personal, ... 150V power supply is capable of running ... designed for individuals to have his/her own ...
BD BioCoat Laminin 35 mm Culture Dishes, tissue-culture treated polystyrene with a uniform application of mouse laminin....
... a powerful application for DNA and ... interface, Expression makes complex computational analyses ... uses the very latest computing technology ... way sequences are analysed. Features include: ...
Biology Products: