Navigation Links
Silk microneedles deliver controlled-release drugs painlessly
Date:12/21/2011

ug delivery mechanism. But their development has been limited by constraints ranging from harsh manufacturing requirements that destroy sensitive biochemicals, to the inability to precisely control drug release or deliver sufficient drug volume, to problems with infections due to the small skin punctures.

The process developed by the Tufts bioengineers addresses all of these limitations. The process involves ambient pressure and temperature and aqueous processing. Aluminum microneedle molding masters were fabricated into needle arrays of about 500 m needle height and tip radii of less than 10 m. The elastomer polydimethylsiloxane (PDMS) was cast over the master to create a negative mold; a drug-loaded silk protein solution was then cast over the mold. When the silk was dry, the drug-impregnated silk microneedles were removed. Further processing through water vapor annealing and various temperature, mechanical and electronic exposures provided control over the diffusity of the silk microneedles and drug release kinetics.

"Changing the structure of the secondary silk protein enables us to 'pre-program' the properties of the microneedles with great precision," said David L. Kaplan, Ph.D., coauthor of the study, chair of biomedical engineering at Tufts and a leading researcher on silk and other novel biomaterials. "This is a very flexible technology that can be scaled up or down, shipped and stored without refrigeration and administered as easily as a patch or bandage. We believe the potential is enormous."


'/>"/>
Contact: Kim Thurler
kim.thurler@tufts.edu
617-627-3175
Tufts University
Source:Eurekalert

Page: 1 2

Related biology news :

1. ID Solutions Achieves Full-Production Delivery and Payment for Fingerprint Processing Software for TWIC
2. Jefferson scientists deliver toxic genes to effectively kill pancreatic cancer cells
3. Sig-Tec(R) and BIO-key(R) Deliver Advanced Biometric Security Solution to Ohio County Law Enforcement Agency
4. RNA molecules, delivery system improve vaccine responses, effectiveness
5. Self-assembling nano-fiber gel delivers high concentrations of clinically approved drugs
6. Depression during pregnancy can double risk of preterm delivery
7. New type of vaccines deliver stronger and faster immune response
8. MIT: Jeremy Nathans to deliver Scolnick Prize lecture
9. Nanotechnology holds promise for STD drug delivery
10. Striata and CIC Launch Integrated eSignature, eDelivery, and eBilling for the Financial Services Industry
11. Bulls-eye electrode helps interpret thoughts, deliver stimulus to aid paralyzed, epileptic patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/4/2014)... Fla. (November 4, 2014) — Think about the way ... How do neighboring cells know that they are supposed ... how do these tissues find the correct place and ... answering these crucial questions. , In a new study, ... to communicate with their surrounding neighbors, at the head-trunk ...
(Date:11/4/2014)... , November 4, 2014   ... vertical market growth   Fuel3D , a ... closed a funding round totaling $6.4 million (£4 million). This ... funding secured earlier this year and paves the way for ... 2015. The funding round was led by Chimera ...
(Date:11/4/2014)... 2014   Neurotechnology , a provider of ... latest version of its fingerprint matching algorithm has ... evaluation organized by NIST. The MINEX test ... INCITS 378 fingerprint standard template format. MINEX compliance ... in the United States ...
Breaking Biology News(10 mins):The inside story: How the brain and skull stay together 2Fuel3D Secures $6.4 Million in Expansion Funding 2Fuel3D Secures $6.4 Million in Expansion Funding 3Neurotechnology Places Second in Ongoing MINEX Ranking for Fingerprint Matching Algorithms 2Neurotechnology Places Second in Ongoing MINEX Ranking for Fingerprint Matching Algorithms 3
... and the ECI Biochemical Engineering Conferences have announced ... at the University of Delaware and Director of the ... Biochemical Engineering Journal Young Investigator Award. This ... contributed to the field of biochemical engineering by a ...
... examining chromosomes in human eggs a few hours after ... a healthy baby, a researcher told the 25th annual ... Embryology today (Monday 29 June). Dr. Elpida Fragouli, from ... UK, and Reprogenetics UK, said that her team,s work ...
... Approximately 58 km southeast of Shingu City, Japan--Deepsea Drilling ... Nankai Trough Seismogenic Zone off the Kii Peninsula of ... in water depths of 2,054 meters. Following sea floor ... blow-out prevention (BOP) system into an upper section of ...
Cached Biology News:Kelvin Lee winner of Biochemical Engineering Journal Young Investigator Award 2New, less invasive genetic test greatly improves pregnancy rates in older women with poor prognosis 2New, less invasive genetic test greatly improves pregnancy rates in older women with poor prognosis 3First riser-drilling research operations undertaken 2
(Date:11/22/2014)... 2014 The “Chiral Chromatography Columns ... Material (Metal, Glass, Plastic), by Application [GC, LC ... Forecast to 2018” analyses and studies the major ... America, Europe, Asia, and Rest of the World. ... figures spread through 135 pages and in-depth TOC ...
(Date:11/22/2014)...  The element of surprise has been a major ... without warning. Until now, epidemiologists had nothing to measure ... resulting in suboptimal responses to both the H1N1 pandemic ... Photo - http://photos.prnewswire.com/prnh/20141121/160242 That ... virus gene structural changes have been found that invariably ...
(Date:11/21/2014)... November 21, 2014 , ...   Mariano Rodríguez es elegid vicepresidente senior ... KLOX está en marcha para comenzar de forma rápida ... heridas de reciente aprobación en Europa   , ... complace al anunciar los siguientes nombramientos: Todd ...
(Date:11/21/2014)... BELLINGHAM, Washington, USA (PRWEB) November 19, 2014 ... used in our lives was shared with more than ... undergraduate and postgraduate students from the University of Otago ... Outreach Grant . The Otago students, members of the ... Southland New Zealand in early September, giving children from ...
Breaking Biology Technology:Chiral Chromatography Columns Market worth $87.8 Million by 2018 - New Research Report by MarketsandMarkets 2Chiral Chromatography Columns Market worth $87.8 Million by 2018 - New Research Report by MarketsandMarkets 3Chiral Chromatography Columns Market worth $87.8 Million by 2018 - New Research Report by MarketsandMarkets 4Chiral Chromatography Columns Market worth $87.8 Million by 2018 - New Research Report by MarketsandMarkets 5Viruses' Advantage of Surprise is Lost 2KLOX Technologies anuncia sus nombramientos ejecutivos 2KLOX Technologies anuncia sus nombramientos ejecutivos 3KLOX Technologies anuncia sus nombramientos ejecutivos 4KLOX Technologies anuncia sus nombramientos ejecutivos 5Optics and photonics outreach programs share science, spark fascination with light 2Optics and photonics outreach programs share science, spark fascination with light 3
... Presented at the Pediatric Academic Societies Annual Meeting ... Statistically-Significant Association between SpCO and Measures of Lung ... /PRNewswire-FirstCall/ -- Masimo (Nasdaq: ... Measure-Through Motion and Low-Perfusion pulse oximetry, announced today ...
... Insmed Inc. (Nasdaq: INSM ), a biopharmaceutical company, today reported results ... , , ... Finalized sale of follow-on biologics (FOB) assets to Merck & Co., ... Net of finance and ...
... Pharmaceuticals, Inc. (Nasdaq: AMLN ) will be presenting ... Tuesday, May 19, 2009 at 11:30 a.m. ET / 8:30 ... chief executive officer of Amylin Pharmaceuticals, will provide a corporate ... a recording will be made available following the event. The ...
Cached Biology Technology:New Study Funded By the National Institutes of Health (NIH) Finds Masimo SpCO(R) May Provide a Noninvasive Measure of Acute Asthma Severity in Children 2New Study Funded By the National Institutes of Health (NIH) Finds Masimo SpCO(R) May Provide a Noninvasive Measure of Acute Asthma Severity in Children 3New Study Funded By the National Institutes of Health (NIH) Finds Masimo SpCO(R) May Provide a Noninvasive Measure of Acute Asthma Severity in Children 4New Study Funded By the National Institutes of Health (NIH) Finds Masimo SpCO(R) May Provide a Noninvasive Measure of Acute Asthma Severity in Children 5Insmed Announces First Quarter 2009 Financial Results 2Insmed Announces First Quarter 2009 Financial Results 3Insmed Announces First Quarter 2009 Financial Results 4Insmed Announces First Quarter 2009 Financial Results 5Insmed Announces First Quarter 2009 Financial Results 6Insmed Announces First Quarter 2009 Financial Results 7Insmed Announces First Quarter 2009 Financial Results 8Insmed Announces First Quarter 2009 Financial Results 9
...
Mouse monoclonal antibody raised against a partial recombinant ZNF155. NCBI Entrez Gene ID = ZNF155...
Mouse polyclonal antibody raised against a partial recombinant COASY. NCBI Entrez Gene ID = 80347...
... Antibody against Nonmuscle Myosin II Heavy ... (Stored in TBS + 0.03% Thimerosal) ... peptide SDVNETQPPQSE corresponding to the C-terminus ... B (MHC-B) This antibody is effective ...
Biology Products: