Navigation Links
Significant findings about protein architecture may aid in drug design, generation of nanomaterials
Date:4/9/2010

Researchers in Singapore are reporting this week that they have gleaned key insights into the architecture of a protein that controls iron levels in almost all organisms. Their study culminated in one of the first successful attempts to take apart a complex biological nanostructure and isolate the rules that govern its natural formation.

The Nanyang Technological University team's work on the protein ferritin, the results of which appear in this week's issue of the Journal of Biological Chemistry, is expected to have significant ramifications on the fields of drug design and nanomaterials.

"Engineering the structure of a protein is one of the ultimate dreams of structural biologists," wrote one of the journal's peer reviewers, "and approaching that dream is greatly enabled through studies aimed at finding out what governs the nanoarchitecture of the protein."

Brendan P. Orner, the assistant professor who oversaw the team's work, described the protein ferritin as a potential model for explaining complicated protein structure in general.

Across the biological kingdoms, ferritin regulates the distribution of iron, which is necessary for a number of cellular functions but also forms reactive ions that can be lethal to cells. Shaped like a spherical nanocage, ferritin is made up of 24 proteins, and it sequesters the reactive iron ions in its hollow interior. In humans, ferritin prevents iron deficiency and overload.

"The rules that govern self-assembling nanosystems, like the ferritin model, are poorly understood," Orner explained. "We systematically analyzed the interactions between the 24 ferritin units that make up the nanocage and identified the hot spots that are crucial to the cage's formation."

Their goal was to discover which amino acids are responsible for assembling the cage, and they found that it is possible to both disassemble ferritin by removing single side chains of amino acids and,
'/>"/>

Contact: Angela Hopp
ahopp@asbmb.org
301-634-7389
American Society for Biochemistry and Molecular Biology
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Increase in ethanol production from corn could significantly impact
2. Endobronchial valve significantly improves emphysema
3. New Actemra data shows significant benefit for patients suffering from rheumatoid arthritis
4. Columbia researchers: Growth of CT scan use may lead to significant public health problem
5. Stanford researchers say climate change will significantly increase impending bird extinctions
6. M2SYS Introduces Revolutionary Biometric Artificial Intelligence Technology to Significantly Reduce Fingerprint Software False Reject Rates
7. Streams remove significant amounts of nitrogen, preventing downstream dead zones
8. New type of drug shrinks primary breast cancer tumors significantly in just 6 weeks
9. In computer models and observations, researchers see potential for significant red tide season
10. LIAI researchers discover new cellular mechanism that will significantly advance vaccine development
11. Climate change causing significant shift in composition of coastal fish communities
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Significant findings about protein architecture may aid in drug design, generation of nanomaterials
(Date:9/18/2014)... September 18, 2014 New research into the Crimean-Congo ... a severe hemorrhagic disease in humans similar to that ... for CCHFV infection. This discovery has the potential to ... pathogen. , The research, reported in a ... and conducted by scientists at the Texas Biomedical ...
(Date:9/18/2014)... International Space Station ever starts a "frequent flyers" program, ... Recently the orbiting laboratory has hosted increasing numbers of ... from the space station in April, and another is ... experiment is planned to launch in December. , Fruit ... the world-- and in space. Model organisms can reveal ...
(Date:9/18/2014)... spoken language is unique to humans. "The genetic changes ... human evolution to make this possible are largely unknown, ... have," says Wolfgang Enard, Professor of Anthropology and Human ... molecular biological basis of language Enard has now taken ... study, undertaken in collaboration with scientists at several universities, ...
Breaking Biology News(10 mins):Research milestone in CCHF virus could help identify new treatments 2Buzzing with activity: Fruit flies orbit Earth for science 2Buzzing with activity: Fruit flies orbit Earth for science 3Buzzing with activity: Fruit flies orbit Earth for science 4Language evolution: Quicker on the uptake 2Language evolution: Quicker on the uptake 3
... 2010 IDenta Corp.,(PINKSHEETS: IDTA) CEO Yaacov Shoham today issued a statement concerning the,BTK-Bullet hole test ... The IDenta,s BTK- Bullet Hole Testing Kit was mentioned in news articles,on the ... To see the article, click on the ... http://www.lasvegassun.com/news/2008/jul/08/gee-whiz-packed-metro-csi-tru , , ...
... July 6, 2010 A new computer data compression ... Research Institute (TGen), will allow genetic researchers and others to ... space and at lower cost. Created specifically for genomic ... use are described in a paper published today in the ...
... known as quantum dots make ideal tools for distinguishing ... and Georgia Tech scientists have demonstrated. An article ... 15 issue of Analytical Chemistry describes how ... Reed-Sternberg cells that are characteristic of Hodgkin,s lymphoma. ...
Cached Biology News:International Drug & Explosives Detection Company IDenta Corp Reports on BTK- Bullet Hole Testing Kit 2International Drug & Explosives Detection Company IDenta Corp Reports on BTK- Bullet Hole Testing Kit 3New TGen technology reduces storage needs and costs for genomic data 2New TGen technology reduces storage needs and costs for genomic data 3Multicolor quantum dots aid in cancer biopsy diagnosis 2
(Date:9/18/2014)... September 18, 2014 ... http://www.researchandmarkets.com/research/czvg3s/biocompatible ) has announced the addition ... Global Strategic Business Report" report ... ,This report analyzes the worldwide markets ... by the following Product Segments: Polymeric ...
(Date:9/18/2014)... , Sept. 18, 2014 Research and ... "Global and Chinese Stem Cell Industry Report, 2014-2017" ... are undifferentiated biological cells that can differentiate into specialized ... stem cells. Stem cell therapy can be applied to ... system disease), nervous system diseases, damage or lesion of ...
(Date:9/18/2014)... Sept. 18, 2014 Research and Markets ... Companion Diagnostics (Polymerase Chain Reaction, In-situ hybridization, Immunohistochemistry) Market ... their offering. The global companion diagnostics ... 22.7% from 2014 to 2019. Factors such as rising ... of companion diagnostics by the pharmaceutical industry, support from ...
(Date:9/18/2014)...  MEI Pharma, Inc. (Nasdaq: MEIP ), an ... for cancer, announced today that Daniel P. Gold , ... NewsMakers in the Biotech Industry conference on Friday, ... Millennium Broadway Hotel & Conference Center in New ... be accessed at www.meipharma.com . A replay will be ...
Breaking Biology Technology:Biocompatible Materials - Global Strategic Business Report 2014 2Biocompatible Materials - Global Strategic Business Report 2014 3Global and Chinese Stem Cell Industry Report, 2014-2017 2Global and Chinese Stem Cell Industry Report, 2014-2017 3Global Companion Diagnostics (Polymerase Chain Reaction, In-situ hybridization, Immunohistochemistry) Market - Trends & Forecasts to 2019 2Global Companion Diagnostics (Polymerase Chain Reaction, In-situ hybridization, Immunohistochemistry) Market - Trends & Forecasts to 2019 3MEI Pharma To Present At BioCentury's NewsMakers Conference 2MEI Pharma To Present At BioCentury's NewsMakers Conference 3
... one of the rapidly growing markets in life science field. By ... to reach $2.2 billion. Major factors that continue to affect the ... and emerging technologies. , ... San Jose, CA (PRWEB) ...
... at it, the notion of harvesting energy from the sun ... ever. , Researchers at Rensselaer Polytechnic Institute have discovered and ... solar energy. By developing a new antireflective coating that boosts ... those panels to absorb the entire solar spectrum from nearly ...
... 3 Amgen (Nasdaq:,AMGN) today announced that it ... 7, 2008 at the Millennium Broadway Hotel, 145 ... a.m. Eastern Time. Participating in,the meeting will be ... Ph.D., executive vice president, Research and Development, George,Morrow, ...
Cached Biology Technology:World Gene Amplification Technologies Market to Reach $2.2 Billion by 2015, According to New Report by Global Industry Analysts, Inc. 2World Gene Amplification Technologies Market to Reach $2.2 Billion by 2015, According to New Report by Global Industry Analysts, Inc. 3Solar power game-changer: 'Near perfect' absorption of sunlight, from all angles 2Solar power game-changer: 'Near perfect' absorption of sunlight, from all angles 3Amgen to Webcast 2008 Business Review Meeting on November 7 From Millennium Hotel in New York 2
Mouse monoclonal [BC-4] to Aggrecan xxPEN ( Abpromise for all tested applications). entrezGeneID: 176 SwissProtID: P16112...
7G10 anti-Fasciclin III...
Rabbit polyclonal to P5 ( Abpromise for all tested applications). entrezGeneID: 10954 SwissProtID: Q14554...
Goat polyclonal to HA1 ( Abpromise for all tested applications). Antigen: Synthetic peptide: TLGSCRERQPEFV from the C terminus of human HA1. Entrez GeneID: 23526 Swiss Protein ID: O78181...
Biology Products: