Navigation Links
Simons Foundation awards Emory scientists $3M for autism gene research
Date:10/4/2007

The Simons Foundation has awarded scientists at Emory University School of Medicine a three-year grant of more than $3 million to uncover genes on the X chromosome that may contribute to the development of autism.

Stephen T. Warren, PhD, chair of the Emory Department of Human Genetics, is principal investigator of the program project that also includes Michael Zwick, PhD, and Brad Coffee, PhD, both Emory faculty members in human genetics.

Autism occurs four to nine times more frequently in males than in females, and genes on the X chromosome have long been suspected as being responsible for this male predilection. However, the ability to comprehensively examine the entire X chromosome for abnormalities has not been technically feasible until now.

Using technologies recently developed in the Department of Human Genetics, the Emory scientists will carry out a comprehensive search for genetic abnormalities of the X chromosome in 330 patients with autism.

The first project will scan the entire length of the X chromosome for subtle deletions or duplications using high-resolution microarrays containing short DNA fragments that can interrogate 2.1 million sites on the X chromosome. The second project will sequence all of the 1,098 genes on the X chromosome using a "next generation" DNA sequencing instrument. The final project will scan the entire X chromosome for evidence of "epigenetic" abnormalities, which are due to differences in gene expression rather than changes in the DNA itself.

This exhaustive survey of the human X chromosome should identify X-linked variation for autism susceptibility if such variation exists, says Dr. Warren.

"The unique genomic technologies available at Emory allow studies that would have been incomprehensible only a few years ago and will enable us to examine the 155 million bases of the X chromosome in minute detail in patients with autism," he explains.

Finding a predisposing gene is considered the most important first step to uncovering the true basis of a disease and to developing diagnostic tests and therapeutic approaches.


'/>"/>

Contact: Holly Korschun
hkorsch@emory.edu
404-727-3990
Emory University
Source:Eurekalert

Related biology news :

1. W.M. Keck Foundation funds study of friendly microbes
2. Digging in the dirt for lifes biochemical foundations
3. Protein folding: Building a strong foundation
4. Emory Study Tests Bone Marrow Stem Cells to Improve Circulation in Legs
5. Researchers Uncover Key Step In Manufacture of Memory Protein
6. Emory Eye Center Implants Its First Retinal Chips In Patients With Retinitis Pigmentosa
7. Nanogen Issued Patent for Electronic Microarray With Memory
8. Rats infected as newborns grew up vulnerable to memory problems during an immune challenge
9. Structure-building cell signals also may influence learning and memory
10. Mice brains shrink during winter, impairing some learning and memory
11. Montreal researchers probe the genetic basis of memory
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/11/2016)... LIVERMORE, Calif. , Feb. 11, 2016  Vigilant Solutions ... commercial LPR data are being used by Lee,s ... residents, including the recent location and arrest of a homicide ... Lee,s Summit covers around 65 square miles and ... Police Department has a single mobile license plate ...
(Date:2/9/2016)... Aware, Inc. (NASDAQ: AWRE ), a leading supplier of biometrics ... and year ended December 31, 2015.  --> ... was $6.9 million, an increase of 61% compared to $4.3 million ... quarter of 2015 was $2.6 million compared to $0.2 million in ... --> Higher revenue and operating income in the fourth ...
(Date:2/8/2016)... 2016 Worldcore is ... innovation for clients, comfort and unbeatable security, with ... --> Worldcore is the first EU-regulated ... comfort and unbeatable security, with a Voice Biometrics ... Worldcore is the first EU-regulated global payment ...
Breaking Biology News(10 mins):
(Date:2/11/2016)... Florida , February 11, 2016 ... PositiveID Corporation ("PositiveID" or "Company") (OTCQB: PSID), a ... announced today that its Thermomedics subsidiary, which markets ... on its growth plan in January 2016, including ... distributors, increasing sequential monthly sales growth, and establishing ...
(Date:2/11/2016)... MIAMI (PRWEB) , ... February 11, 2016 , ... ... in regenerative medicine, has announced a new agreement with Bankok,Thailand-based Global Stem Cells ... researchers and phsyicians in 15 Latin American countries, including Mexico, Costa Rica, Dominican ...
(Date:2/10/2016)... , February 10, 2016 Early-career researchers ... , Peru , Uganda and ... life-enhancing work in health and nutrition   Indonesia ... Uganda and Yemen are being ... and epidemiology. They are also celebrated for mentoring young women scientists who ...
(Date:2/10/2016)... ASAE is introducing a hybrid membership model which will ... of joining or renewing through an organizational purchasing model. ... every employee in any size association or AMC office ... member benefits.   John H. Graham, IV ... allow organizations of any size and their employees to ...
Breaking Biology Technology: