Navigation Links
Silk microneedles deliver controlled-release drugs painlessly
Date:12/21/2011

MEDFORD/SOMERVILLE, Mass. -- Bioengineers at Tufts University School of Engineering have developed a new silk-based microneedle system able to deliver precise amounts of drugs over time and without need for refrigeration. The tiny needles can be fabricated under normal temperature and pressure and from water, so they can be loaded with sensitive biochemical compounds and maintain their activity prior to use. They are also biodegradable and biocompatible.

The research paper "Fabrication of Silk Microneedles for Controlled-Release Drug Delivery" appeared in Advanced Functional Materials December 2 online in advance of print.

The Tufts researchers successfully demonstrated the ability of the silk microneedles to deliver a large-molecule, enzymatic model drug, horseradish peroxidase (HRP), at controlled rates while maintaining bioactivity. In addition, silk microneedles loaded with tetracycline were found to inhibit the growth of Staphylococcus aureus, demonstrating the potential of the microneedles to prevent local infections while also delivering therapeutics.

"By adjusting the post-processing conditions of the silk protein and varying the drying time of the silk protein, we were able to precisely control the drug release rates in laboratory experiments," said Fiorenzo Omenetto, Ph.D., senior author on the paper. "The new system addresses long-standing drug delivery challenges, and we believe that the technology could also be applied to other biological storage applications."

The Drug Delivery Dilemma

While some drugs can be swallowed, others can't survive the gastrointestinal tract. Hypodermic injections can be painful and don't allow a slow release of medication. Only a limited number of small-molecule drugs can be transmitted through transdermal patches. Microneedlesno more than a micron in size and able to penetrate the upper layer of the skin without reaching nervesare emerging as a painless new dr
'/>"/>

Contact: Kim Thurler
kim.thurler@tufts.edu
617-627-3175
Tufts University
Source:Eurekalert

Page: 1 2

Related biology news :

1. ID Solutions Achieves Full-Production Delivery and Payment for Fingerprint Processing Software for TWIC
2. Jefferson scientists deliver toxic genes to effectively kill pancreatic cancer cells
3. Sig-Tec(R) and BIO-key(R) Deliver Advanced Biometric Security Solution to Ohio County Law Enforcement Agency
4. RNA molecules, delivery system improve vaccine responses, effectiveness
5. Self-assembling nano-fiber gel delivers high concentrations of clinically approved drugs
6. Depression during pregnancy can double risk of preterm delivery
7. New type of vaccines deliver stronger and faster immune response
8. MIT: Jeremy Nathans to deliver Scolnick Prize lecture
9. Nanotechnology holds promise for STD drug delivery
10. Striata and CIC Launch Integrated eSignature, eDelivery, and eBilling for the Financial Services Industry
11. Bulls-eye electrode helps interpret thoughts, deliver stimulus to aid paralyzed, epileptic patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/17/2014)... Research and Markets ( http://www.researchandmarkets.com/research/9zq33j/global_chemical ... "Global Chemical Sensor Market 2015-2019" report to ... One major trend upcoming in ... sensors in biomedical applications. Chemical sensors help in ... diagnosis during surgical procedures. The Global Chemical Sensor ...
(Date:12/15/2014)... DUBLIN , Dec. 12, 2014 Research ... announced the addition of the "Global Facial ... http://photos.prnewswire.com/prnh/20130307/600769 ... the identification of individuals. Facial recognition system measures ... as nose, jaw edges, mouth, and the distance ...
(Date:12/11/2014)... DUBLIN , Dec. 09, 2014 Research ... http://photos.prnewswire.com/prnh/20130307/600769 ( http://www.researchandmarkets.com/research/9ql3kr/biometrics_market ) ... Market in India 2015-2019" report to their ... in this market is the adoption of multimodal ... one characteristic of an individual for verification and ...
Breaking Biology News(10 mins):Global Chemical Sensor Market 2015-2019: Key Vendors are Abbott Laboratories, Bayer, Hoffmann La-Roche, Johnson & Johnson, NGK Spark Plugs and Robert Bosch 2Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 2Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 3Biometrics Market in India 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2
... accelerator facility to assess radiation risks that astronauts will be ... its accelerator is the only one in Europe able to ... determine possible health risks of manned space flights, scientists from ... of ion beams in human cells and organs. The first ...
... brain is plastic, according to recent findings in neuroscience, ... learning. Brain plasticity is the focus of a gathering ... other countries, to be held in Massachusetts at the ... Brain conference was co-founded by Kenneth S. Kosik, co-director ...
... to be analysed in a 30 million follow up to ... ever study of the genetics behind common diseases. The seven-fold ... allow researchers to look at a 25 diseases as well ... responses to statins. Funded by the Wellcome Trust, this ...
Cached Biology News:Missions to Mars 2Learning and the brain 2Learning and the brain 3Learning and the brain 4Largest ever study of genetics of common disease just got bigger 2
(Date:12/19/2014)... --Research and Markets ( http://www.researchandmarkets.com/research/fhh9rj/technology ) ... Innovations in Smart Fabrics (Technical Insights)" report ... http://photos.prnewswire.com/prnh/20130307/600769 The Research Service titled ... assessment on technological advancements and market for Smart ... 1. The Smart Fabrics market is expected to ...
(Date:12/19/2014)... CAMBRIDGE, MA (PRWEB) December 18, 2014 ... adults in the United States suffer from one or ... arthritis, asthma, or cancer. Medication can address some of ... to daily activities that many sufferers face. While implanted ... surgery and stimulate the whole nerve, which can induce ...
(Date:12/19/2014)... , Dec. 18, 2014  Decision Resources Group ... dental biomaterial market will grow moderately through 2023 as ... and growing awareness of dental biomaterials all spur procedure ... such as China and ... bring dental procedures within reach for a larger proportion ...
(Date:12/17/2014)... Based on the revenues gained from surgical imaging ... by four major players contributing to approximately 74% ... GE Healthcare (U.K.), Siemens AG (Germany), Philips (Netherlands), ... Copy at http://www.marketsandmarkets.com/Market-Reports/surgical-imaging-market-210534462.html , The leading ... its strong product portfolio, which includes its flagship ...
Breaking Biology Technology:Technology Innovations in Smart Fabrics (Technical Insights) 2Draper Wins GSK Funding for Smaller, Smarter Implantable Devices 2Asia Pacific Dental Biomaterial Market Will Grow Strongly Through 2023 2Asia Pacific Dental Biomaterial Market Will Grow Strongly Through 2023 3Global Refurbished Surgical Imaging Market by Product & Application is Estimated to Reach $1.25 Billion by 2019 - New Research Report by MarketsandMarkets 2Global Refurbished Surgical Imaging Market by Product & Application is Estimated to Reach $1.25 Billion by 2019 - New Research Report by MarketsandMarkets 3Global Refurbished Surgical Imaging Market by Product & Application is Estimated to Reach $1.25 Billion by 2019 - New Research Report by MarketsandMarkets 4
... R.I., Jan. 5, 2012  Nabsys, Inc., has initiated ... by announcing the appointment of Stan Rose, Ph.D., ... is also announcing that Jeffrey Sklar, M.D., Ph.D., ... board. Nabsys is pioneering the development ...
... Jan. 5, 2012   Life Technologies Corporation (NASDAQ: ... certification body of Association Francaise de Normalisation (AFNOR) for ... MicroSEQ® Listeria monocytogenes assays, molecular ... the presence or absence of this food-borne pathogen that ...
... 2012 RSB Spine, LLC, a medical device company ... surgical treatment of degenerative disc disease, today announced a ... Commenting on the revenue improvement, RSB Spine Chief ... year was especially rewarding considering the overall spine market ...
Cached Biology Technology:Nabsys Expands Leadership Team to Prepare for Commercialization of Novel DNA Positional Sequencing Technology 2Nabsys Expands Leadership Team to Prepare for Commercialization of Novel DNA Positional Sequencing Technology 3Nabsys Expands Leadership Team to Prepare for Commercialization of Novel DNA Positional Sequencing Technology 4Life Technologies Receives AFNOR Validation for Tests Designed to Detect Listeria Contamination in Food Samples 2Life Technologies Receives AFNOR Validation for Tests Designed to Detect Listeria Contamination in Food Samples 3Life Technologies Receives AFNOR Validation for Tests Designed to Detect Listeria Contamination in Food Samples 4
...
Standard 2" and 3" Fiberboard Boxes can be sold separately or with 16, 25, 36, 49, 64, 81 or 100 cell dividers. Fiberboard boxes can also be ordered with corresponding freezer racks...
Whole blood is collected from mice (Swiss Webster, 8-10 weeks old,either sex) and processed within 45 minutes of collection. The complement is then filtered and pooled on ice, bottled and stored at -...
... Immunogen : Recombinant human ... 5mg/ml BSA, 0.15M NaCl, 0.05% ... of glycerol to 30% Quality ... on acid extracts of murine ...
Biology Products: