Navigation Links
Short DNA strands in the genome may be key to understanding human cognition and diseases
Date:11/21/2012

d to be "junk DNA" with no particular function.

Now, they present new leads on how the human brain has evolved, and a starting point for studying neurological diseases. For example, the sequence of DPP10a gene critically important for normal human brain developmentnot only showed distinct human-specific chromatin structures different from other primate brains such as the chimpanzee or the macaque, but the underlying DNA sequence showed some interesting differences from two extinct primatesthe Neanderthal and Denisovan, most closely related to our own species and also referred to as 'archaic hominins'.

"Many neurological disorders are unique to human and are very hard as a clinical syndrome to study in animals, such as Alzheimer's disease, autism, and depression," said Dr. Akbarian. "By studying epigenetics we can learn more about those unique pieces of the human genome."

The research team also discovered that several of these chromatin regions appear to physically interact with each other inside the cell nucleus, despite being separated by hundreds of thousands of DNA strands on the genome. This phenomenon of "chromatin looping" appears to control the expression of neighboring genes, including several with a critical role for human brain development.

"There is growing consensus among genome researchers that much of what was previously considered as 'junk sequences' in our genomes indeed could play some sort of regulatory role," said Dr. Akbarian.

This study was supported by grants from the National Institutes of Health. Dr. Akbarian plans to do more epigenetic studies in other areas of the brain to see if there are additional chromatin regions that are unique to humans. They also plan to study the epigenomes of other mammals with highly evolved social behaviors such as elephants.

Dr. Akbarian joined Mount Sinai in July 2012. He is internationally known for his cutting-edge research on the epigenetic mechani
'/>"/>

Contact: Mount Sinai Press Office
newsmedia@mssm.edu
212-241-9200
The Mount Sinai Hospital / Mount Sinai School of Medicine
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. The long, err, short of it
2. Glycogen accumulation in neurons causes brain damage and shortens the lives of flies and mice
3. New product to replace fishmeal could help prevent global food shortage
4. Reed Elsevier Environmental Challenge shortlists 2012 projects
5. Short stretches of piRNA evaluate cells genetic history
6. UC Davis study finds that above-normal weight alone does not increase the short-term risk of death
7. A shortcut to sustainable fisheries
8. Plants unpack winter coats when days get shorter
9. Bone marrow stem cells do not improve short-term recovery after heart attack
10. Leading evolutionary scientist to discuss how genome of bacteria has evolved
11. Darwin in the genome
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/25/2014)... consume the healthcare community and remain priority ... To address the worldwide crisis of obesity ... global leaders in diabetes, epidemiology and public ... and development of diverse intervention programs in ... This book on "Global Health Perspectives in ...
(Date:7/25/2014)... diffusion tensor tractography (DTT), which is derived from ... for three motor tracts, such as the corticospinal ... became possible. The corticospinal tract is known to ... in the human brain. Several studies have reported ... herniation. In addition, some studies have demonstrated recovery ...
(Date:7/25/2014)... have detected an unknown interaction between microorganisms and salt. ... a droplet of salt water and is left to ... biomineralogical biosaline 3D morphologically complex formations, where they hibernate. ... The discovery was made by chance with a home ... Astrobiology journal and may help to find signs ...
Breaking Biology News(10 mins):What constitutes an effective response to the global 'diabesity' tsunami? 2Bacteria manipulate salt to build shelters to hibernate 2
... 2, 2014 EcoHealth Alliance, a nonprofit organization ... issues, and Bat Conservation International, which works to ... are joining forces in formal partnership. The organizations ... and public health programs that enhance outreach with ...
... N.C. A new Duke University-led study has documented dramatic, ... estuary. "The natural short-term variability in acidity ... global predictions for the ocean as a whole and may ... organisms, particularly shelled organisms that are especially susceptible to changes ...
... centuries as a pain reliever in Chinese medicine may be ... chronic pain. A key pain-relieving ingredient is a compound known ... plant Corydalis , a member of the poppy family, ... Press journal Current Biology on January 2. ...
Cached Biology News:EcoHealth Alliance and Bat Conservation International forge partnership to work on global bat conservation and public health issues 2Local factors cause dramatic spikes in coastal ocean acidity 2Plant used in Chinese medicine fights chronic pain 2
(Date:7/25/2014)... York (PRWEB) July 25, 2014 According ... Research, "Biological Drugs Market - Global Industry Analysis, Size, ... global biological drugs market is estimated at USD 161,056.5 ... a CAGR of 10.1% from 2014 to 2020, to ... 2020. , The biological drugs market is witnessing a ...
(Date:7/25/2014)... The Conferee Networking committee is pleased to ... These two-hour sessions provide a unique networking opportunity for ... discuss new techniques, or brainstorm new ideas in an ... for consideration is August 31, 2014, and instructions can ... committee will review the topics, and status notifications will ...
(Date:7/25/2014)... , July 25, 2014  Galmed Pharmaceuticals Ltd. (Nasdaq: ... focused on the development and commercialization of a once-daily, ... cholesterol gallstones, today announced financial results for the period ... Financial Summary: , Reported cash and cash equivalents ... $137,000 at December 31, 2013.  , Reported a ...
(Date:7/25/2014)... July 25, 2014 At the request ... granted a 60-day extension for the public comment period ... Rule for Model Aircraft established by Congress as part ... The 60-day extension establishes the new deadline for comments ... Department of Transportation/FAA notice published in the Federal Register ...
Breaking Biology Technology:Biological Drugs Market: Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2014 - 2020 2Biological Drugs Market: Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2014 - 2020 3Pittcon 2015 Announces Call for Topics for Conferee Networking Sessions 2Galmed Pharmaceuticals Reports First Half 2014 Financial Results 2Galmed Pharmaceuticals Reports First Half 2014 Financial Results 3Galmed Pharmaceuticals Reports First Half 2014 Financial Results 4Galmed Pharmaceuticals Reports First Half 2014 Financial Results 5Galmed Pharmaceuticals Reports First Half 2014 Financial Results 6FAA Grants Comment Extension at the Request of AMA 2
... Biopharmaceuticals,Inc. (Nasdaq: KERX ) will hold a conference ... to discuss the Third Quarter 2007 financial results.,Michael S. ... will,host the call. Keryx will announce its financial results ... prior to the call. In order to participate ...
... Positive Phase I Results for R1507, COPENHAGEN, October ... from a Phase I study of R1507 in patients,with ... a human,monoclonal antibody targeting the insulin-like growth factor receptor,(IGF-1R) ... Nine of 34 adult patients with solid tumors experienced ...
... Calif., Oct. 23 InVitria has released ... factor for cell culture,media outperforms transferrin and ... Because Lacromin is produced in a completely,animal-free ... over,animal-derived alternatives including bovine and human transferrin. ...
Cached Biology Technology:Keryx Biopharmaceuticals, Inc. to Hold Conference Call on Third Quarter 2007 Financial Results on Thursday, October 25, at 8:30 A.M. EDT 2Phase I Results Announced for R1507 From Genmab's Collaboration With Roche 2Phase I Results Announced for R1507 From Genmab's Collaboration With Roche 3InVitria's Animal Free Lacromin(TM) Provides a Cost-Effective Improvement Over Transferrin 2
...
Request Info...
LECHNER AND LaVECK MEDIUMfor the clonal growth of normal human bronchial and other epithelial cells. Requires additives. With glutamine.Recommended storage condition:oC to 8oCIntended use(s):research...
The FliTrx Panning Kit is designed to simplify panning for protein-protein interactions with the FliTrx Random Peptide Display Library or the pFliTrx Peptide Display Vector....
Biology Products: