Navigation Links
Shock tactics: Bioelectrical therapy for cancer and birth defects?
Date:10/18/2010

Stem cell therapies hold increasing promise as a cure for multiple diseases. But the massive potential of a healthy stem cell has a flip side, as faulty regulation of stem cells leads to a huge range of human diseases. Even before birth, mistakes made by the stem cells of the foetus are a major cause of congenital defects, and cancer is also caused by the body losing control of stem cell function. Guiding stem cells along the correct pathways and, where necessary, reversing their mistakes is the goal of everyone in this field. Now, Michael Levin (http://www.drmichaellevin.org/) and colleagues from Tufts University (http://www.tufts.edu/), Medford, MA, have identified a novel and readily modifiable signal by which an organism can control the behaviour of stem cell offspring. Their work is published in Disease Models & Mechanisms on October 19th, 2010, at http://dmm.biologists.org/.

Levin's laboratory works on an intriguing phenomenon: bioelectrical signalling. There is always a difference in voltage, called the transmembrane potential, between the inside and outside of all cells, and controlling exactly what this difference is turns out to be vitally important. Specialised protein checkpoints sited in a cell's outer membrane regulate ion flow in and out of the cell, producing voltage gradients. These, combined with more conventional protein-based signalling systems, can specify cell destiny.

Levin's team already knew from collaborative work with David Kaplan's lab, also at Tufts, that the properties of human stem cells growing in artificial culture could be drastically altered by changing their transmembrane potential. Now they have taken this work one important step further, by asking whether tampering with the transmembrane potential of one kind of cell can have a domino effect in a whole organism, altering the destiny of other cell types. To do this, they focused on the development of neural crest stem cells, which are responsible for directing development of the face and heart, but which also generate melanocytes, the pigment cells of the skin. Using frog tadpoles and melanocytes as a model system, they showed that tweaking the transmembrane potential of a tiny population of 'instructor' cells sends a signal to developing melanocytes that causes them to overgrow and start to resemble metastatic cancer cells. Most excitingly, they found that the signal can travel over long distances in the tadpole, and that the messenger carrying it is serotonin an important neurotransmitter involved in mood regulation and many other aspects of nervous system function.

This novel bioelectrical method of changing stem cell behaviour has huge implications. It is very likely that there are similar 'instructor' cells that direct other important cell populations, and changing their voltage gradients would be relatively easy (Levin's lab simply used an anti-parasitic drug already available on prescription). The resulting bioelectrical therapy could potentially be harnessed to improve regenerative repair after injury, repair birth defects and detect and prevent cancer.


'/>"/>

Contact: Sarah Allan
sarah.allan@biologists.com
The Company of Biologists
Source:Eurekalert

Related biology news :

1. Molecular mechanism of anaphylactic shock decoded
2. Shock and kill research gives new hope for HIV-1 eradication
3. Targeting helpers of heat shock proteins could help treat cancer, cardiovascular disease
4. Septic shock: Nitric oxide beneficial after all
5. Kapahi to receive GSAs 2010 Nathan Shock New Investigator Award
6. Breast cancer cells recycle to escape death by hormonal therapy
7. On the trail of a targeted therapy for blood cancers
8. Researchers identify promising gene target for neuroblastoma therapy
9. Gene therapy restores vision to mice with retinal degeneration
10. How eating fruit and vegetables can improve cancer patients response to chemotherapy
11. Researchers at UH explore use of fat cells as heart attack therapy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/16/2017)... 2017   Bridge Patient Portal , an ... MD EMR Systems , an electronic medical record ... have established a partnership to build an interface ... GE Centricity™ products, including Centricity Practice Solution (CPS), ... These new integrations will allow healthcare delivery networks ...
(Date:4/24/2017)... WASHINGTON , April 24, 2017 ... counsel and partner with  Identity Strategy Partners, LLP ... "With or without President Trump,s March 6, ... Foreign Terrorist Entry , refugee vetting can be instilled ... refugee resettlement. (Right now, all refugee applications are ...
(Date:4/18/2017)... -- Socionext Inc., a global expert in SoC-based imaging and computing solutions, ... which features the company,s hybrid codec technology. A demonstration utilizing TeraFaces ... will be showcased during the upcoming Medtec Japan at Tokyo Big ... Las Vegas Convention Center April 24-27. ... Click here for an image of ...
Breaking Biology News(10 mins):
(Date:9/19/2017)... , ... September 19, 2017 , ... ... pleased to announce the recipients of its 2017 Science Student Award. The scholarship ... qualities, and involvement with community service defray the costs of obtaining their science ...
(Date:9/18/2017)... ... September 18, 2017 , ... ... the move of the SPIE Digital Library ( http://www.spiedigitallibrary.org ) on 15 August ... create an improved user experience and incorporate a number of enhancements and new ...
(Date:9/14/2017)... (PRWEB) , ... September 14, ... ... Global Analytical Services, formally introduces its flexible scientist program (FSP)-- a flexible ... preferred-rate pricing. The FSP, which combines SSCI’s extensive project-based analytical and solid-state ...
(Date:9/14/2017)... San Antonio, Texas (PRWEB) , ... September 14, 2017 , ... ... across San Antonio on Saturday, Sept. 16. , For six hours that day, the ... The Match registry at more than 30 H-E-B grocery stores in San Antonio. , ...
Breaking Biology Technology: