Navigation Links
'Shock and kill' research gives new hope for HIV-1 eradication
Date:6/4/2009

Latent HIV genes can be 'smoked out' of human cells. The so-called 'shock and kill' technique, described in a preclinical study in BioMed Central's open access journal Retrovirology, might represent a new milestone along the way to the discovery of a cure for HIV/AIDS.

Dr. Enrico Garaci, president of the Istituto Superiore di Sanit (the Italian Institute of Health) and Dr. Andrea Savarino, a retrovirologist working at the institution, worked with a team of researchers to study the so-called "barrier of latency" which has been the main obstacle to HIV eradication from the body.

Cells harbouring a quiescent HIV genome are responsible for HIV persistence during therapy. In other words, HIV-1 genes become pieces of the human organism, and many scientists have simply thought there is nothing we can do. Dr Savarino's team aimed to 'smoke out' the virus in order to render the latently infected cells targetable by the immune system or artificial means. They write, "This can be achieved using inhibitors of histone deacetylases (HDACs), which are a class of enzymes that maintain HIV latency. However, their effects on HIV are evident only when used in toxic quantities".

To overcome this problem, the Italian researchers tested a collection of HDAC inhibitors, some of which specifically target only certain enzyme isoforms (class I HDACs) that are involved in HIV latency. The toxicity of this approach, however, was not markedly decreased, although it compromises a more limited number of cellular pathways. Moreover, at non-toxic quantities, class I HDAC inhibitors were able to induce the 'awakening' of a portion of cells within a latently infected cell population. The researchers then repeated the experiment adding a drug inducing oxidative stress, buthionine sulfoximine (BSO). The results showed that BSO recruited cells non-responsive to the HDAC inhibitors into the responding cell population. An important result was that the infected cell
'/>"/>

Contact: Graeme Baldwin
graeme.baldwin@biomedcentral.com
44-787-741-1853
BioMed Central
Source:Eurekalert

Page: 1 2

Related biology news :

1. Molecular mechanism of anaphylactic shock decoded
2. Immune system protein accurate predictor of survival in pediatric septic shock
3. Too much fructose could leave dieters sugar shocked
4. Scientists explain how death receptors designed to kill our cells may make them stronger
5. Tree survival skills
6. New Southern California beetle killing oaks
7. New study overturns orthodoxy on how macrophages kill bacteria
8. UGA licenses invention that kills food-borne pathogens in minutes
9. University researchers to develop coatings that kill superbugs
10. Cleaning up oil spills can kill more fish than spills themselves, say Queens biologists
11. Termite killer lingers as a potent greenhouse gas
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/21/2014)... scientists including researchers from the University of Georgia recently published ... the journal Science . Their discovery paves the way ... in farming and industry. , Canola is grown across ... crop is increasingly cultivated in Georgia. Canola oil used for ... fat and rich supply of omega-3 fatty acids, but the ...
(Date:8/21/2014)... in past decade, GTA still violates Canada,s ozone ... the Greater Toronto Area (GTA) has significantly reduced ... the city continues to violate the Canada-wide standards ... or aggravate health problems such as asthma, emphysema ... of complex photochemical reactions involving volatile organic compounds ...
(Date:8/21/2014)... Ind. -- A new study of American singles ... men have the highest orgasm rates. On average, ... with their sexual orientation making little difference. For ... average, women experience orgasm 62.9 percent of the ... and this pattern varies with women,s sexual orientation, ...
Breaking Biology News(10 mins):Canola genome sequence reveals evolutionary 'love triangle' 2Despite a significant reduction in smog-producing toxins, the Greater Toronto Area still violates Canada's standards for ozone air pollution 2Orgasm rates for single women less predictable than men's, vary by sexual orientation 2Orgasm rates for single women less predictable than men's, vary by sexual orientation 3Orgasm rates for single women less predictable than men's, vary by sexual orientation 4
... Western forests may help the United States reduce its ... often used by forest managers to reduce underbrush and ... than wildfires of the same size. "It appears ... a climate change strategy," says Christine Wiedinmyer, a scientist ...
... ,, EASTON, Pa. , March 17 ... it quick and easy to design your own PCB shield. Visit the ... www.orbel.com and select from a wide variety of ... Board Shield Wizard. The easy-to-use application lets you ...
... action by governments in Central and West Africa and ... trade, according to a new analysis of elephant trade ... data held in the Elephant Trade Information System (ETIS), ... failure of law enforcement in key elephant range States ...
Cached Biology News:Prescribed burns may help reduce US carbon footprint 2Prescribed burns may help reduce US carbon footprint 3Orbel Introduces the Board Shielding Wizard 2New analysis points to ivory enforcement failures in parts of Africa, Asia 2
(Date:8/20/2014)... your ear could improve the health of your heart, ... of Leeds used a standard TENS machine like those ... to the tragus, the small raised flap at the ... ear canal. , The stimulation changed the influence of ... nervous signals that can drive failing hearts too hard. ...
(Date:8/20/2014)... August 20, 2014 GraphDB™ ... today including improvements to the enterprise replication cluster, ... for Lucene, SOLR and Elasticsearch. This release happens ... high performance triplestore – GraphDB™ was formerly known ... deploying the only mature enterprise resilient RDF triplestore ...
(Date:8/19/2014)... (PRWEB) August 19, 2014 Shimadzu ... chromatography systems, Prominence-i and Nexera-i, adding to the ... Combining excellent functionality, an intuitive operating environment, and ... a more efficient workflow for conventional to ultra-high-speed ... innovative, intuitive and intelligent design so users can ...
(Date:8/19/2014)... 19, 2014 A Geisinger researcher on a ... a Centers for Disease Control and Prevention (CDC) award ... health concern. Joseph Boscarino , Ph.D. ... a team of researchers nominated for the Centers for ... Award for Data Methods and Study Design. ...
Breaking Biology Technology:'Tickling' your ear could be good for your heart 2Ontotext Improves Its RDF Triplestore, GraphDB™ 6.0: Enterprise Resilience, Faster Loading Speeds and Connectors to Full-Text Search Engines Top the List of Enhancements 2Ontotext Improves Its RDF Triplestore, GraphDB™ 6.0: Enterprise Resilience, Faster Loading Speeds and Connectors to Full-Text Search Engines Top the List of Enhancements 3Ontotext Improves Its RDF Triplestore, GraphDB™ 6.0: Enterprise Resilience, Faster Loading Speeds and Connectors to Full-Text Search Engines Top the List of Enhancements 4Shimadzu’s New i-Series Integrated Liquid Chromatography Systems Provide Laboratories Wider Range of Analytical Capabilities 2Shimadzu’s New i-Series Integrated Liquid Chromatography Systems Provide Laboratories Wider Range of Analytical Capabilities 3Geisinger investigator nominated for federal award 2Geisinger investigator nominated for federal award 3
... the cables as we move deeper into our highly mobile, ... we are nowhere without energy to power the laptops, mobile ... turned the average business traveler into a Socket Scout, finding ... coffee houses. Indeed, Im usually the last person to board ...
... (Commerce) has qualified five small businesses for investor tax ... Tax Credit Programs. , ,"By encouraging investors through tax ... to turn these great ideas into viable, job-creating businesses," ... and Venture Fund Tax Credit Programs offer Wisconsin income ...
... international corporation used to take a lifetime of hard work. ... spirit, and in less than 30 days. , ,The idea ... that 80 percent of businesses fail within the first five ... be discouraged by such an estimate. , ,However, the ...
Cached Biology Technology:Power for the people 2Five technology companies qualify for investor tax credits 230 days to success: Three simple steps to create your own international startup 230 days to success: Three simple steps to create your own international startup 330 days to success: Three simple steps to create your own international startup 430 days to success: Three simple steps to create your own international startup 5
Kit Components: Anti-Acetylated Histone H3 Salmon Sperm DNA/Protein A Agarose All necessary buffers. ...
Liquid. 50 μg/ml in PBS, pH 7.4. PROTECT FROM LIGHT. A convenient form of propidium iodide useful for flow cytometry studies. RTECS SF7949600, CAS 25535-16-4, M.W. 668.4. ...
Lyophilized solid. Suitable for evaluating functional activity of human complement components and for other research requiring a high level of hemolytic activity. ...
... Pro systems are high-precision microarrayers capable ... biological samples. VersArray ChipWriter Pro systems ... density, and reproducibility to deliver unparalleled ... substrates. Their modular component design and ...
Biology Products: