Navigation Links
Short DNA strands in the genome may be key to understanding human cognition and diseases
Date:11/21/2012

Short snippets of DNA found in human brain tissue provide new insight into human cognitive function and risk for developing certain neurological diseases, according to researchers from the Departments of Psychiatry and Neuroscience at Mount Sinai School of Medicine. The findings are published in the November 20th issue of PLoS Biology.

There are nearly 40 million positions in the human genome with DNA sequences that are different than those in non-human primates, making the task of learning which are important and which are inconsequential a challenge for scientists. Rather than comparing these sequences strand by strand, Schahram Akbarian, MD, PhD, Professor of Psychiatry and Neuroscience at Mount Sinai School of Medicine, wanted to identify the crucial set of differences between the two genomes by looking more broadly at the chromatin, the structure that packages the DNA and controls how it is expressed.

They found hundreds of regions throughout the human genome which showed a markedly different chromatin structure in neurons in the prefrontal cortex, a brain region that controls complex emotional and cognitive behavior, compared to non-human primates. The findings of the study provide important insights for diseases that are unique to humans such as Alzheimer's disease and autism.

"While mapping the human genome has taught us a great deal about human biology, the emerging field of epigenomics may help us identify previously overlooked or discarded sequences that are key to understanding disease," said Dr. Akbarian. "We identified hundreds of loci that represent untapped areas of study that may have therapeutic potential."

Dr. Akbarian and his research team isolated small snippets of chromatin fibers from the prefrontal cortex. Next, they analyzed these snippets to determine what genetic signals they were expressing. Many of the sequences with human-specific epigenetic characteristics were, until recently, considere
'/>"/>

Contact: Mount Sinai Press Office
newsmedia@mssm.edu
212-241-9200
The Mount Sinai Hospital / Mount Sinai School of Medicine
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. The long, err, short of it
2. Glycogen accumulation in neurons causes brain damage and shortens the lives of flies and mice
3. New product to replace fishmeal could help prevent global food shortage
4. Reed Elsevier Environmental Challenge shortlists 2012 projects
5. Short stretches of piRNA evaluate cells genetic history
6. UC Davis study finds that above-normal weight alone does not increase the short-term risk of death
7. A shortcut to sustainable fisheries
8. Plants unpack winter coats when days get shorter
9. Bone marrow stem cells do not improve short-term recovery after heart attack
10. Leading evolutionary scientist to discuss how genome of bacteria has evolved
11. Darwin in the genome
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/1/2015)... 1, 2015  NXT-ID, Inc. (NASDAQ: NXTD ) ... on the growing mobile commerce market, announces the second ... is underway to early access pre-order customers. ... at retail outlets including Walmart, Target, AT&T, Dunkin, Donuts, ... was accepted at all outlets and very easy to ...
(Date:3/30/2015)... and Markets ( http://www.researchandmarkets.com/research/lc9bnl/global_gesture ) has announced ... in Automotive Sector 2014-2018" report to their offering. ... market in Automotive Sector to grow at a CAGR ... recognition is the ability of a device to identify ... recognition technology can be 2D-based or 3D-based. It uses ...
(Date:3/24/2015)... 24, 2015   NexID Biometrics LLC, whose ... needs, today announced the beginning of shipments of version ... The company, based in Potsdam, N.Y. ... Connect:ID Expo, which began here today at the Walter ... 2.0 of its SDK boosts the accuracy rate range ...
Breaking Biology News(10 mins):NXT-ID Reports Second Shipment of Wocket Smart Wallets Underway to Early Access Pre-order Customers and Provides User Feedback 2NXT-ID Reports Second Shipment of Wocket Smart Wallets Underway to Early Access Pre-order Customers and Provides User Feedback 3NXT-ID Reports Second Shipment of Wocket Smart Wallets Underway to Early Access Pre-order Customers and Provides User Feedback 4Global Gesture Recognition Market in Automotive Sector Report 2015 - Growing Number of Partnerships 2NexID Begins Shipments Of Version 2.0 Fake-Finger-Detection Solution 2
... Radula buccinifera is nothing of the kind. The species ... It has gone on to be the most commonly collected ... Zealand, according to results of research led by Dr Matt Renner ... and morphological evidence show that what was thought to be one ...
... time quantified the energy cost to aquatic animals when they ... Studying fibreglass casts of sea turtles in a wind tunnel, ... drag by less than five per cent for large adult ... more than 100 per cent on smaller or juvenile animals. ...
... RIVERSIDE, Calif. Cowpea is a protein-rich legume crop that ... and their livestock. Immensely important in many parts of the ... the diet and economy of hundreds of millions of people ... a growing world population, new cowpea varieties with desirable traits, ...
Cached Biology News:2 grants to UC Riverside boost scientists' efforts in developing improved cowpea varieties 22 grants to UC Riverside boost scientists' efforts in developing improved cowpea varieties 32 grants to UC Riverside boost scientists' efforts in developing improved cowpea varieties 42 grants to UC Riverside boost scientists' efforts in developing improved cowpea varieties 52 grants to UC Riverside boost scientists' efforts in developing improved cowpea varieties 6
(Date:4/24/2015)... 2015 /PRNewswire/ - BioAmber Inc. (NYSE: BIOA ) ... supplier of bio-succinic acid used to produce a ... applications that Bayer MaterialScience has begun commercializing.    ... eco, a series of bio-based waterborne polyurethane ... as 65%.  IMPRANIL ® eco has been ...
(Date:4/24/2015)... 2015 /CNW Telbec/ - Mirego, leader in mobile strategies and ... three mobile app extensions for the all new Apple Watch. ... Familiprix, OMSignal and MediaMiser, these extensions will reinvent the way ... specifically for wrist use.  Available today in ... highly customizable tactile smartwatch that makes for an excellent buddy ...
(Date:4/24/2015)... 2015 PAREXEL International Corporation (NASDAQ: PRXL ... that Partnerships in Clinical Trials named PAREXEL,s Drew ... Innovator of the Year.  The honor recognizes Mr. Garty,s ... Perceptive MyTrials ® Data-Driven Monitoring solution. ... 2015 Partnership Awards in Boston , ...
(Date:4/23/2015)... Ralco announced today that it has entered ... the exclusive worldwide rights to sell and distribute the ... new in-line milk system that increases the profitability and ... supplementation milk cups within a farrowing facility while the ... producers get Birthrightâ„¢ milk to the right pigs and ...
Breaking Biology Technology:Bayer MaterialScience Names BioAmber As Its Supplier For New Product Line - Bio-succinic acid forms backbone of innovative new bio-based polyurethanes for textiles 2Bayer MaterialScience Names BioAmber As Its Supplier For New Product Line - Bio-succinic acid forms backbone of innovative new bio-based polyurethanes for textiles 3Bayer MaterialScience Names BioAmber As Its Supplier For New Product Line - Bio-succinic acid forms backbone of innovative new bio-based polyurethanes for textiles 4Familiprix, OMSignal and MediaMiser apps available today for Apple Watch 2PAREXEL Honored With 2015 Clinical Innovator Of The Year Award From Partnerships In Clinical Trials 2PAREXEL Honored With 2015 Clinical Innovator Of The Year Award From Partnerships In Clinical Trials 3PAREXEL Honored With 2015 Clinical Innovator Of The Year Award From Partnerships In Clinical Trials 4PAREXEL Honored With 2015 Clinical Innovator Of The Year Award From Partnerships In Clinical Trials 5Ralco Acquires License to Birthrightâ„¢ Moveable Milk Cup 2
... VANCOUVER , June 30 /PRNewswire/ - Sirius Genomics, ... has been appointed Senior Director of Business Development. , ... "Sirius Genomics is on ... Kam,s extensive background in partnering with both global pharmaceutical and medical ...
... Tekscan, Inc. ... the traditional pin connection, Tekscan is now offering a lower-cost termination method to enable OEM ... , ... -- Tekscan, Inc. announces a new lower-cost connection option for its custom FlexiForce® sensors ...
... A ... users sports performance , ... Denmark (PRWEB) June 30, 2010 -- Recent researches have found scientific evidence that proves ... researchers from Denmark revealed that the level of enhancement of performance due to the use ...
Cached Biology Technology:Sirius Genomics Announces Appointment of Senior Director of Business Development 2Lower-Cost ZIF and LIF-Compatible Connection Option for Tekscan Custom Force Sensors 2Recent Study Reports Reveals that HGH May Aid Performance 2
...
... Cell Dissociation Buffers are membrane-filtered ... salts chelating agents and cell-conditioning agents ... balanced salt solution or Ca2+- ... dissociation of mammalian cells from support ...
... are membrane-filtered isotonic and enzyme-free aqueous ... cell-conditioning agents in either Ca2+- and ... Ca2+- and Mg2+-free phosphate-buffered saline ... from support substrates and each other ...
... Antibody Modification Services ,,GenScript offers ... labeling and antibody fragmentation. Labeling antibodies ... for visualization and quantitation of the ... is preferable to use only the ...
Biology Products: