Navigation Links
Signaling pathway is 'executive software' of airway stem cells
Date:6/20/2011

DURHAM, NC Researchers at Duke University Medical Center have found out how mouse basal cells that line airways "decide" to become one of two types of cells that assist in airway-clearing duties. The findings could help provide new therapies for either blocked or thinned airways.

"Our work has identified the Notch signaling pathway as a central regulatory 'switch' that controls the differentiation of airway basal stem cells," said Jason Rock, Ph.D., lead author and postdoctoral researcher in Brigid Hogan's cell biology laboratory. "Studies like ours will enhance efforts to develop effective genetic, cellular, and molecular therapies for airway diseases - a leading cause of death worldwide."

The work was published in Cell Stem Cell on June 3.

Together with the current findings, recent studies suggest that the Notch signaling pathway represents a potential therapeutic target for airway remodeling and lung disease, he said.

"Notch is like an executive software package that helps to maintain the delicate balance of the epithelium, the lining of the airway," said senior author Brigid Hogan, Ph.D., chair of the Duke Department of Cell Biology. "The Notch pathway plays a role in other parts of the body, including neural stem cells, and this is the first time we have seen the results of the Notch pathway in airways. We have also found that the function of Notch signaling is conserved in basal cells from human airways."

Notch signaling dictates whether the daughters of basal stem cells assume one of two different fates, Hogan said. Sustained, high levels of Notch pathway activation result in more secretory cells. These make the needed amount of mucus to move out particles that need to be cleared. Low levels of Notch signal lead to ciliated cells, which act as brushes to move the mucus along toward clearance. Notch, however, isn't required for basal stem cells to proliferate and make additional basal cell daughters.

Airway disease, including chronic obstructive pulmonary disease, cystic fibrosis, asthma, acute allergies, and transplant complications, can range from fatal to debilitating, so understanding the secrets of how healthy cells can grow, and in the proper amounts, after injury is important. Fifty-five percent of deaths from lung disease result from changes in the small airways, Hogan said.

The researchers also demonstrated in this work that the smallest airway branches in humans are the same size and are organized like the largest (tracheal) airway tubes in mice.

The next step for the team is to investigate the behavior of the daughters of basal cells to learn what machinery is involved in making them commit to various lineages, and how this system is coordinated to help restore lung function, Hogan said.


'/>"/>

Contact: Mary Jane Gore
mary.gore@duke.edu
919-660-1309
Duke University Medical Center
Source:Eurekalert

Related biology news :

1. Study reveals important aspects of signaling across cell membranes in plants
2. Experimental drug inhibits cell signaling pathway and slows ovarian cancer growth
3. A new signaling pathway of the immune system is elucidated
4. Signaling path in brain may prevent that Im full message, UT Southwestern scientists discover
5. Nailing down a crucial plant signaling system
6. Carnegie Mellon researchers discover mechanism for signaling receptor recycling
7. Microfluidics-imaging platform detects cancer growth signaling in minute biopsy samples
8. Protein provides link between calcium signaling in excitable and non-excitable cells
9. Inhibiting cell signaling pathway may improve bone marrow transplant success rate
10. Investigators discover a new hot spot for the genesis of signaling neurons in the adult brain
11. New molecular signaling cascade increases glucose uptake
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/15/2016)... 2016 Research and Markets has ... Market 2016-2020,"  report to their offering.  , ... ,The global gait biometrics market is expected to ... period 2016-2020. Gait analysis generates multiple ... used to compute factors that are not or ...
(Date:3/31/2016)... 31, 2016   ... the "Company") LegacyXChange is excited to release ... soon to be launched online site for trading 100% ... ) will also provide potential shareholders a sense of ... to an industry that is notorious for fraud. The ...
(Date:3/23/2016)... WAKEFIELD, Massachusetts , March 23, 2016 ... kombiniert im Interesse erhöhter Sicherheit Gesichts- und ... Xura, Inc. (NASDAQ: MESG ... heute bekannt, dass das Unternehmen mit SpeechPro ... insbesondere aus der Finanzdienstleistungsbranche, wird die Möglichkeit ...
Breaking Biology News(10 mins):
(Date:5/24/2016)... ... , ... Last week, Callan Capital, an integrated wealth management firm specializing in ... San Diego Life Science event at the Estancia La Jolla Resort and Spa. , ... speakers Dr. Rich Heyman, former CEO of Aragon and Seragon, and Faheem Hasnain, former ...
(Date:5/23/2016)... 2016 Zimmer Biomet Holdings, Inc. (NYSE and SIX: ... its Board of Directors has approved the payment of a ... 2016. The cash dividend of $0.24 per ... to stockholders of record as of the close of business ... to approval of the Board of Directors and may be ...
(Date:5/23/2016)... ... 23, 2016 , ... Foresight Institute , a leading ... for the 2015 Foresight Institute Feynman Prizes. , These prestigious prizes, named ... for experiment and the other for theory in nanotechnology. Prof. Markus J. Buehler, ...
(Date:5/20/2016)... ... May 20, 2016 , ... Korean researchers say Manumycin A triggers apoptosis, or ... way to treat the disease. Surviving Mesothelioma has just posted an article on the ... Korean institutions based their mesothelioma study on the fact the Manumycin A, a derivative ...
Breaking Biology Technology: