Navigation Links
Short DNA strands in the genome may be key to understanding human cognition and diseases
Date:11/21/2012

Short snippets of DNA found in human brain tissue provide new insight into human cognitive function and risk for developing certain neurological diseases, according to researchers from the Departments of Psychiatry and Neuroscience at Mount Sinai School of Medicine. The findings are published in the November 20th issue of PLoS Biology.

There are nearly 40 million positions in the human genome with DNA sequences that are different than those in non-human primates, making the task of learning which are important and which are inconsequential a challenge for scientists. Rather than comparing these sequences strand by strand, Schahram Akbarian, MD, PhD, Professor of Psychiatry and Neuroscience at Mount Sinai School of Medicine, wanted to identify the crucial set of differences between the two genomes by looking more broadly at the chromatin, the structure that packages the DNA and controls how it is expressed.

They found hundreds of regions throughout the human genome which showed a markedly different chromatin structure in neurons in the prefrontal cortex, a brain region that controls complex emotional and cognitive behavior, compared to non-human primates. The findings of the study provide important insights for diseases that are unique to humans such as Alzheimer's disease and autism.

"While mapping the human genome has taught us a great deal about human biology, the emerging field of epigenomics may help us identify previously overlooked or discarded sequences that are key to understanding disease," said Dr. Akbarian. "We identified hundreds of loci that represent untapped areas of study that may have therapeutic potential."

Dr. Akbarian and his research team isolated small snippets of chromatin fibers from the prefrontal cortex. Next, they analyzed these snippets to determine what genetic signals they were expressing. Many of the sequences with human-specific epigenetic characteristics were, until recently, considere
'/>"/>

Contact: Mount Sinai Press Office
newsmedia@mssm.edu
212-241-9200
The Mount Sinai Hospital / Mount Sinai School of Medicine
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. The long, err, short of it
2. Glycogen accumulation in neurons causes brain damage and shortens the lives of flies and mice
3. New product to replace fishmeal could help prevent global food shortage
4. Reed Elsevier Environmental Challenge shortlists 2012 projects
5. Short stretches of piRNA evaluate cells genetic history
6. UC Davis study finds that above-normal weight alone does not increase the short-term risk of death
7. A shortcut to sustainable fisheries
8. Plants unpack winter coats when days get shorter
9. Bone marrow stem cells do not improve short-term recovery after heart attack
10. Leading evolutionary scientist to discuss how genome of bacteria has evolved
11. Darwin in the genome
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... University, Sweden, have explored two different ways that ... leading to the formation of oxygen molecules in ... the scientific journal Nature Communications . , ... synthetic catalysts for water oxidation, which are key ... direct storage of solar energy in fuels like ...
(Date:7/11/2014)... under the normal circumstances, astrocytes participate in ... environment, and exhibit therapeutic and repairing effects ... studies have found that nerve cells differentiated ... have reduced viability, which produces influences on ... Kailuan General Hospital, Hebei United University, China ...
(Date:7/10/2014)... and other major cities in New Mexico, nearly every ... wastewater rather than precious potable water supplies. Across the ... all golf courses receive treated effluent. Reusing the effluent ... golf courses and homeowners alike fertilize their lawns during ... nitrate. A New Mexico State University turfgrass expert has ...
Breaking Biology News(10 mins):Molecular snapshots of oxygen formation in photosynthesis 2'Tailored' water -- the latest in lawn care 2
... explain the response of patients with chronic obstructive pulmonary ... reported today (Oct. 25) at the American Society of ... used statistical methods to combine results from four individual ... moderate to severe COPD. Over 6.3 million unique ...
... cells. They,re equally indispensible in both cases. Without our bony ... cytoskeletons, our cells, which come in roughly 200 different shapes ... Using cells from the stem of a seedling as ... St. Louis seeks to understand the molecular mechanisms that organize ...
... is hosting the region,s leading scientists for discussions ... most devastating and intractable diseases of humans, including ... fungal meningitis. The Cell Biology of Eukaryotic ... campus and provides an environment for scientific discussions ...
Cached Biology News:DNA variants may influence COPD patients' response to inhaled bronchodilators 2Samurai sword protein makes strategic cuts in cell skeletons 2Samurai sword protein makes strategic cuts in cell skeletons 3Samurai sword protein makes strategic cuts in cell skeletons 4Samurai sword protein makes strategic cuts in cell skeletons 5
(Date:7/11/2014)... AZ (PRWEB) July 11, 2014 ... device company specializing in the soft tissue reconstruction ... All-Suture Anchor System for surgeries involving the shoulder ... fixation through a novel, inserter-controlled deployment method. The ... to partial deployment, anchor pull-out, or anchor displacement ...
(Date:7/10/2014)... (PRWEB) July 10, 2014 Understanding the ... channel-expressing cell lines, and the gap that currently exists ... that expand its industry-leading portfolio of validated ion channel ... ion channel-expressing cell lines, as ion channels control many ... control this activity creates the potential to treat a ...
(Date:7/10/2014)... CA (PRWEB) July 10, 2014 OMICS ... Bioanalytical techniques during 18-20 August, 2014 at Double Tree ... review the recent developments in Analytical & Bioanalytical research ... globe. , Speaking on this occasion, Dr. Srinubabu Gedela, ... Analytica Acta conference is a remarkable one in bringing ...
(Date:7/10/2014)... 2014 On July 9 Prime ... presented Russia,s first national "Industry" ... Company is developing a unique project called MabNext ... a number of innovative drugs based on monoclonal antibodies ... took place at the International Exhibition "Innoprom 2014" in ...
Breaking Biology Technology:Cayenne Medical Launches SureLock™ All-Suture Anchor System for Shoulder and Extremity Surgery 2Cayenne Medical Launches SureLock™ All-Suture Anchor System for Shoulder and Extremity Surgery 3Leader in Ion Channel Research Announces Newly Validated and Re-Engineered Cells 2Leader in Ion Channel Research Announces Newly Validated and Re-Engineered Cells 3A Critical Review of Analytical Techniques for Improved Living Standards 2A Critical Review of Analytical Techniques for Improved Living Standards 3A Critical Review of Analytical Techniques for Improved Living Standards 4Dmitry Medvedev Presented BIOCAD the First National "Industry" Award 2
... YORK, Sept. 24 Stephen Simes, chief executive,officer ... (http://www.biosantepharma.com ) will be featured in an exclusive ... at 10:30 a.m. EDT. The interview,will be posted ... on September 26. The interview will cover ...
... Kendle (Nasdaq: KNDL ), a,leading, global ... President and Chief Financial Officer Karl,"Buzz" Brenkert, III ... at the Grand Hyatt New York, Park Avenue ... Kendle,s presentation is scheduled for,Wednesday, Sept. 26 at ...
... WILMINGTON, Mass., Sept. 24 OmniSonics Medical,Technologies, Inc., ... vascular disease, today announced the appointment of J. ... Board. Mr. Cole is a founding partner ... focuses exclusively on emerging healthcare technology,companies. He brings ...
Cached Biology Technology:WallSt.net Announces Upcoming Interview with CEO of BioSante Pharmaceuticals 2Kendle to Present at the UBS Global Life Sciences Conference 2OmniSonics Appoints J. Daniel Cole Chairman of the Board 2
...
... Modification Services ,,GenScript offers many ... and antibody fragmentation. Labeling antibodies with ... visualization and quantitation of the target ... preferable to use only the antigen-binding ...
... are designed for ultra-sensitive detection of ... PVDF membranes. Since all necessary reagents ... antibodies), the WesternBreeze Kits save you ... and getting your final results. Solutions ...
Request Info...
Biology Products: