Navigation Links
Signaling path in brain may prevent that 'I'm full' message, UT Southwestern scientists discover
Date:3/1/2011

the pathway was blocked, the cells were no longer resistant to leptin.

"In the follow-up experiments, which we conducted in mice, we were able to induce leptin resistance simply by infusing activators of this pathway, further supporting our theory that this signaling pathway may contribute to leptin resistance in obesity," said Dr. Makoto Fukuda, instructor of internal medicine at UT Southwestern and the study's lead author.

Dr. Elmquist said that while the EPAC signaling pathway itself is not novel, this is the first time it has been studied in the hypothalamus and in the context of energy balance and leptin signaling.

The next step, Dr. Elmquist said, is to investigate how critical the EPAC pathway actually is in leptin responsive neurons and to determine its role in maintaining energy balance and leptin sensitivity.

"These results are potentially interesting and provocative, but the physiological importance remains to be seen," Dr. Elmquist said. "If, however, this pathway is indeed important, it will offer new insights into the mechanisms that high levels of leptin cause in leptin resistance."


'/>"/>

Contact: Kristen Holland Shear
kristen.hollandshear@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert

Page: 1 2

Related biology news :

1. Nailing down a crucial plant signaling system
2. Carnegie Mellon researchers discover mechanism for signaling receptor recycling
3. Microfluidics-imaging platform detects cancer growth signaling in minute biopsy samples
4. Protein provides link between calcium signaling in excitable and non-excitable cells
5. Inhibiting cell signaling pathway may improve bone marrow transplant success rate
6. Investigators discover a new hot spot for the genesis of signaling neurons in the adult brain
7. New molecular signaling cascade increases glucose uptake
8. Scientists post lower speed limit for cell-signaling protein assembly
9. Insulin signaling key to caste development in bees
10. Cell signaling classification system gives researchers new tool
11. New bacterial signaling molecule could lead to improved vaccines
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/27/2014)... data," a single computer cannot always find the solution ... across a cluster of computers that analyze a massive ... your web history to present you with targeted ads, ... book or movie. But big data is about more ... brain activity are generating unprecedented quantities of information. That ...
(Date:7/25/2014)... raging this summer and some of the smoke from those ... image collected by the Moderate Resolution Imaging Spectroradiometer (MODIS) aboard ... smoke has descended over the Great Lakes region of the ... image from July 23, 2014 (first image feature highlighted below) ... off southeastward. In the image, it is over Manitoba ...
(Date:7/25/2014)... consume the healthcare community and remain priority ... To address the worldwide crisis of obesity ... global leaders in diabetes, epidemiology and public ... and development of diverse intervention programs in ... This book on "Global Health Perspectives in ...
Breaking Biology News(10 mins):New tools help neuroscientists analyze 'big data' 2New tools help neuroscientists analyze 'big data' 3New tools help neuroscientists analyze 'big data' 4New tools help neuroscientists analyze 'big data' 5What constitutes an effective response to the global 'diabesity' tsunami? 2
... first used clinically, scientists can finally get a detailed, ... This receptor hails from a family of proteins called ... several of our senses, and the action of about ... known structure of a human GPCR, the work promises ...
... Researchers at Purdue and Duke universities have developed ... selectively separate tiny magnetic particles, representing a highly ... samples from patients. Because different pathogens could ... new technique can selectively separate particles by size, ...
... concludes that increasing levels of ozone due to the ... resulting in serious costs to the world,s economy. ... Energy Policy, focused on how three environmental changes (increases ... activity will affect crops, pastures, and forests. ...
Cached Biology News:Scientists unveil structure of molecular target of many drugs 2New system would use rotating magnetic field to detect pathogens 2New system would use rotating magnetic field to detect pathogens 3New system would use rotating magnetic field to detect pathogens 4MIT: Human-generated ozone will damage crops 2MIT: Human-generated ozone will damage crops 3
(Date:7/28/2014)... MADISON, Wis. , July 28, 2014   ... chronic respiratory disease, announced the hire of Brad ... Development. Towle will be responsible for driving the company,s ... "Brad,s broad experience in healthcare, and specifically his past ... valuable insight to the company at this pivotal time ...
(Date:7/28/2014)... 2014  InterMune, Inc. (NASDAQ: ITMN ) ... 2014 financial results at the close of the U.S. ... and webcast will be hosted by InterMune at 4:30 ... investors and others may participate in the conference call ... ID#21728775. A replay of the webcast and teleconference will be ...
(Date:7/26/2014)... Canada Endoscopy Visualization Systems Market ... the Canada Endoscopy Visualization Systems market. The report ... (in units) and average prices (in US dollars) ... Mid-Range Endoscopy Visualization Systems and Low-End Endoscopy Visualization ... . , The report also provides company shares ...
(Date:7/25/2014)... from the University of Leicester has furthered our ... potential to create new materials using nanosized ,building ... in the prestigious academic journal Physical Review ... examine in rich detail the structure and internal ... acetylene molecule and a single helium atom. , ...
Breaking Biology Technology:Propeller Health Hires Brad Towle as Senior Vice President of Business and Client Development 2InterMune to Release Second Quarter Financial Results on August 6 2Canada Endoscopy Visualization Systems Market Outlook to 2020: MarketResearchReports.Biz 2Canada Endoscopy Visualization Systems Market Outlook to 2020: MarketResearchReports.Biz 3Canada Endoscopy Visualization Systems Market Outlook to 2020: MarketResearchReports.Biz 4Canada Endoscopy Visualization Systems Market Outlook to 2020: MarketResearchReports.Biz 5Breakthrough laser experiment reveals liquid-like motion of atoms in an ultra-cold cluster 2Breakthrough laser experiment reveals liquid-like motion of atoms in an ultra-cold cluster 3
... Sept. 30 DOR BioPharma, Inc. (OTC Bulletin Board: SNGX), ... a corporate name change from DOR BioPharma, Inc. to Soligenix, ... name change, the Company,s shares of common stock will immediately ... today. , "We are pleased to announce the ...
... 30 /PRNewswire-FirstCall/ - Quest PharmaTech Inc. (TSX-V: QPT) ... and commercializing products for the treatment of cancer, ... of late-stage immunotherapy product candidates from Paladin Labs ... candidates consists of five monoclonal antibodies targeting certain ...
... , ... application enables system access and security for federal employees, regardless of location , ... Miami, FL (PRWEB) September ... landmark partnership with the Ministry of Health in Spain, providing the agency with software-based ...
Cached Biology Technology:DOR BioPharma Announces Corporate Name Change to Soligenix and Begins Trading Under New Ticker Symbol 'SNGX' 2DOR BioPharma Announces Corporate Name Change to Soligenix and Begins Trading Under New Ticker Symbol 'SNGX' 3DOR BioPharma Announces Corporate Name Change to Soligenix and Begins Trading Under New Ticker Symbol 'SNGX' 4Quest PharmaTech Acquires Late-Stage Immunotherapeutic Antibody Pipeline 2Quest PharmaTech Acquires Late-Stage Immunotherapeutic Antibody Pipeline 3Quest PharmaTech Acquires Late-Stage Immunotherapeutic Antibody Pipeline 4Spain's Health Ministry Contracts Authenware to Fortify System Security Prior to Flu Season 2Spain's Health Ministry Contracts Authenware to Fortify System Security Prior to Flu Season 3
... Persistent Analysis Environment 2) Dot plot, ... 3) Software Compensation 4) Cell Cycle ... Platform 7) Intelligent batch generation of graphs ... 9) Single drag-and-drop operations to perform complex ...
Eagle's Ham's amino acids; EHAA...
... The proteomic service includes protein separation ... using the PDQuest software package from ... mass spectrometry. In order to meet ... preparation, data analysis and format of ...
... Leptin is a proteohormone with a molecular weight ... by the ob gene and produced by adipocytes [1,2]. ... in the regulation of body weight [1-3]. In ... in both men and women [4]. A relationship ...
Biology Products: