Navigation Links
Simple blood test in the first trimester predicts fetal gender

Bethesda, MDA new research study published in the January 2012 edition of The FASEB Journal ( describes findings that could lead to a non-invasive test that would let expecting mothers know the sex of their baby as early as the first trimester. Specifically, researchers from South Korea discovered that various ratios of two enzymes (DYS14/GAPDH), which can be extracted from a pregnant mother's blood, indicate if the baby will be a boy or a girl. Such a test would be the first of its kind.

"Generally, early fetal gender determination has been performed by invasive procedures such as chorionic villus sampling or amniocentesis. However, these invasive procedures still carry a one to two percent risk of miscarriage and cannot be performed until 11 weeks of gestation. Moreover, reliable determination of fetal gender using ultrasonography cannot be performed in the first trimester, because the development of external genitalia is not complete," said Hyun Mee Ryu, M.D., Ph.D., a researcher involved in the work from the Department of Obstetrics and Gynocology at Cheil General Hospital and Women's Healthcare Center at the KwanDong University School of Medicine in Seoul, Korea. "Therefore, this can reduce the need for invasive procedures in pregnant women carrying an X-linked chromosomal abnormality and clarify inconclusive readings by ultrasound."

To make this discovery, Ryu and colleagues collected maternal plasma from 203 women during their first trimester of pregnancy. The presence of circulating fetal DNA was confirmed by a quantitative methylation-specific polymerase chain reaction of U-PDE9A. Multiplex real-time polymerase chain reaction was used to simultaneously quantify the amount of DYS14 and GAPDH in maternal plasma. The results were confirmed by phenotype at birth.

"Although more work must be done before such a test is widely available, this paper does show it is possible to predict the sex of a child as early as the first few weeks after conception," said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal. "At present, parents are sometimes given the wrong information about the sex of their unborn child; this test should prove helpful in resolving any uncertainties of today's ultrasound observations."

Contact: Cody Mooneyhan
Federation of American Societies for Experimental Biology

Related biology news :

1. Diversity of trees in Ecuadors Amazon rainforest defies simple explanation
2. Simple chemical procedure augments therapeutic potential of stem cells
3. A simple fusion to jump-start evolution
4. Artificial cells, simple model for complex structure
5. Simple test helps predict heart attack risk
6. Pitt-led researchers create quick, simple fluorescent detector for TB
7. Author says challenging simple concepts can save planet
8. Simple drug treatment may prevent nicotine-induced SIDS: Study
9. New blood tests promise simple, cost-effective diagnosis of gastrointestinal cancers
10. Scientists take step toward simple and portable tuberculosis tests for developing world
11. Simple test could offer cheap solution to detecting landmines
Post Your Comments:
(Date:11/19/2015)... -- Although some 350 companies are actively involved in molecular ... according to Kalorama Information. These include Roche Diagnostics, Hologic, Abbott ... of the 6.1 billion-dollar molecular testing market, according to ... Diagnostic s .    ... one company and only a handful of companies can ...
(Date:11/17/2015)... 17, 2015 Paris ... --> Paris , qui s,est ... DERMALOG, le leader de l,innovation biométrique, a inventé le ... et empreintes sur la même surface de balayage. Jusqu,ici, ... l,autre pour les empreintes digitales. Désormais, un seul scanner ...
(Date:11/12/2015)... 2015  A golden retriever that stayed healthy despite ... has provided a new lead for treating this muscle-wasting ... Institute of MIT and Harvard and the University of ... Cell, pinpoints a protective gene that ... effects. The Boston Children,s lab of Lou Kunkel ...
Breaking Biology News(10 mins):
(Date:11/24/2015)... Cepheid (NASDAQ: CPHD ) today announced ... conference, and invited investors to participate via webcast. ... December 1, 2015 at 11.00 a.m. Eastern Time ... December 1, 2015 at 11.00 a.m. Eastern Time ... York, NY      Tuesday, December 1, 2015 at ...
(Date:11/24/2015)... , Nov. 24, 2015 /CNW/ - iCo Therapeutics ... today reported financial results for the quarter ended ... expressed in Canadian dollars and presented under International ... United States ," said Andrew Rae ... advancements regarding iCo-008 are not only value enriching ...
(Date:11/24/2015)... ... November 24, 2015 , ... ... year and one of the premier annual events for pharmaceutical manufacturing: 2015 Annual ... November 2015, where ISPE hosted the largest number of attendees in more than ...
(Date:11/24/2015)... RALEIGH, N.C. , Nov. 24, 2015  Clintrax Global, Inc., ... Raleigh, North Carolina , today announced that the company has ... earnings represented a 391% quarter on quarter growth posted for Q3 ... Kingdom and Mexico , with the ... place in December 2015. --> United Kingdom ...
Breaking Biology Technology: