Navigation Links
Shining light on neurodegenerative pathway
Date:9/18/2013

University of Adelaide researchers have identified a likely molecular pathway that causes a group of untreatable neurodegenerative diseases, including Huntington's disease and Lou Gehrig's disease.

The group of about 20 diseases, which show overlapping symptoms that typically include nerve cell death, share a similar genetic mutation mechanism ‒ but how this form of mutation causes these diseases has remained a mystery.

"Despite the genes for some of these diseases having been identified 20 years ago, we still haven't understood the underlying mechanisms that lead to people developing clinical symptoms," says Professor Robert Richards, Head of Genetics in the University's School of Molecular and Biomedical Sciences.

"By uncovering the molecular pathway for these diseases, we now expect to be able to define targets for intervention and so come up with potential therapies. Ultimately this will help sufferers to reduce the amount of nerve cell degeneration or slow its progression."

In an article published in Frontiers in Molecular Neuroscience, Professor Richards and colleagues describe their innovative theory and new evidence for the key role of RNA in the development of the diseases. RNA is a large molecule in the cell that copies genetic code from the cell's DNA and translates it into the proteins that drive biological functions.

People with these diseases all have expanded numbers of copies of particular sequences of the 'nucleotide bases' which make up DNA.

"In most cases people with these diseases have increased numbers of repeat sequences in their RNA," says Professor Richards. "The disease develops when people have too many copies of the repeat sequence. Above a certain threshold, the more copies they have the earlier the disease develops and the more severe the symptoms. The current gap in knowledge is why having these expanded repeat sequences of genes in the RNA translates into actual
'/>"/>

Contact: Robert Richards
robert.richards@adelaide.edu.au
61-422-007-867
University of Adelaide
Source:Eurekalert

Page: 1 2

Related biology news :

1. Recent highlights in Molecular Biology and Evolution
2. Lab-on-a-chip tech, brain mapping & microbiome highlighted at translational med meeting
3. Research highlights from ICAAC meeting
4. Survey highlights barriers to interdisciplinary environmental science
5. Rutgers study: Worms may shed light on human ability to handle chronic stress
6. AGU journal highlights -- Aug. 13, 2013
7. Family matters: Evolutionary relationships among species of magic mushrooms shed light on fungi
8. Montana State University researchers highlight bears use of Banff highway crossings
9. Light that moves and molds gels
10. Study highlights possible new approach to prostate cancer treatment
11. Controlling genes with light
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/22/2014)... 14, 2014, by lightning from a weather system that moved ... fires: Stokes Fire, Gold Hikes Fire, French Creek Fire and ... now one larger fire. The fires are burning in timber ... acres in size. The present fire situation continues to ... firefighter safety is the priority on the Carlton Complex fires. ...
(Date:7/22/2014)... for Health Policy and Economics have linked tighter ... rates for schizophrenic individuals. , The study comes ... health actually save money, when other costs are ... an extra approval step before tests or treatments ... called prior authorization is intended to encourage ...
(Date:7/22/2014)... research team from the National Institute of Standards ... has demonstrated a dramatically improved technique for analyzing ... vibration "signatures." The new NIST technique is an ... spectroscopy, but one that delivers signals that are ... scattering, and 100 times stronger than obtained from ...
Breaking Biology News(10 mins):Are state Medicaid policies sentencing people with mental illnesses to prison? 2Enhanced NIST instrument enables high-speed chemical imaging of tissues 2Enhanced NIST instrument enables high-speed chemical imaging of tissues 3
... (RFRH) systems with mulches were first researched in the ... water availability and to increase crop production. In RFRH ... bare or mulched furrows serve as planting zones. The ... in many parts of the world as a means ...
... of 34 institutions in 15 countries contributing to the measurements ... network, InGOS. , The network focuses on providing accurate information ... for a more vigorous climate action. In order to ... of greenhouse gas emissions is essential and not only ...
... article in the New England Journal of Medicine ... B was able to convert severe hemophilia to moderate or ... Methods Editor for Human Gene Therapy and ... represents an important milestone and "demonstrates unequivocally that gene therapy ...
Cached Biology News:Improved rainwater harvesting system promising 2DTU is participating in a European network on measurement of greenhouse gases 2Commentary and podcast on landmark gene therapy clinical trial for hemophilia B 2
(Date:7/22/2014)... Massachusetts og SHENZHEN ... Tech Solutions Co., LTD, (BGI Tech), et datterselskab ... lancering af en ny human whole exome-sekvenseringstjeneste baseret ... Complete Genomics, højt anset i branchen for at ... højfølsom registrering af alle typer varianter, blev købt ...
(Date:7/22/2014)... Switzerland (PRWEB) July 22, 2014 ... are becoming an increasingly common sight. The rapid ... they are now well- established as a core ... low maintenance has made them the gas analyzer ... locations and conditions encountered in some processes have ...
(Date:7/22/2014)... (PRWEB) July 22, 2014 Holomic ... with the debut of its fluorescent immunoassay reader, ... Chemistry (AACC) meeting in Chicago, July 28-31, 2014. ... top versions, the HRDR-300 is a highly sensitive, ... to analyze fluorescent lateral flow immunoassays with high ...
(Date:7/21/2014)... 21, 2014 Lawrence Livermore ... Board (WIB) and Las Positas College (LPC) recently ... education and hands-on training for veterans, officials recently ... at Las Positas is designed to help ... engineering technician careers, and establishes a pipeline of ...
Breaking Biology Technology:BGI Tech lancerer Human Whole Exome-sekvenseringstjeneste på Complete Genomics avancerede platform 2METTLER TOLEDO Shows How Tunable Diode Lasers (TDLs) Can Be Installed Where No TDLs Have Gone Before 2Holomic to Debut HRDR-300 Fluorescent Immunoassay Reader at the AACC 2014 2Engineering Program Established for Veterans 2Engineering Program Established for Veterans 3
... EUREKA Cluster dedicated to Smart Systems Integration, will be ... community on 14-17 June 2011 in Helsinki, Finland. The ... the creation of new consortia and new projects by ... discuss proposals. EURIPIDES, in close cooperation with VTT and ...
... 20, 2011 Harvest Technologies Corp. ( www.harvesttech.com ) ... sixty patient Heart Failure trial have been enrolled at ... trial is intended to evaluate the safety and clinical ... patients with Congestive Heart Failure (CHF) when using a ...
... full year as a public company, 2010, the biotechnology developer Divine ... and grew Q4 revenue by 88 percent over the previous Q4, ... $5.4 million, up by $1.9 million over the previous year. Fourth-quarter ... quarter of 2009. The maker of topical treatments for ...
Cached Biology Technology:Harvest Technologies Announces Initial Enrollment in Its REVIVE-1 Trial (REtrograde Vascular Infusion of BMAC to ImproVe Heart FailurE) 2Divine Skin Posts Record Sales for 2010: Up 55% Over 2009 2Divine Skin Posts Record Sales for 2010: Up 55% Over 2009 3