Navigation Links
Signaling pathway is 'executive software' of airway stem cells
Date:6/20/2011

DURHAM, NC Researchers at Duke University Medical Center have found out how mouse basal cells that line airways "decide" to become one of two types of cells that assist in airway-clearing duties. The findings could help provide new therapies for either blocked or thinned airways.

"Our work has identified the Notch signaling pathway as a central regulatory 'switch' that controls the differentiation of airway basal stem cells," said Jason Rock, Ph.D., lead author and postdoctoral researcher in Brigid Hogan's cell biology laboratory. "Studies like ours will enhance efforts to develop effective genetic, cellular, and molecular therapies for airway diseases - a leading cause of death worldwide."

The work was published in Cell Stem Cell on June 3.

Together with the current findings, recent studies suggest that the Notch signaling pathway represents a potential therapeutic target for airway remodeling and lung disease, he said.

"Notch is like an executive software package that helps to maintain the delicate balance of the epithelium, the lining of the airway," said senior author Brigid Hogan, Ph.D., chair of the Duke Department of Cell Biology. "The Notch pathway plays a role in other parts of the body, including neural stem cells, and this is the first time we have seen the results of the Notch pathway in airways. We have also found that the function of Notch signaling is conserved in basal cells from human airways."

Notch signaling dictates whether the daughters of basal stem cells assume one of two different fates, Hogan said. Sustained, high levels of Notch pathway activation result in more secretory cells. These make the needed amount of mucus to move out particles that need to be cleared. Low levels of Notch signal lead to ciliated cells, which act as brushes to move the mucus along toward clearance. Notch, however, isn't required for basal stem cells to proliferate and make additional basal cell daught
'/>"/>

Contact: Mary Jane Gore
mary.gore@duke.edu
919-660-1309
Duke University Medical Center
Source:Eurekalert

Page: 1 2

Related biology news :

1. Study reveals important aspects of signaling across cell membranes in plants
2. Experimental drug inhibits cell signaling pathway and slows ovarian cancer growth
3. A new signaling pathway of the immune system is elucidated
4. Signaling path in brain may prevent that Im full message, UT Southwestern scientists discover
5. Nailing down a crucial plant signaling system
6. Carnegie Mellon researchers discover mechanism for signaling receptor recycling
7. Microfluidics-imaging platform detects cancer growth signaling in minute biopsy samples
8. Protein provides link between calcium signaling in excitable and non-excitable cells
9. Inhibiting cell signaling pathway may improve bone marrow transplant success rate
10. Investigators discover a new hot spot for the genesis of signaling neurons in the adult brain
11. New molecular signaling cascade increases glucose uptake
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/24/2015)... , Mar. 24, 2015 Research and Markets ... of the "Global Iris Recognition Market 2015-2019" ... the Global Iris Recognition market to grow at a ... This report covers the present scenario and the ... the period 2015-2019. To calculate the market size, the ...
(Date:3/24/2015)... 24, 2015   Crossmatch ™, a leading ... that its U.are.U ® 4500 Fingerprint Readers ... Bros . to achieve PCI compliance for Point-of-Sale ... to the POS terminal, protecting the retailer and ... breaches. With one-third of worldwide ...
(Date:3/23/2015)... , March 23, 2015  In the 2014 fiscal ... case conviction losses. This figure accounts for a fraction ... to The Nilson Report, exceeds $11 billion globally. The ... after a crime has occurred. Investor Mark Saint ... expert Joe Paolella partnered to administer the ...
Breaking Biology News(10 mins):Global Iris Recognition Market 2015-2019 with 3M Cogent, Bioenable Technologies, Cross Match Technology, Iris ID Systems & Safran Dominating 2Crossmatch Fingerprint Readers Help Retailer Prevent Data Breaches at Point-of-Sale 2Polygraph Test Now Used to Protect Investors From Fraud 2Polygraph Test Now Used to Protect Investors From Fraud 3
... - A Purdue University study shows dairy has an advantage ... Connie Weaver, distinguished professor and head of the food and ... dry milk were longer, wider, more dense and stronger than ... carbonate is the most common form of calcium used in ...
... biologist Dr. Gary G. Borisy, director and CEO of ... The National Academy of Sciences (NAS), an honorific society ... The achievement, considered one of the highest honors in ... Academy,s 146th annual meeting in Washington, D.C. Dr. Borisy ...
... calve from the northern front of the Wilkins Ice Shelf ... follows the collapse three weeks ago of the ice bridge ... The ice bridge, which effectively formed a barrier pinning ... Shelf, collapsed on 5 April removing about 330 sq km ...
Cached Biology News:Purdue study finds dairy better for bones than calcium carbonate 2MBL director and CEO and cell biology pioneer Gary Borisy elected to National Academy of Sciences 2MBL director and CEO and cell biology pioneer Gary Borisy elected to National Academy of Sciences 3Satellite imagery shows fragile Wilkins Ice Shelf destabilized 2
(Date:4/23/2015)... Jose, California (PRWEB) April 23, 2015 ... Predictive diagnostics refer to a series of genetic ... as cystic fibrosis, Lou Gehrig's disease, Huntington's disease, ... in examining the gene composition and interaction in ... the disease as well as the response to ...
(Date:4/23/2015)... Proove Biosciences , a commercial ... to announce the launch of Proove Non-Opioid ... 62 genetic variations to predict good versus poor ... non-opioid pain medications, namely ibuprofen (brand name Advil, ... Xanax) and acetaminophen (brand name Tylenol). , ...
(Date:4/23/2015)... CA (PRWEB) April 23, 2015 Delpor, ... today announced that the United States Patent and Trademark ... Company’s NANOPOR™ technology. US Pat. No. ... Delpor’s microfabricated drug delivery device for the ... proprietary NANOPOR™ technology for the sustained (zero-order) release of ...
(Date:4/22/2015)... Today, DuPont announced it has ... microbiome discovery company. This acquisition will build on ... both seed and crop protection to discover and ... , “In 2014, the businesses in DuPont’s Agriculture, ... more than $1 billion in biological solutions across ...
Breaking Biology Technology:Increasing Disease Prevalence & Focus on Preventive Healthcare Drive the Predictive Diagnostics Market, According to a New Report by Global Industry Analysts, Inc. 2Increasing Disease Prevalence & Focus on Preventive Healthcare Drive the Predictive Diagnostics Market, According to a New Report by Global Industry Analysts, Inc. 3Proove Biosciences Launches World’s First Test to Predict Responders to Commonly Prescribed Non-Opioid Pain Medications 2Proove Biosciences Launches World’s First Test to Predict Responders to Commonly Prescribed Non-Opioid Pain Medications 3Delpor, Inc. Announces the Issuance of 2 New US Patents Based on its Nanopore Technology which Enables the Sustained Release of Drugs from a Small Implant Device 2Delpor, Inc. Announces the Issuance of 2 New US Patents Based on its Nanopore Technology which Enables the Sustained Release of Drugs from a Small Implant Device 3DuPont Acquires Taxon Biosciences, Inc. 2DuPont Acquires Taxon Biosciences, Inc. 3DuPont Acquires Taxon Biosciences, Inc. 4
... Draper Laboratory, in conjunction with the National Academy of Engineering (NAE), ... about the impact engineers have had on our daily lives, and ... awarded "Engineering,s Nobel" since 1989. , ... Cambridge, MA ...
... Inc. (Nasdaq: SVNT ) today announced the ... Vice President, Chief Financial Officer & Treasurer. Mr. ... Savient,s Chief Financial Officer, effective immediately. "We are ... Vice President of Corporate Finance and Controller, David will ...
... SAN DIEGO, Feb. 12 Volcano Corporation,(Nasdaq: ... sales of,products for the diagnosis and treatment of coronary ... participating in the Roth Capital Partners,21st Annual Growth Stock ... The presentation by Scott Huennekens, president and chief ...
Cached Biology Technology:New Educational Website Celebrates the Accomplishments of Engineers 2Savient Announces Appointment of David Gionco as Chief Financial Officer 2Savient Announces Appointment of David Gionco as Chief Financial Officer 3Savient Announces Appointment of David Gionco as Chief Financial Officer 4Volcano Corporation Presentation at Roth Capital Partners Conference to Be Webcast 2
Recommended for use as a cell culture substratum at 0.1-0.2 mg/cm 2 or 5-10 μl/cm 2 . Optimal concentration depends on cell type as well as the application or research objectives. Type B...
... The Eclipse is a state-of-the-art separation ... Fractionation (AFFF) technique. The Eclipse integrates easily ... DAWN, miniDAWN Tristar, as well as the ... size and molar mass distributions of the ...
... for determining the absolute count of CD34+ ... peripheral blood samples, and leukapheresis samples. These ... cell count and a total CD45 (leucocyte) ... use in the BD Procount progenitor cell ...
... Protein A and, until recently, no readily available ... purification. Standard methods for IgM purification generally are ... for removing all of the major impurities present ... Pierce has developed an easy-to-use affinity matrix and ...
Biology Products: