Navigation Links
Shift work may be associated with decreased risk of skin cancer
Date:3/2/2011

Boston, MA - Melatonin is known to have cancer-protective properties, and shift work can induce desynchrony of the circadian system, reducing melatonin production. Shift work has been thought to have important health impacts, with evidence linking shift work to an increased risk of several cancers including breast, endometrial, prostate, and colorectal, and non-Hodgkin lymphoma. In a recent study, researchers at Brigham and Women's Hospital (BWH) found that shift work may be associated with a reduced risk of skin cancer in women. These findings are published online in the Journal of the National Cancer Institute.

"Shift work has been associated with increased risk of certain cancers and chronic non-malignant diseases such as gastrointestinal disorders, cardiovascular disease, and diabetes," said lead study author Eva Schernhammer, MD, DrPh, a researcher in the Channing Laboratory at BWH. "However, while shift work has been associated with other cancers, the risk of skin cancer among night-shift workers is unknown."

The researchers documented 10,799 incidents of skin cancer in 68,336 women in the Nurses' Health Study over 18 years of follow-up and examined the relationship between rotating night shifts and skin cancer. They found that higher duration of working rotating nightshifts was associated with a significantly lower risk of skin cancer.

When examining the effect of night shift work on different types of skin cancer, although the risk for each skin cancer (basal cell carcinoma, squamous cell carcinoma, and melanoma) decreased, the strongest association was observed for melanoma. Working ten or more years of rotating night-shifts was associated with 44 percent decreased risk of melanoma.

The researchers also found that darker-haired women in the study had the lowest risk of skin cancer. There were no differences in risk by sunlight exposure level at baseline, geographic residence or body location of skin cancer. That the inverse association was strongest among women with dark hair raises the possibility for several mechanistic explanations, including a genetic component that may affect both the extent of melatonin suppression during night work and skin cancer risk.

"Although higher melatonin levels appear to be beneficial in individuals with stable circadian rhythms, in shift workers, for certain disease outcomes melatonin suppression may actually be more beneficial," concluded Dr. Schernhammer.


'/>"/>

Contact: Holly Brown-Ayers
hbrown-ayers@partners.org
617-534-1603
Brigham and Women's Hospital
Source:Eurekalert

Related biology news :

1. New study illustrates shifting biomes in Alaska
2. Vet meds big shift to more women, fewer men driven by falling barriers, more female grads
3. Shifting forms: Penn study shows how variations of same protein affect immune response
4. Epidemic played large role in shift of attitudes on abortion, author says
5. Bald eagle diet shift enhances conservation
6. Model predicts shifts in carbon absorption by forest canopies
7. Shifting cellular energy metabolism may help treat cardiovascular disease
8. Shape shifters: Researchers create new breed of antennas
9. Bacterial ropes tie down shifting Southwest
10. North Atlantic fish populations shifting as ocean temperatures warm
11. Changes in brain chemicals mark shifts in infant learning
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/11/2017)... 11, 2017 Crossmatch®, a globally-recognized leader ... today announced that it has been awarded a ... Activity (IARPA) to develop next-generation Presentation Attack Detection ... "Innovation has been a driving force within Crossmatch ... allow us to innovate and develop new technologies ...
(Date:4/6/2017)... Forecasts by Product Type (EAC), ... End-Use (Transportation & Logistics, Government & Public Sector, Utilities ... Generation Facility, Nuclear Power), Industrial, Retail, Business Organisation (BFSI), ... you looking for a definitive report on the $27.9bn ... ...
(Date:4/4/2017)... --  EyeLock LLC , a leader of iris-based identity ... and Trademark Office (USPTO) has issued U.S. Patent No. ... iris image with a face image acquired in sequence ... th issued patent. "The issuance ... multi-modal biometric capabilities that have recently come to market ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... ... 12, 2017 , ... They call it the “hairy ball.” ... depiction of a system of linkages and connections so complex and dense that ... computer science at Worcester Polytechnic Institute (WPI) and director of the university’s bioinformatics ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... the pharmaceutical and biotechnology industries to improve patient outcomes and quality of life, ... in analytical testing are being attributed to new regulatory requirements for all new ...
(Date:10/11/2017)... ... October 11, 2017 , ... ComplianceOnline’s Medical Device Summit is ... and 8th June 2018 in San Francisco, CA. The Summit brings together current and ... distinguished CEOs, board directors and government officials from around the world to address key ...
(Date:10/11/2017)... ... October 11, 2017 , ... A new ... rates in frozen and fresh in vitro fertilization (IVF) transfer cycles. ... to IVF success. , After comparing the results from the fresh and frozen ...
Breaking Biology Technology: