Navigation Links
Significant weight-loss from surgery decreases risk for cardiovascular disease in women
Date:9/16/2010

Significant weight loss not only improves daily life of morbidly obese woman but also decreases the risk for cardiovascular disease (CVD). However, many people can not lose weight or can not maintain weight loss without help. Bariatric surgery is emerging as a valuable procedure to help morbidly obese individuals lose weight, as studies have shown; it can improve many health profiles and lower mortality. Now, researchers have found another positive impact of significant weight loss after bariatric surgery: it can significantly improve the lipoprotein profiles of women within a year following surgery. This study, conducted by a team of scientists from Tufts University, the University of California-Davis and Oregon Health and Sciences Center, appears in the August Journal of Lipid Research.

Bariatric surgical procedures, such as gastric bypass surgery, have been shown to be an effective intervention to help individuals with morbid obesity lose weight and maintain the loss. Studies on people who have undergone the procedure have found that in addition to facilitating physical weight loss and lowering body fat, bariatric surgery also improves other health parameters, including heart rate, hypertension, and insulin sensitivity, and often result in resolution of type 2 diabetes.

Another area that is correlated with obesity and is a significant heart disease risk is the concentration of lipoproteins the cholesterol-containing LDL/HDL and related moleculesin the blood.

However, the effect of bariatric surgery on key lipoprotein markers for CVD has not been thoroughly investigated.

So, Bela Asztalos at Tufts' Human Nutrition Research Center and his colleagues analyzed the plasma samples for a number of lipids and lipoproteins and other markers for CVD in 19 obese female volunteers who underwent gastric bypass surgery prior to and after one year following surgery, as well as in samples from19 age-matched lean female control subjects. As expected, the baseline concentrations of triglycerides, glucose and insulin were significantly higher in obese than in normal-weight women, whereas HDL-cholesterol and apolipoprotein A-I levels were significantly lower.

Following an initial reduction of HDL at one month post surgery, most likely resulting from an early marked negative energy balance, plasma lipids and lipoproteins changed beneficially over the course of the year. Eventually they showed significant improvements comparable to individuals taking statin drugs (concentration of total HDL C increased by nearly 25% while the large, cholesterol-rich α-1 HDL particles, inversely associated with risk for CVD in previous studies, increased by as much as 177% over baseline levels). These increases coincided with reductions in body mass index, body adiposity, plasma triglycerides, and the LDL/HDL ratio. It is worth noting that the improvements of the HDL profile were significantly correlated with the improvements in glucose homeostasis indicating that lipid and glucose metabolisms are closely linked.

The authors note this initial investigation into the effects of weight loss/bariatric surgery on HDL remodeling does have some limitations, including that the observed improvements may not be applicable to men without further studies in male patients. Neither did the study track post-surgery diet, exercise and alcohol intake. However, this study does seem to indicate that beyond the decreases of body weight and fat mass, and the known beneficial effects on insulin sensitivity and glucose metabolism, weight loss/bariatric surgery can improve a number of lipid parameters associated with cardiovascular health and decreased risk for CVD in these weight-reduced patients.


'/>"/>

Contact: Nick Zagorski
nzagorski@asbmb.org
301-634-7366
American Society for Biochemistry and Molecular Biology
Source:Eurekalert

Related biology news :

1. New studies find global warming will have significant economic impacts on Florida coasts
2. Greenhouse gas auction revenues can help cut Md. electric use significantly, says study
3. Annual Bibliography of Significant Advances in Dietary Supplement Research 2007
4. Men with wives, significant others more likely to be screened for prostate cancer
5. Long-term use of diabetes drugs by women significantly increases risk of fractures
6. More accurate FEMA flood maps could help avoid significant damages and losses
7. New data suggest jumping genes play a significant role in gene regulatory networks
8. Rett Syndrome Research Trust advisor makes significant discovery
9. Salient Stills Notches Significant Advances in Profitability, Diversity of Sales and Customers, and Video Forensics Technology in 2008
10. In the warming West, climate most significant factor in fanning wildfires flames
11. Brain malformations significantly associated with preterm birth, Wake Forest research shows
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/30/2017)... -- On April 6-7, 2017, Sequencing.com will host the world,s ... at Microsoft,s headquarters in Redmond, Washington ... health and wellness apps that provide a unique, personalized ... is the first hackathon for personal genomics and the ... the genomics, tech and health industries are sending teams ...
(Date:3/30/2017)... NEW YORK , March 30, 2017 ... by type (physiological and behavioral), by technology (fingerprint, AFIS, ... recognition, voice recognition, and others), by end use industry ... travel and immigration, financial and banking, and others), and ... Europe , Asia Pacific ...
(Date:3/28/2017)... India , March 28, 2017 ... IP, Biometrics), Hardware (Camera, Monitors, Servers, Storage Devices), Software ... Vertical, and Region - Global Forecast to 2022", published ... Billion in 2016 and is projected to reach USD ... between 2017 and 2022. The base year considered for ...
Breaking Biology News(10 mins):
(Date:4/19/2017)... ... 19, 2017 , ... ThermaGenix, the PCR Improvement Company, announces ... several other early achievements at ThermaGenix, including the business formation and licensing agreements, ... will use proceeds from the Series A-1 round to:, , ...
(Date:4/19/2017)... ... April 19, 2017 , ... As part of the ... to novices as well as experienced users, attendees will gain a better understanding ... tests. , Hemostasis testing quality is determined by preanalytical variables which encompass ...
(Date:4/19/2017)... Calif. , April 19, 2017  As ... Drug Abuse and Heroin Summit ,  Proove┬« Biosciences, ... study analyzing genetics, environmental, and lifestyle factors to ... from the University of Southern California (USC), the ... , and Proove publish results showing that Proove ...
(Date:4/19/2017)... Calif. , April 19, 2017 ... ) today announced that it will report its ... market on Wednesday, May 3, 2017. Following the announcement, Veracyte,s management ... at 4:30 p.m. Eastern Time to discuss the company,s financial ... webcast and subsequent replay may be accessed by ...
Breaking Biology Technology: