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Significant weight-loss from surgery decreases risk for cardiovascular disease in women
Date:9/16/2010

Significant weight loss not only improves daily life of morbidly obese woman but also decreases the risk for cardiovascular disease (CVD). However, many people can not lose weight or can not maintain weight loss without help. Bariatric surgery is emerging as a valuable procedure to help morbidly obese individuals lose weight, as studies have shown; it can improve many health profiles and lower mortality. Now, researchers have found another positive impact of significant weight loss after bariatric surgery: it can significantly improve the lipoprotein profiles of women within a year following surgery. This study, conducted by a team of scientists from Tufts University, the University of California-Davis and Oregon Health and Sciences Center, appears in the August Journal of Lipid Research.

Bariatric surgical procedures, such as gastric bypass surgery, have been shown to be an effective intervention to help individuals with morbid obesity lose weight and maintain the loss. Studies on people who have undergone the procedure have found that in addition to facilitating physical weight loss and lowering body fat, bariatric surgery also improves other health parameters, including heart rate, hypertension, and insulin sensitivity, and often result in resolution of type 2 diabetes.

Another area that is correlated with obesity and is a significant heart disease risk is the concentration of lipoproteins the cholesterol-containing LDL/HDL and related moleculesin the blood.

However, the effect of bariatric surgery on key lipoprotein markers for CVD has not been thoroughly investigated.

So, Bela Asztalos at Tufts' Human Nutrition Research Center and his colleagues analyzed the plasma samples for a number of lipids and lipoproteins and other markers for CVD in 19 obese female volunteers who underwent gastric bypass surgery prior to and after one year following surgery, as well as in samples from19 age-matched lean female control
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Contact: Nick Zagorski
nzagorski@asbmb.org
301-634-7366
American Society for Biochemistry and Molecular Biology
Source:Eurekalert

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