Navigation Links
Shifting the balance between good fat and bad fat
Date:1/4/2013

elieve that brown fat somehow malfunctions in obesity, but the details are unclear.

p62 shifts the balance between white fat and brown fat

In their latest study, Moscat and colleagues set out to pinpoint the specific tissue responsible for obesity when p62 is missing. They made several different mouse models, each missing p62 in just one specific organ system, such as the central nervous system, the liver, or muscle. In every case, the mice were normal. They weren't obese like the mice lacking p62 everywhere.

Then they made a mouse model lacking p62 only in their fat tissue. These mice were obese, just like the mice missing p62 in all tissues. Upon further study, the researchers found that p62 blocks the action of an enzyme called ERK while activating another enzyme called p38. When p62 is missing, the enzyme p38 is less active in brown fat, while ERK is more active in white fat. As a result, Moscat said, p62 is "a master regulator" in normal fat metabolism.

According to Moscat, the discovery of p62's role in brown fat tissue is encouraging, because fat tissue is much more accessible than other parts of the bodythe brain, for examplefor potential drug therapies. "This makes it easier to think about new strategies to control obesity," he said.

New methods for preventing or treating obesity, a major epidemic in the United States, are urgently needed. Drug therapies designed to minimize the intake of food have had limited success and also produce considerable side effects.


'/>"/>

Contact: Heather Buschman, Ph.D.
hbuschman@sanfordburnham.org
858-795-5343
Sanford-Burnham Medical Research Institute
Source:Eurekalert  

Page: 1 2

Related biology news :

1. New menhaden study will help identify balance between fishing and preserving Bay forage fish
2. Decoding the secrets of balance
3. Researchers find mechanism that gives plants balance
4. Increasing water scarcity in Californias Bay-Delta will necessitate trade-offs; hard decisions needed to balance various environmental risks
5. New study documents the natural relationship between CO2 concentrations and sea level
6. Ironing out the link between H. pylori infection and gastric cancer
7. The findings between DNMs and autism provides global view of mutability on human diseases
8. Dark Ages scourge enlightens modern struggle between man and microbes
9. Multiple sclerosis immune exchange between brain and blood is uncovered
10. Researchers study links between conflict and fisheries in East Africa
11. Mongolia and the Altai Mountains: Origins of genetic blending between Europeans and Asians
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Shifting the balance between good fat and bad fat
(Date:4/2/2015)... In the current eight ... the strongest competitors, showing outstanding performance in recognition ... is capable of a throughput of 5.000.000 fingerprints ... be ten times faster than most competitors and ...      (Photo: http://photos.prnewswire.com/prnh/20150402/738673-a ) , ...
(Date:4/1/2015)...  NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" or ... growing mobile commerce market, announces the second shipment of ... to early access pre-order customers. Feedback ... outlets including Walmart, Target, AT&T, Dunkin, Donuts, Stop & ... at all outlets and very easy to use. Several ...
(Date:3/30/2015)... , Mar. 26, 2015 Research and Markets ... the "Global Gesture Recognition Market in Automotive Sector ... analysts forecast the Global Gesture Recognition market in Automotive ... the period 2013-2018. Gesture recognition is the ... different gestures of an individual. Gesture recognition technology can ...
Breaking Biology News(10 mins):DERMALOG AFIS Emerges as Performance Winner in NIST Benchmark Test 2DERMALOG AFIS Emerges as Performance Winner in NIST Benchmark Test 3NXT-ID Reports Second Shipment of Wocket Smart Wallets Underway to Early Access Pre-order Customers and Provides User Feedback 2NXT-ID Reports Second Shipment of Wocket Smart Wallets Underway to Early Access Pre-order Customers and Provides User Feedback 3NXT-ID Reports Second Shipment of Wocket Smart Wallets Underway to Early Access Pre-order Customers and Provides User Feedback 4Global Gesture Recognition Market in Automotive Sector Report 2015 - Growing Number of Partnerships 2
... I'd like to see how they calculated that, and their standard ... yet! Still, if it's a real trend, it could be alarming. ... change its pH, I guess! , A report issued by ... world's oceans. "If CO2 from human activities continues to rise, the ...
... from a study on a promising new vaccine against ... cervical pre-cancers and non-invasive cervical cancer, according to a ... Research's 4th Annual Frontiers in Cancer Prevention Research meeting ... phase III study, originally published in early October, confirmed ...
... Science University researchers have identified some of the key ... by multiple sclerosis (MS), complications of premature birth, and ... about why the nervous system fails to repair itself ... brain damage could be reversed. The research is published ...
Cached Biology News:Oceans turning to acid from rise in CO2 2Updated data on novel HPV vaccine confirms efficacy in large population 2Molecular Partners Required For Appropriate Neuronal Gene Repression 2Molecular Partners Required For Appropriate Neuronal Gene Repression 3Molecular Partners Required For Appropriate Neuronal Gene Repression 4
(Date:4/16/2015)... Miami, FL (PRWEB) April 16, 2015 ... therapy cap distribution and physician network in Europe ... marketing company has appointed Fernando Bermúdez, former Business ... Director. , An industry veteran, Mr. Bermúdez’s professional ... by 75% in Spain, while also penetrating the ...
(Date:4/16/2015)... 16, 2015  Schulman Associates IRB, Inc., the industry-leading ... a long-term lease on Laboratory Drive in the heart ... . The location will house review board and service ... quality reviews and customer service to clients. ... Schulman in the deal, while Capital Associates Management, LLC ...
(Date:4/16/2015)... 2015 According to the 2014 ... outside source was ranked first among the leading ... to lifting, pushing, pulling, holding, carrying, or throwing ... The David Round Company takes statistics like this ... hard to develop and design equipment that prevents ...
(Date:4/16/2015)... April 16, 2015 The Council ... the prestigious 2015 Borlaug CAST Communication Award goes ... at Tuskegee University in Alabama. Award nominees must ... public presentations; and/or the use of television, radio, ... three areas. As a specialist in the field ...
Breaking Biology Technology:Capillus, LLC Extends Laser Hair Therapy Products to Europe and Asia 2Schulman IRB to Open Office in Research Triangle Park, N.C. 2The David Round Company Helps Companies Meet OSHA Standards by Combining Safety, Ergonomics, and Productivity 2The 2015 Borlaug CAST Communication Award Goes to Channapatna Prakash 2
... SyntheMed, Inc. (OTC,Bulletin Board: SYMD), a biomaterials ... drug delivery products and other,surgical implants, announced today ... 2008 MedTech conference being held in Washington, D.C. ... CEO of SyntheMed, is scheduled,to present on Wednesday, ...
... Keck Graduate Institute,(KGI) today announced that it will ... the latest developments in mammalian cell culture,from November ... explosive growth over the,last 25 years," said Matt ... and director of the Amgen Bioprocessing Center at ...
... results of implant operations., SAN CLEMENTE, Calif., ... to orthopedic surgeons being able to immediately gauge ... LifeModeler, Inc.,The company, a leading global provider of ... $400,000 of software and,services to InMotion Musculoskeletal Institute ...
Cached Biology Technology:SyntheMed To Present at the AdvaMed 2008 MedTech Conference 2KGI Offers Mammalian Cell Culture Program for Biotech Industry Professionals 2LifeModeler, Inc. Provides $400,000 Grant to InMotion Musculoskeletal Institute 2
Handles samples from from 75l to 150l...
PKA Sampler Kit 10 mu g each...
Chaperone Sampler Kit 10 mu g each...
... Solid phase reagent ... purification; Easy & unique ... Compatible with detergents and ... & recover non-envelop viruses ...
Biology Products: