Navigation Links
Sibling study could lead to better treatments for inherited form of colon cancer
Date:11/3/2008

SALT LAKE CITYResearchers at Huntsman Cancer Institute (HCI) believe they may be one step closer to understanding how certain forms of colon cancer develop.

In a study using siblings who have been diagnosed with colon cancer, scientists discovered similarities on a region of a particular chromosome, referred to as 7q31. Researchers believe that piece of genetic material may be causing a subset of colon cancers that run in families.

"It's those genetic similarities in colon cancer patients that would suggest that region holds a gene that's causing colon cancer," says Deborah Neklason, PhD and lead investigator on the study. Referred to as the Cancer Genetics Network "Sibling Pair Project," Neklason and other researchers analyzed the genetic material of 82 siblings. In addition to the discovery of a potential location of a cancer-causing gene, the research also shows siblings who share this genetic region tend to develop cancer 3.8 years earlier than siblings who do not. The study findings are published in the November 1, 2008 issue of Cancer Research.

Scientists already know roughly 30 percent of all colon cancers are a direct result of an inherited gene, but less than five percent of these genes have been identified. "Those cases where the genes have been identified tend to be pretty dramatic," says Neklason. "Colon cancer develops at young ages and the cases are easier to figure out. It's the other 25 percent that's tough. These cases are more like sporadic colon cancer and are much more subtle," she says.

The findings could ultimately lead to a better understanding of the cellular process that results in cancer and its progression. It will likely pave the way for more targeted research that could someday result in a screening test to detect genetic forms of colon cancer.


'/>"/>

Contact: Kathy Wilets
kathy.wilets@hci.utah.edu
801-587-4770
University of Utah Health Sciences
Source:Eurekalert

Page: 1

Related biology news :

1. High hormone levels in seabird chicks prepare them to kill their siblings
2. Nature study demonstrates that bacterial clotting depends on clustering
3. Study sheds light on genetic differences that cause a childhood eye disease
4. Grapes may aid a bunch of heart risk factors, animal study finds
5. Study confirms amphibians ability to predict changes in biodiversity
6. Study rules out inbreeding as cause of amphibian deformities
7. Researchers apply systems biology and glycomics to study human inflammatory diseases
8. Study helps clarify role of soil microbes in global warming
9. Franklin Square to study airway bypass procedure for severe emphysema
10. Study may explain exercise-induced fatigue in muscular dystrophies
11. First comprehensive genomic study of common cold reveals new treatment targets
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/19/2014)... from several Harvard University labs in collaboration with ... researchers with the intellectual raw materials needed to ... flexible materials. , With the advent of low-cost ... manufacturing technology, soft robotics is emerging as an ... rigid robot design, but working with pliable materials, ...
(Date:9/19/2014)... University of Oklahoma biology professor will study multifunctional ... leg movements with a National Science Foundation grant ... project. , Ari Berkowitz, professor in the Department ... will focus on the differences between the multifunctional ... what neurotransmitters they use and what connections they ...
(Date:9/19/2014)... are a species which over thousands of years has adapted ... a substance that makes the cold dangerous for you. , ... albidus , and the cold provoking substance, called nonylphenol, comes ... Nonylphenol is suspected of being a endocrine disruptor, but when ... the worm,s ability to protect the cells in its body ...
Breaking Biology News(10 mins):Soft robotics 'toolkit' features everything a robot-maker needs 2Environmental pollutants make worms susceptible to cold 2Environmental pollutants make worms susceptible to cold 3
... the movement and population size changes of Kiwis, Tuatara and ... been continually studied by conservationists and scientists. It now seems ... infect them. , Dr Alexei Drummond, from The University ... global research team analysing the genetic sequences of viruses in ...
... a Senior Research Associate at the Stowers Institute for ... and an investigator with the Howard Hughes Medical Institute, ... called Snail is expressed in a cyclic fashion during ... and chick embryo. , The findings, which were ...
... been well documented that, across human cultures and in most ... females. It's simple to blame male hormones, like testosterone, for ... genes, too. , Indeed such social behavior also has a ... at the University of Virginia Health System. "The differences ...
Cached Biology News:Finding a virus is not all bad news 2Stowers scientists demonstrate mechanism of vertebral formation 2Sex chromosome genes influence aggression andmaternal behavior, say UVa researchers 2
(Date:9/22/2014)... 2014 FierceBiotech today announced its annual ... companies of 2014. FierceBiotech editors John Carroll and ... year’s winners. Those selected are identified as some ... industry. , "It's always a lot of ... 15 companies," said Carroll. "This year in particular you'll ...
(Date:9/22/2014)... 2014  Spherix Incorporated (SPEX) -- an intellectual property development ... today announced that the United States Patent & Trademark Office ... month of September that is part of a standard essential ... USRE45,121 , Application number: US 13/728,867 , ... 27, 2012 The listed inventors of the ...
(Date:9/20/2014)... HealthTronics, Inc. , a leading ... and services, has signed a distribution agreement through ... for its high precision laser technology. ... mobile, surgical technology—offering more choices for healthcare providers ... will make available Clinicon’s FDA-cleared SureLase™ CO2 Laser ...
(Date:9/19/2014)... to move data would consume much less power ... as chips, transistor counts rise. , Of the ... emitters, modulators, and detectors emitters are the ... optical chips is molybdenum disulfide (MoS2), which has ... atom-thick layer. Other experimental on-chip light emitters have ...
Breaking Biology Technology:FierceBiotech Announces Annual “Fierce 15” Winners of 2014 2Spherix Notified by United States Patent & Trademark Office of New Standard Essential Patent Issued to Spherix 2Spherix Notified by United States Patent & Trademark Office of New Standard Essential Patent Issued to Spherix 3HealthTronics Announces Distribution Agreement with Clinicon-Laser Surgical Device Expands Minimally Invasive, Mobile Technology Portfolio 2HealthTronics Announces Distribution Agreement with Clinicon-Laser Surgical Device Expands Minimally Invasive, Mobile Technology Portfolio 3Toward optical chips 2Toward optical chips 3
... test aids in identifying connection between improved lipid profile ... Using the VAP Cholesterol Test from ... found an association between a rare gene mutation and ... could help in the development of heart disease risk-lowering ...
... field of electrospinning for applications primarily within the medical ... Inc. announces a new technology platform in the field ... thicknesses ranging from the nano to microscale. Zeus is ... pastes, and bioabsorbables. The result is a broad range ...
... help solve the world,s energy crisis? Probably not, ... its own small part to provide a new and ... nanotechnology, Georgia Institute of Technology researchers have also generated ... users of BlackBerry devices, cell phones and other handhelds ...
Cached Biology Technology:VAP Cholesterol Test Helps In Search For New Heart Disease Drugs 2VAP Cholesterol Test Helps In Search For New Heart Disease Drugs 3VAP Cholesterol Test Helps In Search For New Heart Disease Drugs 4Electrospinning: Emerging New Technology at Zeus 2Nanogenerators produce electricity from running rodents and tapping fingers 2Nanogenerators produce electricity from running rodents and tapping fingers 3
... Kits without ammonium sulfate are compatible with ... as Taq and AmpliThem™™ DNA polymerases. You ... systems in one experiment by adding your ... the PreMixes supplied with the kit. This ...
Special grade: for molecular biology Density: 1.000 g/mL (20 C)...
Matrix for protein MALDI-MS...
... is part of a series of media originally ... Weiss et al. for the large scale propagation ... medium is primarily used for the growth and ... the propagation of viruses in these cell lines. ...
Biology Products: