Navigation Links
Silencing signals sent by parasite could aid sleeping sickness fight
Date:12/15/2013

A new discovery by scientists could help combat the spread of sleeping sickness.

Insights into how the parasites that cause the disease are able to communicate with one another could help limit the spread of the infection.

The findings suggest that new drugs could be designed to disrupt the flow of messages sent between these infectious microorganisms.

Sleeping sickness so named because it disrupts sleep patterns is transmitted by the bite of the tsetse fly, and more than 69 million people in Africa are at risk of infection. Untreated, it can damage the nervous system, leading to coma, organ failure and death.

During infection, the parasites known as African trypanosomes multiply in the bloodstream and communicate with each other by releasing a small molecule. When levels of this molecule become sufficiently high, this acts as a signal for the parasites to stop replicating and to change into a form that can be picked up by biting flies and spread.

A team led by researchers at the University of Edinburgh were able to uncover key components of the parasites' messaging system. They used a technique known as gene silencing, to identify those genes that are used to respond to the communication signals and the mechanisms involved.

Professor Keith Matthews, of the University of Edinburgh's School of Biological Sciences, who led the research, said: "Parasites are adept at communicating with one another to promote their survival in our bodies and ensure their spread but by manipulating their messages, new ways to combat these infections are likely to emerge."

The research, carried out in collaboration with the University of Dundee, was published in the journal Nature, and funded by the Wellcome Trust.


'/>"/>

Contact: Catriona Kelly
Catriona.Kelly@ed.ac.uk
44-131-651-4401
University of Edinburgh
Source:Eurekalert  

Page: 1

Related biology news :

1. Gene-silencing data now publicly available to help scientists better understand disease
2. Gene-silencing study finds new targets for Parkinsons disease
3. First-in-man study demonstrates the therapeutic effect of RNAi gene silencing in cancer treatment
4. CSHL researchers solve structure of human protein critical for silencing genes
5. Plant research reveals new role for gene silencing protein
6. A powder to enhance NMR signals
7. How living cells solved a needle in a haystack problem to produce electrical signals
8. Artifact suppression and analysis of brain activities with EEG signals
9. Neurochemical traffic signals may open new avenues for the treatment of schizophrenia
10. Researchers discover a missing link in signals contributing to neurodegeneration
11. Social bees mark dangerous flowers with chemical signals
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Silencing signals sent by parasite could aid sleeping sickness fight
(Date:4/18/2017)... , April 18, 2017  Socionext Inc., a global expert in ... media edge server, the M820, which features the company,s hybrid codec ... provided by Tera Probe, Inc., will be showcased during the upcoming ... NAB show at the Las Vegas Convention ... Click ...
(Date:4/13/2017)... According to a new market research report "Consumer ... Administration, and Authorization), Service, Authentication Type, Deployment Mode, Vertical, and Region - ... to grow from USD 14.30 Billion in 2017 to USD 31.75 Billion ... ... MarketsandMarkets Logo ...
(Date:4/11/2017)... 11, 2017 No two people are ... the New York University Tandon School of Engineering ... found that partial similarities between prints are common ... mobile phones and other electronic devices can be ... vulnerability lies in the fact that fingerprint-based authentication ...
Breaking Biology News(10 mins):
(Date:5/23/2017)... ... , ... Vortex Biosciences , provider of circulating tumor cell (CTC) capture ... using Vortex microfluidic technology ” in Nature Precision Oncology on May 8th. The ... and Dr. Matthew Rettig at the University of California, Los Angeles. The publication describes ...
(Date:5/23/2017)... Philadelphia, PA. (PRWEB) , ... May 23, 2017 ... ... Clinical Works as Vice President of Clinical Operations. She brings years ... Pharmaceuticals, and Yaupon Therapeutics. From her professional foundation as a licensed occupational therapist, ...
(Date:5/23/2017)... ... ... Cambridge Semantics , the leading provider of Big Data management and analytics ... in Boston May 23-25 with a featured speaker and solution demos of its ... also a finalist for the Best of Show award. , James LaPointe, Managing Director ...
(Date:5/22/2017)... ... May 22, 2017 , ... Stratevi, a boutique firm that partners with healthcare ... has opened an office in downtown Boston at 745 Atlantic Ave. , “We ... to generate evidence on the value they provide, not just to patients, but also ...
Breaking Biology Technology: