Navigation Links
Short DNA strands in the genome may be key to understanding human cognition and diseases
Date:11/21/2012

d to be "junk DNA" with no particular function.

Now, they present new leads on how the human brain has evolved, and a starting point for studying neurological diseases. For example, the sequence of DPP10a gene critically important for normal human brain developmentnot only showed distinct human-specific chromatin structures different from other primate brains such as the chimpanzee or the macaque, but the underlying DNA sequence showed some interesting differences from two extinct primatesthe Neanderthal and Denisovan, most closely related to our own species and also referred to as 'archaic hominins'.

"Many neurological disorders are unique to human and are very hard as a clinical syndrome to study in animals, such as Alzheimer's disease, autism, and depression," said Dr. Akbarian. "By studying epigenetics we can learn more about those unique pieces of the human genome."

The research team also discovered that several of these chromatin regions appear to physically interact with each other inside the cell nucleus, despite being separated by hundreds of thousands of DNA strands on the genome. This phenomenon of "chromatin looping" appears to control the expression of neighboring genes, including several with a critical role for human brain development.

"There is growing consensus among genome researchers that much of what was previously considered as 'junk sequences' in our genomes indeed could play some sort of regulatory role," said Dr. Akbarian.

This study was supported by grants from the National Institutes of Health. Dr. Akbarian plans to do more epigenetic studies in other areas of the brain to see if there are additional chromatin regions that are unique to humans. They also plan to study the epigenomes of other mammals with highly evolved social behaviors such as elephants.

Dr. Akbarian joined Mount Sinai in July 2012. He is internationally known for his cutting-edge research on the epigenetic mechani
'/>"/>

Contact: Mount Sinai Press Office
newsmedia@mssm.edu
212-241-9200
The Mount Sinai Hospital / Mount Sinai School of Medicine
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. The long, err, short of it
2. Glycogen accumulation in neurons causes brain damage and shortens the lives of flies and mice
3. New product to replace fishmeal could help prevent global food shortage
4. Reed Elsevier Environmental Challenge shortlists 2012 projects
5. Short stretches of piRNA evaluate cells genetic history
6. UC Davis study finds that above-normal weight alone does not increase the short-term risk of death
7. A shortcut to sustainable fisheries
8. Plants unpack winter coats when days get shorter
9. Bone marrow stem cells do not improve short-term recovery after heart attack
10. Leading evolutionary scientist to discuss how genome of bacteria has evolved
11. Darwin in the genome
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/27/2014)... that century-old museum specimens hold clues to how global climate ... and kill trees and the news is not good. ... oak and maple trees in warmer urban areas, which raises ... warming," says Dr. Elsa Youngsteadt, a research associate at NC ... , "More scale insects would be a problem, since scales ...
(Date:8/26/2014)... Scientists at the University of Warwick have provided ... naturally occurring protein is linked to early signs ... , the research found that the absence of ... to cells in the nervous system. These changes ... early signs of dementia, including restricted learning and ...
(Date:8/26/2014)... of a pen a New Zealand endemic tree has for ... a group of ,weedy, Australian shrubs and small trees. A ... some surprises and discover astonishing cryptic diversity behind what was ... in the open access journal PhytoKeys . ... species was one of the many discoveries made in the ...
Breaking Biology News(10 mins):Museum specimens, modern cities show how an insect pest will respond to climate change 2Lack of naturally occuring protein linked to dementia 2And then there were 10 -- unexpected diversity in New Zealand kanuka genus Kunzea 2And then there were 10 -- unexpected diversity in New Zealand kanuka genus Kunzea 3
... BLOOMINGTON, Ind. -- Two recently diverged populations of a ... contribute to the reproductive isolation that accompanies the origin ... of organic compounds present in the preen oils of ... Ecology . "There,s so much we don,t know ...
... Age and gender play a major role in how ... 20-to-64-year-olds. Published in the journal Psychophysiology , the investigation ... the Montreal Heart Institute in collaboration with colleagues from the ... findings suggest that women who are more defensive are at ...
... University of Western Ontario finds the sauces you use when ... benefits. The research, led by Western biology and psychology ... than just tasty sauces they can also provide a ... Mark Bernards and Christopher Guglielmo in Western,s department of biology. ...
Cached Biology News:Could smell play a role in the origin of new bird species? 2Could smell play a role in the origin of new bird species? 3Men and women respond differently to stress 2Spice up your health this barbecue season 2
(Date:8/27/2014)... 2014 After the boom of the ... next beverage craze is going to be the stress ... can use Stress Relief energy pattern which can be ... of a beverage, including minerals, herbs and liquids. Stress ... that power into rapid recovery and helping to adapt ...
(Date:8/27/2014)... WriteResult, LLC – a premier provider of ePRO ... when it comes to meeting the needs of a ... their most recent study closeout on-time and with near ... writing platform to collect Patient Reported Outcomes electronically for ... data from a number of assessments including the IBS-Severity ...
(Date:8/26/2014)... -- NeuroSigma, Inc., a Los Angeles -based ... announced that it has filed a registration statement on ... relating to a proposed initial public offering of its ... and the price range for the proposed offering have ... act as the book-running manager for the proposed offering, ...
(Date:8/26/2014)... The 20 ambassadors representing the ALS ... issued the following statement on Facebook today regarding the ... new funding specifically for ALS research: , “Who would ... ice would raise all this awareness and funding toward ... on behalf of the entire ALS community, would like ...
Breaking Biology Technology:Stress Relief: 1 Way to De-Stress Your Beverage Formula 2Stress Relief: 1 Way to De-Stress Your Beverage Formula 3Stress Relief: 1 Way to De-Stress Your Beverage Formula 4A Perfect Record: WriteResult Maintains a 100% On-Time ePRO Record with Latest Irritable Bowel (IBS) Study Data Lock 2ALS TDI’s Young Faces of ALS Ambassadors Thank You for Accepting the Ice Bucket Challenge to End ALS 2ALS TDI’s Young Faces of ALS Ambassadors Thank You for Accepting the Ice Bucket Challenge to End ALS 3ALS TDI’s Young Faces of ALS Ambassadors Thank You for Accepting the Ice Bucket Challenge to End ALS 4
... Services Provided by Interleukin ... ... ,Interleukin Genetics, Inc. (Amex: ILI ), and OralDNA Labs, Inc., ... Genetics, proprietary PST(R) Genetic Test. The PST(R),Genetic Test provides a means ...
... Aug. 13 WaferGen Biosystems,Inc. (OTC Bulletin Board: ... cell biology and stem cell research systems,today highlighted ... results for the quarter and six months ended ... Milestones:, -- Initiation of alpha testing of ...
... Bio-Forge® product line through the use of its new interactive micro ... proprietary technology, plant growth cycles and hormone balance--the critical relationship that ... , ... Houston, TX (PRWEB) August 14, 2008 -- StollerUSA ...
Cached Biology Technology:Interleukin Genetics Licenses its PST(R) Genetic Test to OralDNA Labs 2Interleukin Genetics Licenses its PST(R) Genetic Test to OralDNA Labs 3Interleukin Genetics Licenses its PST(R) Genetic Test to OralDNA Labs 4WaferGen Announces Second Quarter 2008 Financial Results 2WaferGen Announces Second Quarter 2008 Financial Results 3WaferGen Announces Second Quarter 2008 Financial Results 4WaferGen Announces Second Quarter 2008 Financial Results 5WaferGen Announces Second Quarter 2008 Financial Results 6WaferGen Announces Second Quarter 2008 Financial Results 7WaferGen Announces Second Quarter 2008 Financial Results 8StollerUSA Launches Bio-Forge.com to Offer Solutions for Crops Under Stress 2StollerUSA Launches Bio-Forge.com to Offer Solutions for Crops Under Stress 3
... and experiment control software. Records waveform, ... and off-line analysis. powerful stimulus generation ... allowing the user to customize the ... range from basic data logging to ...
... a direct antibiotic-based selection ... Recombinant selection depends solely ... the need for costly ... and inexpensive process provides ...
... designed and created in order to provide ... analysis tool. We incorporated the suggestions and ... software. Their main requirements were ease- of- ... cost. GeneMarker can perform analysis on ...
... extraction through columns is a well-known separation ... Typical applications are in DNA/RNA extraction in ... compound purification in chemical or analytical laboratories. ... the Genesis series instruments for smaller scales. ...
Biology Products: