Navigation Links
Sibling study could lead to better treatments for inherited form of colon cancer
Date:11/3/2008

SALT LAKE CITYResearchers at Huntsman Cancer Institute (HCI) believe they may be one step closer to understanding how certain forms of colon cancer develop.

In a study using siblings who have been diagnosed with colon cancer, scientists discovered similarities on a region of a particular chromosome, referred to as 7q31. Researchers believe that piece of genetic material may be causing a subset of colon cancers that run in families.

"It's those genetic similarities in colon cancer patients that would suggest that region holds a gene that's causing colon cancer," says Deborah Neklason, PhD and lead investigator on the study. Referred to as the Cancer Genetics Network "Sibling Pair Project," Neklason and other researchers analyzed the genetic material of 82 siblings. In addition to the discovery of a potential location of a cancer-causing gene, the research also shows siblings who share this genetic region tend to develop cancer 3.8 years earlier than siblings who do not. The study findings are published in the November 1, 2008 issue of Cancer Research.

Scientists already know roughly 30 percent of all colon cancers are a direct result of an inherited gene, but less than five percent of these genes have been identified. "Those cases where the genes have been identified tend to be pretty dramatic," says Neklason. "Colon cancer develops at young ages and the cases are easier to figure out. It's the other 25 percent that's tough. These cases are more like sporadic colon cancer and are much more subtle," she says.

The findings could ultimately lead to a better understanding of the cellular process that results in cancer and its progression. It will likely pave the way for more targeted research that could someday result in a screening test to detect genetic forms of colon cancer.


'/>"/>

Contact: Kathy Wilets
kathy.wilets@hci.utah.edu
801-587-4770
University of Utah Health Sciences
Source:Eurekalert

Page: 1

Related biology news :

1. High hormone levels in seabird chicks prepare them to kill their siblings
2. Nature study demonstrates that bacterial clotting depends on clustering
3. Study sheds light on genetic differences that cause a childhood eye disease
4. Grapes may aid a bunch of heart risk factors, animal study finds
5. Study confirms amphibians ability to predict changes in biodiversity
6. Study rules out inbreeding as cause of amphibian deformities
7. Researchers apply systems biology and glycomics to study human inflammatory diseases
8. Study helps clarify role of soil microbes in global warming
9. Franklin Square to study airway bypass procedure for severe emphysema
10. Study may explain exercise-induced fatigue in muscular dystrophies
11. First comprehensive genomic study of common cold reveals new treatment targets
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/9/2016)... leader in attendance control systems is proud to announce the introduction of fingerprint attendance ... the right employees are actually signing in, and to even control the opening of ... ... ... Photo - ...
(Date:6/2/2016)... , June 2, 2016 The ... has awarded the 44 million US Dollar project, for ... Embossed Vehicle Plates including Personalization, Enrolment, and IT Infrastructure ... leader in the production and implementation of Identity Management Solutions. ... January, however Decatur was selected for ...
(Date:5/24/2016)... facilitates superior patient care by providing unparalleled technology to leaders of the medical imaging ... product recently added to the range of products distributed by Ampronix. Photo ... ... ... News ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... -- A person commits a crime, and the detective uses ... criminal down. An outbreak of foodborne illness makes ... uses DNA evidence to track down the bacteria that caused ... not. The FDA has increasingly used a complex, cutting-edge technology ... Put as simply as possible, whole genome sequencing is a ...
(Date:6/23/2016)...  The Prostate Cancer Foundation (PCF) is pleased to announce 24 ... for prostate cancer. Members of the Class of 2016 were selected from a ... Read More About the Class of 2016 PCF Young Investigators ... ... ...
(Date:6/23/2016)... (PRWEB) , ... June 23, 2016 , ... ... today announced the launch of the Supplyframe Design Lab . Located in ... to explore the future of how hardware projects are designed, built and brought ...
(Date:6/23/2016)... 2016 Apellis Pharmaceuticals, Inc. today announced ... of its complement C3 inhibitor, APL-2. The trials ... dose studies designed to assess the safety, tolerability, ... in healthy adult volunteers. Forty subjects ... single dose (ranging from 45 to 1,440mg) or ...
Breaking Biology Technology: